Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387454015> ?p ?o ?g. }
- W4387454015 abstract "Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) has posed a significant challenge to individuals’ health. Increasing evidence shows that patients with metabolic unhealthy obesity (MUO) and COVID-19 have severer complications and higher mortality rate. However, the molecular mechanisms underlying the association between MUO and COVID-19 are poorly understood. Methods: We sought to reveal the relationship between MUO and COVID-19 using bioinformatics and systems biology analysis approaches. Here, two datasets (GSE196822 and GSE152991) were employed to extract differentially expressed genes (DEGs) to identify common hub genes, shared pathways, transcriptional regulatory networks, gene-disease relationship and candidate drugs. Results: Based on the identified 65 common DEGs, the complement-related pathways and neutrophil degranulation-related functions are found to be mainly affected. The hub genes, which included SPI1, CD163, C1QB, SIGLEC1, C1QA, ITGAM, CD14, FCGR1A, VSIG4 and C1QC, were identified. From the interaction network analysis, 65 transcription factors (TFs) were found to be the regulatory signals. Some infections, inflammation and liver diseases were found to be most coordinated with the hub genes. Importantly, Paricalcitol, 3,3′,4,4′,5-Pentachlorobiphenyl, PD 98059, Medroxyprogesterone acetate, Dexamethasone and Tretinoin HL60 UP have shown possibility as therapeutic agents against COVID-19 and MUO. Conclusion: This study provides new clues and references to treat both COVID-19 and MUO." @default.
- W4387454015 created "2023-10-10" @default.
- W4387454015 creator A5014802304 @default.
- W4387454015 creator A5017396671 @default.
- W4387454015 creator A5028151790 @default.
- W4387454015 creator A5032724059 @default.
- W4387454015 creator A5042836530 @default.
- W4387454015 creator A5043061422 @default.
- W4387454015 creator A5045850914 @default.
- W4387454015 creator A5057275160 @default.
- W4387454015 creator A5065058975 @default.
- W4387454015 creator A5085869044 @default.
- W4387454015 date "2023-10-09" @default.
- W4387454015 modified "2023-10-11" @default.
- W4387454015 title "Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 on metabolic unhealthy obese patients" @default.
- W4387454015 cites W1969932671 @default.
- W4387454015 cites W1976937534 @default.
- W4387454015 cites W1985540837 @default.
- W4387454015 cites W1992214056 @default.
- W4387454015 cites W2062533676 @default.
- W4387454015 cites W2087460127 @default.
- W4387454015 cites W2103912979 @default.
- W4387454015 cites W2106509101 @default.
- W4387454015 cites W2142879323 @default.
- W4387454015 cites W2179438025 @default.
- W4387454015 cites W2215427915 @default.
- W4387454015 cites W2258433083 @default.
- W4387454015 cites W2314082472 @default.
- W4387454015 cites W2404800829 @default.
- W4387454015 cites W2806887367 @default.
- W4387454015 cites W2905589155 @default.
- W4387454015 cites W2921430101 @default.
- W4387454015 cites W3009799538 @default.
- W4387454015 cites W3009976289 @default.
- W4387454015 cites W3010441732 @default.
- W4387454015 cites W3045715678 @default.
- W4387454015 cites W3048869410 @default.
- W4387454015 cites W3087310313 @default.
- W4387454015 cites W3093404624 @default.
- W4387454015 cites W3096983947 @default.
- W4387454015 cites W3101109668 @default.
- W4387454015 cites W3106911080 @default.
- W4387454015 cites W3120675004 @default.
- W4387454015 cites W3120891398 @default.
- W4387454015 cites W3122663099 @default.
- W4387454015 cites W3133718453 @default.
- W4387454015 cites W3134682809 @default.
- W4387454015 cites W3152563552 @default.
- W4387454015 cites W3157056301 @default.
- W4387454015 cites W3166514766 @default.
- W4387454015 cites W3185056226 @default.
- W4387454015 cites W3189106061 @default.
- W4387454015 cites W3193211545 @default.
- W4387454015 cites W3202042764 @default.
- W4387454015 cites W3203430312 @default.
- W4387454015 cites W3204546097 @default.
- W4387454015 cites W3211430483 @default.
- W4387454015 cites W3211476931 @default.
- W4387454015 cites W3213276455 @default.
- W4387454015 cites W3214108503 @default.
- W4387454015 cites W4210642183 @default.
- W4387454015 cites W4210745336 @default.
- W4387454015 cites W4220784902 @default.
- W4387454015 cites W4220939068 @default.
- W4387454015 cites W4225513536 @default.
- W4387454015 cites W4229378155 @default.
- W4387454015 cites W4285086881 @default.
- W4387454015 cites W4291656940 @default.
- W4387454015 cites W4292180537 @default.
- W4387454015 cites W4292553100 @default.
- W4387454015 cites W4292939247 @default.
- W4387454015 cites W4293767725 @default.
- W4387454015 cites W4298140211 @default.
- W4387454015 cites W4307658748 @default.
- W4387454015 cites W4310490310 @default.
- W4387454015 cites W4311285716 @default.
- W4387454015 cites W4313880450 @default.
- W4387454015 cites W4380882628 @default.
- W4387454015 cites W4382753360 @default.
- W4387454015 doi "https://doi.org/10.3389/fmolb.2023.1274463" @default.
- W4387454015 hasPublicationYear "2023" @default.
- W4387454015 type Work @default.
- W4387454015 citedByCount "0" @default.
- W4387454015 crossrefType "journal-article" @default.
- W4387454015 hasAuthorship W4387454015A5014802304 @default.
- W4387454015 hasAuthorship W4387454015A5017396671 @default.
- W4387454015 hasAuthorship W4387454015A5028151790 @default.
- W4387454015 hasAuthorship W4387454015A5032724059 @default.
- W4387454015 hasAuthorship W4387454015A5042836530 @default.
- W4387454015 hasAuthorship W4387454015A5043061422 @default.
- W4387454015 hasAuthorship W4387454015A5045850914 @default.
- W4387454015 hasAuthorship W4387454015A5057275160 @default.
- W4387454015 hasAuthorship W4387454015A5065058975 @default.
- W4387454015 hasAuthorship W4387454015A5085869044 @default.
- W4387454015 hasBestOaLocation W43874540151 @default.
- W4387454015 hasConcept C104317684 @default.
- W4387454015 hasConcept C126322002 @default.
- W4387454015 hasConcept C134018914 @default.
- W4387454015 hasConcept C150194340 @default.
- W4387454015 hasConcept C162317418 @default.