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- W4387453934 abstract "Organismal health and survival depend on the ability to mount an effective immune response against infection. Yet, immune defence may be energy-demanding, resulting in fitness costs if investment in immune function deprives other physiological processes of resources. While evidence of costly immunity resulting in reduced longevity and reproduction is common, the role of energy-producing mitochondria on the magnitude of these costs is unknown. Here we employed Drosophila melanogaster cybrid lines, where several mitochondrial genotypes (mitotypes) were introgressed onto a single nuclear genetic background, to explicitly test the role of mitochondrial variation on the costs of immune stimulation. We exposed female flies carrying one of nine distinct mitotypes to either a benign, heat-killed bacterial pathogen (stimulating immune deployment while avoiding pathology), or to a sterile control. We measured lifespan, fecundity and locomotor activity. We observed mitotype-specific costs of immune stimulation and identified a positive genetic correlation between lifespan and the proportion of time cybrids spent moving while alive. Our results suggests that costs of immunity are highly variable depending on the mitochondrial genome, adding to a growing body of work highlighting the important role of mitochondrial variation in host-pathogen interactions." @default.
- W4387453934 created "2023-10-10" @default.
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- W4387453934 date "2023-10-06" @default.
- W4387453934 modified "2023-10-11" @default.
- W4387453934 title "Mitochondrial background can explain variable costs of immune deployment" @default.
- W4387453934 doi "https://doi.org/10.1101/2023.10.04.560830" @default.
- W4387453934 hasPublicationYear "2023" @default.
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