FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387451333> ?p ?o ?g. }

• W4387451333 abstract "Abstract Protein structure prediction pipelines based on artificial intelligence, such as AlphaFold2, have achieved near-experimental accuracy. These advanced pipelines mainly rely on multiple sequence alignments (MSAs) as inputs to learn the co-evolution information from the homologous sequences. Nonetheless, searching MSAs from protein databases is time consuming, usually taking tens of minutes. Consequently, we attempt to explore the limits of fast protein structure prediction by using only primary structures of proteins. Our proposed method, HelixFold-Single, combines a large-scale protein language model with the superior geometric learning capability of AlphaFold2. HelixFold-Single first pre-trains a large-scale protein language model with thousands of millions of primary structures utilizing the self-supervised learning paradigm, which will be used as an alternative to MSAs for learning the co-evolution information. Then, by combining the pre-trained protein language model and the essential components of AlphaFold2, we obtain an end-to-end differentiable model to predict the three-dimensional coordinates of atoms from only the primary structure. HelixFold-Single is validated on datasets CASP14 and CAMEO, achieving competitive accuracy with the MSA-based methods on targets with large homologous families. Furthermore, HelixFold-Single consumes much less time than the mainstream pipelines for protein structure prediction, demonstrating its potential in tasks requiring many predictions." @default.
• W4387451333 created "2023-10-10" @default.
• W4387451333 creator A5015314503 @default.
• W4387451333 creator A5030589527 @default.
• W4387451333 creator A5035800786 @default.
• W4387451333 creator A5043114588 @default.
• W4387451333 creator A5047663685 @default.
• W4387451333 creator A5065859286 @default.
• W4387451333 creator A5065938126 @default.
• W4387451333 creator A5074137196 @default.
• W4387451333 creator A5076555816 @default.
• W4387451333 creator A5083268016 @default.
• W4387451333 creator A5086931226 @default.
• W4387451333 date "2023-10-09" @default.
• W4387451333 modified "2023-10-11" @default.
• W4387451333 title "A method for multiple-sequence-alignment-free protein structure prediction using a protein language model" @default.
• W4387451333 cites W1987134040 @default.
• W4387451333 cites W2073758233 @default.
• W4387451333 cites W2102461176 @default.
• W4387451333 cites W2130479394 @default.
• W4387451333 cites W2152811165 @default.
• W4387451333 cites W2161151688 @default.
• W4387451333 cites W2557595285 @default.
• W4387451333 cites W2970476646 @default.
• W4387451333 cites W2997234557 @default.
• W4387451333 cites W3104537585 @default.
• W4387451333 cites W3111174583 @default.
• W4387451333 cites W3133458480 @default.
• W4387451333 cites W3146944767 @default.
• W4387451333 cites W3171848268 @default.
• W4387451333 cites W3177828909 @default.
• W4387451333 cites W3186179742 @default.
• W4387451333 cites W3191761521 @default.
• W4387451333 cites W3193271391 @default.
• W4387451333 cites W3193589100 @default.
• W4387451333 cites W3198923619 @default.
• W4387451333 cites W3211795435 @default.
• W4387451333 cites W3212854871 @default.
• W4387451333 cites W4281291878 @default.
• W4387451333 cites W4287724045 @default.
• W4387451333 cites W4313430582 @default.
• W4387451333 doi "https://doi.org/10.1038/s42256-023-00721-6" @default.
• W4387451333 hasPublicationYear "2023" @default.
• W4387451333 type Work @default.
• W4387451333 citedByCount "0" @default.
• W4387451333 crossrefType "journal-article" @default.
• W4387451333 hasAuthorship W4387451333A5015314503 @default.
• W4387451333 hasAuthorship W4387451333A5030589527 @default.
• W4387451333 hasAuthorship W4387451333A5035800786 @default.
• W4387451333 hasAuthorship W4387451333A5043114588 @default.
• W4387451333 hasAuthorship W4387451333A5047663685 @default.
• W4387451333 hasAuthorship W4387451333A5065859286 @default.
• W4387451333 hasAuthorship W4387451333A5065938126 @default.
• W4387451333 hasAuthorship W4387451333A5074137196 @default.
• W4387451333 hasAuthorship W4387451333A5076555816 @default.
• W4387451333 hasAuthorship W4387451333A5083268016 @default.
• W4387451333 hasAuthorship W4387451333A5086931226 @default.
• W4387451333 hasBestOaLocation W43874513331 @default.
• W4387451333 hasConcept C10010492 @default.
• W4387451333 hasConcept C104317684 @default.
• W4387451333 hasConcept C119857082 @default.
• W4387451333 hasConcept C121332964 @default.
• W4387451333 hasConcept C124101348 @default.
• W4387451333 hasConcept C154945302 @default.
• W4387451333 hasConcept C167625842 @default.
• W4387451333 hasConcept C178180057 @default.
• W4387451333 hasConcept C18051474 @default.
• W4387451333 hasConcept C185592680 @default.
• W4387451333 hasConcept C200307862 @default.
• W4387451333 hasConcept C2778112365 @default.
• W4387451333 hasConcept C41008148 @default.
• W4387451333 hasConcept C46141821 @default.
• W4387451333 hasConcept C47701112 @default.
• W4387451333 hasConcept C54355233 @default.
• W4387451333 hasConcept C55493867 @default.
• W4387451333 hasConcept C66153294 @default.
• W4387451333 hasConcept C86803240 @default.
• W4387451333 hasConceptScore W4387451333C10010492 @default.
• W4387451333 hasConceptScore W4387451333C104317684 @default.
• W4387451333 hasConceptScore W4387451333C119857082 @default.
• W4387451333 hasConceptScore W4387451333C121332964 @default.
• W4387451333 hasConceptScore W4387451333C124101348 @default.
• W4387451333 hasConceptScore W4387451333C154945302 @default.
• W4387451333 hasConceptScore W4387451333C167625842 @default.
• W4387451333 hasConceptScore W4387451333C178180057 @default.
• W4387451333 hasConceptScore W4387451333C18051474 @default.
• W4387451333 hasConceptScore W4387451333C185592680 @default.
• W4387451333 hasConceptScore W4387451333C200307862 @default.
• W4387451333 hasConceptScore W4387451333C2778112365 @default.
• W4387451333 hasConceptScore W4387451333C41008148 @default.
• W4387451333 hasConceptScore W4387451333C46141821 @default.
• W4387451333 hasConceptScore W4387451333C47701112 @default.
• W4387451333 hasConceptScore W4387451333C54355233 @default.
• W4387451333 hasConceptScore W4387451333C55493867 @default.
• W4387451333 hasConceptScore W4387451333C66153294 @default.
• W4387451333 hasConceptScore W4387451333C86803240 @default.
• W4387451333 hasLocation W43874513331 @default.
• W4387451333 hasOpenAccess W4387451333 @default.
• W4387451333 hasPrimaryLocation W43874513331 @default.
• W4387451333 hasRelatedWork W1888349473 @default.

• next