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• W4387454889 abstract "During the COVID-19 pandemic, several strategies were suggested for the management of the disease, including pharmacological and non-pharmacological treatments such as convalescent plasma (CP). The use of CP was suggested due to the beneficial results shown in treating other viral diseases. To determine the efficacy and safety of CP obtained from whole blood in patients with COVID-19. Pilot clinical trial in patients with COVID-19 from a general hospital. The subjects were separated into three groups that received the transfusion of 400 ml of CP (n = 23) or 400 ml of standard plasma (SP) (n = 19) and a non-transfused group (NT) (n = 37). Patients also received the standard available medical treatment for COVID 19. Subjects were followed up daily from admission to day 21. CP did not improve the survival curve in moderate and severe variants of COVID-19, nor did it reduce the degree of severity of the disease evaluated with the COVID-19 WHO and SOFA clinical progression scale. No patient had a severe post-transfusion reaction to CP. Treatment with CP does not reduce the mortality of patients even when its administration has a high degree of safety. Durante la pandemia de COVID-19 surgieron diversas estrategias para el manejo de la enfermedad, incluidos los tratamientos farmacológicos y no farmacológicos como el plasma convaleciente (PC). El uso de PC se sugirió debido a los resultados benéficos mostrados al tratar otras enfermedades virales. Determinar la eficacia y seguridad de la administración de PC obtenido de sangre total en pacientes con COVID-19. Ensayo clínico piloto en pacientes con COVID-19 de un hospital general. Los sujetos se separaron en tres grupos que recibieron la transfusión de 400 ml de PC (n = 23) o 400 ml de plasma estándar (PE) (n = 19) y un grupo no transfundido (NT) (n = 37). Los pacientes recibieron además el tratamiento médico estándar disponible para COVID 19. El seguimiento de los sujetos se llevó a cabo diariamente desde el ingreso hasta el día 21. El PC no mejoró la curva de supervivencia en las variantes moderadas y graves de COVID-19, ni disminuyó el grado de severidad de la enfermedad evaluado con la escala de progresión clínica COVID-19 OMS y SOFA. Ningún paciente presentó una reacción postransfusional severa al PC. El tratamiento con PC no disminuye la mortalidad de los pacientes, aun cuando su administración tiene un alto grado de seguridad." @default.
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• W4387454889 date "2023-10-01" @default.
• W4387454889 modified "2023-10-17" @default.
• W4387454889 title "Efficacy and safety of convalescent plasma administration in patients with COVID-19" @default.
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• W4387454889 doi "https://doi.org/10.1016/j.medcle.2023.05.019" @default.
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