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- W4387451683 abstract "<ns4:p>Tyrosine-protein kinase SYK, encoded by the <ns4:italic>SYK</ns4:italic> gene, is a non-receptor type protein kinase which mediates immune signal transduction through immunoreceptors. Tyrosine-protein kinase SYK expression has been associated with the development of various inflammatory diseases, cancer and neurodegenerative conditions. The reproducibility of tyrosine-protein kinase SYK research would help elucidate the mechanism in which it causes neuroinflammation as well as its potential as a novel target to treat Alzheimer’s disease. This would be facilitated with the availability of high-quality tyrosine-protein kinase SYK. In this study, we characterized thirteen tyrosine-protein kinase SYK commercial antibodies for Western Blot, immunoprecipitation, and immunofluorescence using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. We identified many high-performing antibodies and encourage readers to use this report as a guide to select the most appropriate antibody for their specific needs.</ns4:p>" @default.
- W4387451683 created "2023-10-10" @default.
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- W4387451683 date "2023-10-09" @default.
- W4387451683 modified "2023-10-11" @default.
- W4387451683 title "Identification of high-performing antibodies for tyrosine-protein kinase SYK for use in Western Blot, immunoprecipitation and immunofluorescence" @default.
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- W4387451683 doi "https://doi.org/10.12688/f1000research.140456.2" @default.
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