Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387451801> ?p ?o ?g. }
- W4387451801 abstract "Abstract Transition metal-catalyzed asymmetric hydrofunctionalizations of unsaturated bonds via π-ƞ 3 substitution have emerged as a reliable method to construct stereogenic centers, and mainly rely on the use of heteroatom-based or carbon nucleophiles bearing acidic C-H bonds. In comparison, sp 2 carbon nucleophiles are generally not under consideration because of enormous challenges in cleaving corresponding inert sp 2 C-H bonds. Here, we report a protocol to achieve asymmetric formal sp 2 hydrocarbonations, including hydroalkenylation, hydroallenylation and hydroketenimination of both 1,3-dienes and alkynes via hydroalkylation and Wittig reaction cascade. A series of unachievable motifs via hydrofunctionalizations, such as di-, tri- and tetra-substituted alkenes, di-, tri- and tetra-substituted allenes, and tri-substituted ketenimines in allyl skeletons are all facilely constructed in high regio-, diastereo- and enantioselectivities with this cascade design. Stereodivergent synthesis of all four stereoisomers of 1,4-diene bearing a stereocenter and Z/E-controllable olefin unit highlights the power of present protocol. An interesting mechanistic feature is revealed that alkyne actually undergoes hydrocarbonation via the formation of conjugated diene intermediate, different from conventional viewpoint that the hydrofunctionalization of alkynes only involves allene species." @default.
- W4387451801 created "2023-10-10" @default.
- W4387451801 creator A5042616865 @default.
- W4387451801 creator A5080760534 @default.
- W4387451801 creator A5089315730 @default.
- W4387451801 date "2023-10-09" @default.
- W4387451801 modified "2023-10-13" @default.
- W4387451801 title "Asymmetric formal sp2-hydrocarbonations of dienes and alkynes via palladium hydride catalysis" @default.
- W4387451801 cites W1974977083 @default.
- W4387451801 cites W1983310985 @default.
- W4387451801 cites W2016563542 @default.
- W4387451801 cites W2023284052 @default.
- W4387451801 cites W2037485180 @default.
- W4387451801 cites W2040718295 @default.
- W4387451801 cites W2075898338 @default.
- W4387451801 cites W2095949744 @default.
- W4387451801 cites W2113441566 @default.
- W4387451801 cites W2136117990 @default.
- W4387451801 cites W2140026331 @default.
- W4387451801 cites W2140889506 @default.
- W4387451801 cites W2147920142 @default.
- W4387451801 cites W2152045267 @default.
- W4387451801 cites W2183044313 @default.
- W4387451801 cites W2591523563 @default.
- W4387451801 cites W2608279822 @default.
- W4387451801 cites W2618734939 @default.
- W4387451801 cites W2749590733 @default.
- W4387451801 cites W2766334211 @default.
- W4387451801 cites W2768069613 @default.
- W4387451801 cites W2786142683 @default.
- W4387451801 cites W2800193746 @default.
- W4387451801 cites W2887684925 @default.
- W4387451801 cites W2887860290 @default.
- W4387451801 cites W2891855320 @default.
- W4387451801 cites W2900630252 @default.
- W4387451801 cites W2902030978 @default.
- W4387451801 cites W2909453122 @default.
- W4387451801 cites W2936579714 @default.
- W4387451801 cites W2938777031 @default.
- W4387451801 cites W2944619666 @default.
- W4387451801 cites W2950013459 @default.
- W4387451801 cites W2951837864 @default.
- W4387451801 cites W2954442735 @default.
- W4387451801 cites W2969753825 @default.
- W4387451801 cites W2969856757 @default.
- W4387451801 cites W2971586612 @default.
- W4387451801 cites W2994706619 @default.
- W4387451801 cites W2995419146 @default.
- W4387451801 cites W2998123831 @default.
- W4387451801 cites W3007497093 @default.
- W4387451801 cites W3008211915 @default.
- W4387451801 cites W3010488920 @default.
- W4387451801 cites W3021187151 @default.
- W4387451801 cites W3022526785 @default.
- W4387451801 cites W3037325006 @default.
- W4387451801 cites W3064275663 @default.
- W4387451801 cites W3082665242 @default.
- W4387451801 cites W3093693892 @default.
- W4387451801 cites W3108538217 @default.
- W4387451801 cites W3113622222 @default.
- W4387451801 cites W3157787208 @default.
- W4387451801 cites W3163473284 @default.
- W4387451801 cites W3165068819 @default.
- W4387451801 cites W3182596838 @default.
- W4387451801 cites W3191930344 @default.
- W4387451801 cites W3201288168 @default.
- W4387451801 cites W3203906605 @default.
- W4387451801 cites W3204787325 @default.
- W4387451801 cites W3215994886 @default.
- W4387451801 cites W4200362548 @default.
- W4387451801 cites W4221132196 @default.
- W4387451801 cites W4224304444 @default.
- W4387451801 cites W4280646488 @default.
- W4387451801 cites W4281385579 @default.
- W4387451801 cites W4282824329 @default.
- W4387451801 cites W4283071460 @default.
- W4387451801 cites W4284994439 @default.
- W4387451801 cites W4292111147 @default.
- W4387451801 cites W4308298779 @default.
- W4387451801 cites W4308953061 @default.
- W4387451801 cites W4311903919 @default.
- W4387451801 cites W4319879253 @default.
- W4387451801 cites W4319879296 @default.
- W4387451801 cites W4360603981 @default.
- W4387451801 cites W4360976271 @default.
- W4387451801 cites W4382631046 @default.
- W4387451801 cites W4386394114 @default.
- W4387451801 doi "https://doi.org/10.1038/s41467-023-42160-2" @default.
- W4387451801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37813855" @default.
- W4387451801 hasPublicationYear "2023" @default.
- W4387451801 type Work @default.
- W4387451801 citedByCount "0" @default.
- W4387451801 crossrefType "journal-article" @default.
- W4387451801 hasAuthorship W4387451801A5042616865 @default.
- W4387451801 hasAuthorship W4387451801A5080760534 @default.
- W4387451801 hasAuthorship W4387451801A5089315730 @default.
- W4387451801 hasBestOaLocation W43874518011 @default.
- W4387451801 hasConcept C134195300 @default.
- W4387451801 hasConcept C146686406 @default.
- W4387451801 hasConcept C155647269 @default.