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- W4387457682 abstract "Head and neck squamous cell carcinoma (HNSCC), as a complex and variable malignancy, poses a significant threat to human health. Since the intricate association between HPV and HNSCC emerged, its role within the TME has garnered extensive attention. HPV+HNSCC exhibits distinct immunological characteristics within the TME, intricately intertwined with mechanisms of immune evasion. HPV employs multifaceted pathways to intervene in metabolic regulation within the TME, exerting influence over immune cell functionality and neoplastic cell genesis. Furthermore, the heightened immune reactivity exhibited by HPV+HNSCC within the TME augments responses to immune interventions such as immune checkpoint inhibitors. Therefore, amidst the current limitations of therapeutic approaches, immunotherapy stands as a promising strategy to overcome the conventional confines of treating HNSCC. This article comprehensively outlines the impact of HPV on the inception and progression of HNSCC while discussing the amalgamation of metabolic regulation within the TME and immunotherapeutic strategies. By intervening in the reciprocal interactions between HPV and HNSCC within the TME, the potential to modulate the efficacy of immune-based treatments becomes evident. Concurrently, a synthesis of pertinent biomarker development is summarized. Such endeavors hold paramount significance for personalized therapeutic approaches and the more effective management of HNSCC patients." @default.
- W4387457682 created "2023-10-10" @default.
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- W4387457682 date "2023-10-09" @default.
- W4387457682 modified "2023-10-11" @default.
- W4387457682 title "Deciphering the role of HPV-mediated metabolic regulation in shaping the tumor microenvironment and its implications for immunotherapy in HNSCC" @default.
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- W4387457682 cites W1981989535 @default.
- W4387457682 cites W1986241711 @default.
- W4387457682 cites W1995508663 @default.
- W4387457682 cites W1996153254 @default.
- W4387457682 cites W1996216604 @default.
- W4387457682 cites W1998238876 @default.
- W4387457682 cites W2001961423 @default.
- W4387457682 cites W2015657357 @default.
- W4387457682 cites W2019608329 @default.
- W4387457682 cites W2025911843 @default.
- W4387457682 cites W2027538916 @default.
- W4387457682 cites W2041120394 @default.
- W4387457682 cites W2045059362 @default.
- W4387457682 cites W2053019589 @default.
- W4387457682 cites W2060786724 @default.
- W4387457682 cites W2061572018 @default.
- W4387457682 cites W2063348662 @default.
- W4387457682 cites W2067414861 @default.
- W4387457682 cites W2076951669 @default.
- W4387457682 cites W2081501450 @default.
- W4387457682 cites W2095844662 @default.
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- W4387457682 cites W2167742574 @default.
- W4387457682 cites W2170939558 @default.
- W4387457682 cites W2278282834 @default.
- W4387457682 cites W2292031635 @default.
- W4387457682 cites W2329517420 @default.
- W4387457682 cites W2528165959 @default.
- W4387457682 cites W2529484692 @default.
- W4387457682 cites W2730541855 @default.
- W4387457682 cites W2755864984 @default.
- W4387457682 cites W2773672680 @default.
- W4387457682 cites W2780574365 @default.
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- W4387457682 cites W2991497652 @default.
- W4387457682 cites W3001510615 @default.
- W4387457682 cites W3018127538 @default.
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- W4387457682 cites W3046740893 @default.
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- W4387457682 cites W3172952169 @default.
- W4387457682 cites W3213527410 @default.
- W4387457682 cites W3217171965 @default.
- W4387457682 cites W4214568242 @default.
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- W4387457682 doi "https://doi.org/10.3389/fimmu.2023.1275270" @default.
- W4387457682 hasPublicationYear "2023" @default.
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