FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387452488> ?p ?o ?g. }

• W4387452488 abstract "Rare cases of paraneoplastic obesity in children suggest sporadic obesity might also arise from an adaptive immune cell-mediated mechanism. Since the hypothalamus is a central regulator of feeding behavior and energy expenditure, we quantified lymphocytic inflammation in this region in a cohort of obese and non-obese human post-mortem brains. We report that CD8-positive cytotoxic T-cells are increased in hypothalamic median eminence/arcuate nucleus (ME/Arc) and bed nucleus of the stria terminalis in 40% of obese compared to non-obese patients, but not in other hypothalamic nuclei or brain regions. CD8 T-cells were most abundant in individuals with concurrent obesity and diabetes. Markers of cytotoxic T-cell induced damage, activated caspase 3 and poly-ADP ribose, were also elevated in the ME/Arc of obese patients. To provoke CD8 cytotoxic T-cell infiltrates in ventromedial region of hypothalamus in mice we performed stereotactic injections of an adeno-associated virus expressing immunogenic green fluorescent protein or saline. AAV but not saline injections triggered hypothalamic CD8 T-cell infiltrates associated with a rapid weight gain in mice recapitulating the findings in human obesity. This is the first description of the neuropathology of human obesity and when combined with its reconstitution in a mouse model suggests adaptive immunity may drive as much as 40% of the human condition." @default.
• W4387452488 created "2023-10-10" @default.
• W4387452488 creator A5024049848 @default.
• W4387452488 creator A5051406884 @default.
• W4387452488 creator A5085401344 @default.
• W4387452488 creator A5086124836 @default.
• W4387452488 creator A5091640490 @default.
• W4387452488 date "2023-10-09" @default.
• W4387452488 modified "2023-10-14" @default.
• W4387452488 title "CD8 cytotoxic T-cell infiltrates and cellular damage in the hypothalamus in human obesity" @default.
• W4387452488 cites W1964562779 @default.
• W4387452488 cites W1970331266 @default.
• W4387452488 cites W1976938970 @default.
• W4387452488 cites W1977709892 @default.
• W4387452488 cites W1986385745 @default.
• W4387452488 cites W2014778415 @default.
• W4387452488 cites W2017712441 @default.
• W4387452488 cites W2020793513 @default.
• W4387452488 cites W2042621509 @default.
• W4387452488 cites W2051215863 @default.
• W4387452488 cites W2062422180 @default.
• W4387452488 cites W2064431660 @default.
• W4387452488 cites W2067102521 @default.
• W4387452488 cites W2081413912 @default.
• W4387452488 cites W2093450168 @default.
• W4387452488 cites W2095446767 @default.
• W4387452488 cites W2128395587 @default.
• W4387452488 cites W2138468637 @default.
• W4387452488 cites W2154696002 @default.
• W4387452488 cites W2465638754 @default.
• W4387452488 cites W2575018533 @default.
• W4387452488 cites W2606592708 @default.
• W4387452488 cites W2620783811 @default.
• W4387452488 cites W2943632655 @default.
• W4387452488 cites W2949189204 @default.
• W4387452488 cites W4224310802 @default.
• W4387452488 cites W4282932431 @default.
• W4387452488 doi "https://doi.org/10.1186/s40478-023-01659-x" @default.
• W4387452488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37814324" @default.
• W4387452488 hasPublicationYear "2023" @default.
• W4387452488 type Work @default.
• W4387452488 citedByCount "0" @default.
• W4387452488 crossrefType "journal-article" @default.
• W4387452488 hasAuthorship W4387452488A5024049848 @default.
• W4387452488 hasAuthorship W4387452488A5051406884 @default.
• W4387452488 hasAuthorship W4387452488A5085401344 @default.
• W4387452488 hasAuthorship W4387452488A5086124836 @default.
• W4387452488 hasAuthorship W4387452488A5091640490 @default.
• W4387452488 hasBestOaLocation W43874524881 @default.
• W4387452488 hasConcept C126322002 @default.
• W4387452488 hasConcept C134018914 @default.
• W4387452488 hasConcept C154317977 @default.
• W4387452488 hasConcept C167672396 @default.
• W4387452488 hasConcept C171089720 @default.
• W4387452488 hasConcept C202751555 @default.
• W4387452488 hasConcept C203014093 @default.
• W4387452488 hasConcept C2776090121 @default.
• W4387452488 hasConcept C2777003273 @default.
• W4387452488 hasConcept C2778458369 @default.
• W4387452488 hasConcept C55493867 @default.
• W4387452488 hasConcept C71924100 @default.
• W4387452488 hasConcept C86803240 @default.
• W4387452488 hasConcept C8891405 @default.
• W4387452488 hasConceptScore W4387452488C126322002 @default.
• W4387452488 hasConceptScore W4387452488C134018914 @default.
• W4387452488 hasConceptScore W4387452488C154317977 @default.
• W4387452488 hasConceptScore W4387452488C167672396 @default.
• W4387452488 hasConceptScore W4387452488C171089720 @default.
• W4387452488 hasConceptScore W4387452488C202751555 @default.
• W4387452488 hasConceptScore W4387452488C203014093 @default.
• W4387452488 hasConceptScore W4387452488C2776090121 @default.
• W4387452488 hasConceptScore W4387452488C2777003273 @default.
• W4387452488 hasConceptScore W4387452488C2778458369 @default.
• W4387452488 hasConceptScore W4387452488C55493867 @default.
• W4387452488 hasConceptScore W4387452488C71924100 @default.
• W4387452488 hasConceptScore W4387452488C86803240 @default.
• W4387452488 hasConceptScore W4387452488C8891405 @default.
• W4387452488 hasFunder F4320309786 @default.
• W4387452488 hasFunder F4320315019 @default.
• W4387452488 hasFunder F4320318855 @default.
• W4387452488 hasFunder F4320332591 @default.
• W4387452488 hasFunder F4320337359 @default.
• W4387452488 hasFunder F4320337611 @default.
• W4387452488 hasIssue "1" @default.
• W4387452488 hasLocation W43874524881 @default.
• W4387452488 hasLocation W43874524882 @default.
• W4387452488 hasOpenAccess W4387452488 @default.
• W4387452488 hasPrimaryLocation W43874524881 @default.
• W4387452488 hasRelatedWork W2026447417 @default.
• W4387452488 hasRelatedWork W2061362010 @default.
• W4387452488 hasRelatedWork W2071958247 @default.
• W4387452488 hasRelatedWork W2123152448 @default.
• W4387452488 hasRelatedWork W2352277233 @default.
• W4387452488 hasRelatedWork W2394428521 @default.
• W4387452488 hasRelatedWork W2787943343 @default.
• W4387452488 hasRelatedWork W2898211049 @default.
• W4387452488 hasRelatedWork W3082261344 @default.
• W4387452488 hasRelatedWork W1974953353 @default.
• W4387452488 hasVolume "11" @default.
• W4387452488 isParatext "false" @default.

• next