FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387451054> ?p ?o ?g. }

• W4387451054 abstract "Bladder cancer is one of the most common type of cancers globally, and the majority of cases belong to urothelial bladder carcinoma (UBC) type. Current researches have demonstrated that multiple genomic abnormalities are related to the sensitivity of cisplatin-based chemotherapy in bladder cancer patients. Previous findings have indicated a controversial role of Ubiquitin Carboxy-Terminal Hydrolase L1 (UCHL1) in malignancy, so we aimed to further explore the role of UCHL1 in UBC.UBC cell lines and The Cancer Genome Atlas (TCGA) in-silico datasets were utilized to investigate UCHL1 expression pattern and functional as well as prognostic impacts in UBC cancer cell line models and patients. UCHL1 overexpression and silencing vectors and subsequent immunoprecipitation/ubiquitination experiments in combination of cellular functional assays were conducted to explore UCHL1-PKM2 interaction axis and its significance in UBC malignancy.UCHL1 was significantly up-regulated in UBC cancer cells and UCHL1 high-expression was associated with higher pathology/clinical grade and significantly inferior overall prognosis of UBC patients. UCHL1 interacted with PKM2 and enhanced PKM2 protein level through inhibition of PKM2 protein degradation via ubiquitination process. UCHL1-PKM2 interaction significantly promoted UBC cellular proliferation, metastasis and invasion activities.UCHL1-PKM2 interaction played an interesting role in UBC tumor cell proliferation, migration and metastasis. Our study suggests PKM2-targeted treatment might have a potential value in metastatic malignancy therapy development in the future." @default.
• W4387451054 created "2023-10-10" @default.
• W4387451054 creator A5006141701 @default.
• W4387451054 creator A5006554681 @default.
• W4387451054 creator A5017129280 @default.
• W4387451054 creator A5022659563 @default.
• W4387451054 creator A5073099885 @default.
• W4387451054 date "2023-10-09" @default.
• W4387451054 modified "2023-10-12" @default.
• W4387451054 title "UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells" @default.
• W4387451054 cites W1602635175 @default.
• W4387451054 cites W1840175275 @default.
• W4387451054 cites W1893588230 @default.
• W4387451054 cites W1966696908 @default.
• W4387451054 cites W1980667399 @default.
• W4387451054 cites W2000577272 @default.
• W4387451054 cites W2023006686 @default.
• W4387451054 cites W2029132015 @default.
• W4387451054 cites W2033775272 @default.
• W4387451054 cites W2047200931 @default.
• W4387451054 cites W2096600031 @default.
• W4387451054 cites W2130935241 @default.
• W4387451054 cites W2131178190 @default.
• W4387451054 cites W2132930322 @default.
• W4387451054 cites W2137616140 @default.
• W4387451054 cites W2151386220 @default.
• W4387451054 cites W2165256106 @default.
• W4387451054 cites W2168846224 @default.
• W4387451054 cites W2170705825 @default.
• W4387451054 cites W2308167615 @default.
• W4387451054 cites W2443056117 @default.
• W4387451054 cites W2473162054 @default.
• W4387451054 cites W2509266256 @default.
• W4387451054 cites W2527802349 @default.
• W4387451054 cites W2793985169 @default.
• W4387451054 cites W2806165616 @default.
• W4387451054 cites W2916183155 @default.
• W4387451054 cites W2919189760 @default.
• W4387451054 cites W3031776613 @default.
• W4387451054 cites W3109467285 @default.
• W4387451054 cites W3196745276 @default.
• W4387451054 cites W4211115520 @default.
• W4387451054 doi "https://doi.org/10.18632/aging.205097" @default.
• W4387451054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37815895" @default.
• W4387451054 hasPublicationYear "2023" @default.
• W4387451054 type Work @default.
• W4387451054 citedByCount "0" @default.
• W4387451054 crossrefType "journal-article" @default.
• W4387451054 hasAuthorship W4387451054A5006141701 @default.
• W4387451054 hasAuthorship W4387451054A5006554681 @default.
• W4387451054 hasAuthorship W4387451054A5017129280 @default.
• W4387451054 hasAuthorship W4387451054A5022659563 @default.
• W4387451054 hasAuthorship W4387451054A5073099885 @default.
• W4387451054 hasBestOaLocation W43874510541 @default.
• W4387451054 hasConcept C104317684 @default.
• W4387451054 hasConcept C10730799 @default.
• W4387451054 hasConcept C119056186 @default.
• W4387451054 hasConcept C121608353 @default.
• W4387451054 hasConcept C134018914 @default.
• W4387451054 hasConcept C20251656 @default.
• W4387451054 hasConcept C203014093 @default.
• W4387451054 hasConcept C204232928 @default.
• W4387451054 hasConcept C25602115 @default.
• W4387451054 hasConcept C2776694085 @default.
• W4387451054 hasConcept C2778239845 @default.
• W4387451054 hasConcept C2779013556 @default.
• W4387451054 hasConcept C2779399171 @default.
• W4387451054 hasConcept C2780352672 @default.
• W4387451054 hasConcept C2780854706 @default.
• W4387451054 hasConcept C502942594 @default.
• W4387451054 hasConcept C54355233 @default.
• W4387451054 hasConcept C62112901 @default.
• W4387451054 hasConcept C62231903 @default.
• W4387451054 hasConcept C86803240 @default.
• W4387451054 hasConcept C96232424 @default.
• W4387451054 hasConceptScore W4387451054C104317684 @default.
• W4387451054 hasConceptScore W4387451054C10730799 @default.
• W4387451054 hasConceptScore W4387451054C119056186 @default.
• W4387451054 hasConceptScore W4387451054C121608353 @default.
• W4387451054 hasConceptScore W4387451054C134018914 @default.
• W4387451054 hasConceptScore W4387451054C20251656 @default.
• W4387451054 hasConceptScore W4387451054C203014093 @default.
• W4387451054 hasConceptScore W4387451054C204232928 @default.
• W4387451054 hasConceptScore W4387451054C25602115 @default.
• W4387451054 hasConceptScore W4387451054C2776694085 @default.
• W4387451054 hasConceptScore W4387451054C2778239845 @default.
• W4387451054 hasConceptScore W4387451054C2779013556 @default.
• W4387451054 hasConceptScore W4387451054C2779399171 @default.
• W4387451054 hasConceptScore W4387451054C2780352672 @default.
• W4387451054 hasConceptScore W4387451054C2780854706 @default.
• W4387451054 hasConceptScore W4387451054C502942594 @default.
• W4387451054 hasConceptScore W4387451054C54355233 @default.
• W4387451054 hasConceptScore W4387451054C62112901 @default.
• W4387451054 hasConceptScore W4387451054C62231903 @default.
• W4387451054 hasConceptScore W4387451054C86803240 @default.
• W4387451054 hasConceptScore W4387451054C96232424 @default.
• W4387451054 hasLocation W43874510541 @default.
• W4387451054 hasLocation W43874510542 @default.
• W4387451054 hasOpenAccess W4387451054 @default.
• W4387451054 hasPrimaryLocation W43874510541 @default.

• next