Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387454146> ?p ?o ?g. }
- W4387454146 endingPage "2724" @default.
- W4387454146 startingPage "2724" @default.
- W4387454146 abstract "(1) Background Oral squamous cell carcinomas (OSCC) are a common malignancy of the oral cavity and are often diagnosed when they have already spread to the regional lymph nodes. Advanced stages of cancer are characterized by the development of distant metastases. Angiogenesis, a hallmark of cancer, is known to contribute to cancer progression and metastasis. High microvessel density (MVD) has been linked to poor clinical outcomes in various types of cancer. (2) Methods: In this study, we aimed to investigate the spatial heterogeneity of blood vessels by comparing the tumor center and invasion front and to evaluate its prognostic value in OSCC. A total of 71 OSCC patient specimens were collected. The tissue was immunohistochemically stained using CD31 antibody to assess the MVD in the tumor center and the invasion front. Furthermore, the associations between the histopathological parameters, including MVD, disease-free survival (DFS), and overall survival (OS) were computed. (3) Results: In our study, we found a significantly higher presence of blood vessels at the invasion front of OSCCs compared to the tumor center. However, we did not observe any significant differences in MVD between different tumor stages. High intratumoral MVD was shown to be a positive prognostic factor for DFS (p = 0.047). (4) Conclusions: To the best of our knowledge, we were the first to analyze MVD as a prognostic factor by considering its spatial heterogeneity in OSCC. However, further studies are warranted to further elucidate the complexity of microvascular spatial heterogeneity and its influence on prognosis." @default.
- W4387454146 created "2023-10-10" @default.
- W4387454146 creator A5011774727 @default.
- W4387454146 creator A5019227870 @default.
- W4387454146 creator A5027800346 @default.
- W4387454146 creator A5033363764 @default.
- W4387454146 creator A5033513615 @default.
- W4387454146 creator A5048194825 @default.
- W4387454146 creator A5048477745 @default.
- W4387454146 creator A5052570455 @default.
- W4387454146 creator A5070911062 @default.
- W4387454146 date "2023-10-08" @default.
- W4387454146 modified "2023-10-11" @default.
- W4387454146 title "Immunohistochemical Assessment of Microvessel Density in OSCC: Spatial Heterogeneity of Angiogenesis and Its Impact on Survival" @default.
- W4387454146 cites W1495287184 @default.
- W4387454146 cites W1939738412 @default.
- W4387454146 cites W1986969648 @default.
- W4387454146 cites W1995499810 @default.
- W4387454146 cites W2004769542 @default.
- W4387454146 cites W2010300658 @default.
- W4387454146 cites W2022540958 @default.
- W4387454146 cites W2024489667 @default.
- W4387454146 cites W2029190929 @default.
- W4387454146 cites W2037761545 @default.
- W4387454146 cites W2051526950 @default.
- W4387454146 cites W2067527269 @default.
- W4387454146 cites W2093916414 @default.
- W4387454146 cites W2103563357 @default.
- W4387454146 cites W2128490578 @default.
- W4387454146 cites W2129941826 @default.
- W4387454146 cites W2137293456 @default.
- W4387454146 cites W2148184207 @default.
- W4387454146 cites W2157769714 @default.
- W4387454146 cites W2158743409 @default.
- W4387454146 cites W2161579181 @default.
- W4387454146 cites W2319962899 @default.
- W4387454146 cites W2594211076 @default.
- W4387454146 cites W2801309958 @default.
- W4387454146 cites W2810645630 @default.
- W4387454146 cites W2906004830 @default.
- W4387454146 cites W2914098003 @default.
- W4387454146 cites W2918290632 @default.
- W4387454146 cites W2928092840 @default.
- W4387454146 cites W3015628445 @default.
- W4387454146 cites W3022902771 @default.
- W4387454146 cites W3036371598 @default.
- W4387454146 cites W3088894284 @default.
- W4387454146 cites W3089835536 @default.
- W4387454146 cites W3128646645 @default.
- W4387454146 cites W3142622887 @default.
- W4387454146 cites W3165968006 @default.
- W4387454146 cites W3173767537 @default.
- W4387454146 cites W3184831893 @default.
- W4387454146 cites W3216344381 @default.
- W4387454146 cites W4221085385 @default.
- W4387454146 cites W4225529913 @default.
- W4387454146 cites W4239909670 @default.
- W4387454146 cites W4321459492 @default.
- W4387454146 cites W4366828972 @default.
- W4387454146 doi "https://doi.org/10.3390/biomedicines11102724" @default.
- W4387454146 hasPublicationYear "2023" @default.
- W4387454146 type Work @default.
- W4387454146 citedByCount "0" @default.
- W4387454146 crossrefType "journal-article" @default.
- W4387454146 hasAuthorship W4387454146A5011774727 @default.
- W4387454146 hasAuthorship W4387454146A5019227870 @default.
- W4387454146 hasAuthorship W4387454146A5027800346 @default.
- W4387454146 hasAuthorship W4387454146A5033363764 @default.
- W4387454146 hasAuthorship W4387454146A5033513615 @default.
- W4387454146 hasAuthorship W4387454146A5048194825 @default.
- W4387454146 hasAuthorship W4387454146A5048477745 @default.
- W4387454146 hasAuthorship W4387454146A5052570455 @default.
- W4387454146 hasAuthorship W4387454146A5070911062 @default.
- W4387454146 hasBestOaLocation W43874541461 @default.
- W4387454146 hasConcept C121608353 @default.
- W4387454146 hasConcept C126322002 @default.
- W4387454146 hasConcept C142724271 @default.
- W4387454146 hasConcept C143998085 @default.
- W4387454146 hasConcept C204232928 @default.
- W4387454146 hasConcept C2776436680 @default.
- W4387454146 hasConcept C2778271429 @default.
- W4387454146 hasConcept C2778939058 @default.
- W4387454146 hasConcept C2779013556 @default.
- W4387454146 hasConcept C2779399171 @default.
- W4387454146 hasConcept C2780394083 @default.
- W4387454146 hasConcept C71924100 @default.
- W4387454146 hasConceptScore W4387454146C121608353 @default.
- W4387454146 hasConceptScore W4387454146C126322002 @default.
- W4387454146 hasConceptScore W4387454146C142724271 @default.
- W4387454146 hasConceptScore W4387454146C143998085 @default.
- W4387454146 hasConceptScore W4387454146C204232928 @default.
- W4387454146 hasConceptScore W4387454146C2776436680 @default.
- W4387454146 hasConceptScore W4387454146C2778271429 @default.
- W4387454146 hasConceptScore W4387454146C2778939058 @default.
- W4387454146 hasConceptScore W4387454146C2779013556 @default.
- W4387454146 hasConceptScore W4387454146C2779399171 @default.
- W4387454146 hasConceptScore W4387454146C2780394083 @default.
- W4387454146 hasConceptScore W4387454146C71924100 @default.