FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387457907> ?p ?o ?g. }

• W4387457907 abstract "The study aims to monitor dihydroartemisinin-piperaquine (DHA-PPQ) efficacy in Plasmodium falciparum and detect molecular markers associated with its resistance.The world health organization standard protocol of the therapeutic efficacy study (TES) were performed in 2014-2018 and the integrated drug efficacy surveillance (iDES) in 2019-July 2023. Molecular markers were detected by polymerase chain reaction. The association between gene mutations and delayed parasite clearance were analyzed by the multivariate logistic regression analysis.A total of 226 P. falciparum patients were enrolled in the TES in 2014-2018, and 26 P. falciparum patients imported from Africa were recruited in the iDES in 2019-July 2023. The PCR-adjusted clinical and parasitological cure rate was 93.7% (95%CI: 92.6-99.5%) in the TES and 96.2% (95%CI: 80.4-99.9%) in the iDEs. Twelve mutants and an overall 55.0% prevalence of pfK13 mutations were detected. Of them, G533S, C447R, C447S, N458Y, C469Y and A676D were first detected out along the China-Myanmar border. Referred to the wild strain, adjusted odds ratios of treatment failure for G533S, N458Y and P574L by 42 days were 7.54(95% confidence interval [CI]: 1.605- 45.86), 13.68 (95%CI: 1.95- 130.72) and 89.00 (95%CI: 1.98- 2482.1), respectively.The efficacy of DHA-PPQ in 2014-2018 has declined compared to Year 2003-2013, but it is still effective for treatment of P. falciparum malaria. Results of the iDES indicate a risk of artemisinin resistance in Africa. The G533S, N458Y and P574L are associated with delayed parasite clearance and treatment failure." @default.
• W4387457907 created "2023-10-10" @default.
• W4387457907 creator A5009884211 @default.
• W4387457907 creator A5034108806 @default.
• W4387457907 creator A5054587971 @default.
• W4387457907 creator A5062073359 @default.
• W4387457907 creator A5064198654 @default.
• W4387457907 creator A5076940548 @default.
• W4387457907 creator A5089716001 @default.
• W4387457907 date "2023-10-01" @default.
• W4387457907 modified "2023-10-12" @default.
• W4387457907 title "Dihydroartemisinin-piperaquine efficacy in Plasmodium falciparum treatment and prevalence of drug-resistant molecular markers along China-Myanmar border in 2014-2023" @default.
• W4387457907 cites W1729017034 @default.
• W4387457907 cites W1893108453 @default.
• W4387457907 cites W1997241625 @default.
• W4387457907 cites W1999520705 @default.
• W4387457907 cites W2020171806 @default.
• W4387457907 cites W2032787443 @default.
• W4387457907 cites W2040095486 @default.
• W4387457907 cites W2042016552 @default.
• W4387457907 cites W2094356691 @default.
• W4387457907 cites W2156601125 @default.
• W4387457907 cites W2171102256 @default.
• W4387457907 cites W2171450360 @default.
• W4387457907 cites W2171526995 @default.
• W4387457907 cites W2337341485 @default.
• W4387457907 cites W2491414406 @default.
• W4387457907 cites W2491508274 @default.
• W4387457907 cites W2547295550 @default.
• W4387457907 cites W2595300397 @default.
• W4387457907 cites W2735848561 @default.
• W4387457907 cites W2802030719 @default.
• W4387457907 cites W2912798358 @default.
• W4387457907 cites W3129144768 @default.
• W4387457907 cites W3138899034 @default.
• W4387457907 cites W3200040377 @default.
• W4387457907 cites W3205406306 @default.
• W4387457907 cites W3207298171 @default.
• W4387457907 cites W4220819795 @default.
• W4387457907 cites W4229441993 @default.
• W4387457907 cites W4303927962 @default.
• W4387457907 cites W4311651370 @default.
• W4387457907 doi "https://doi.org/10.1016/j.jgar.2023.10.001" @default.
• W4387457907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37816434" @default.
• W4387457907 hasPublicationYear "2023" @default.
• W4387457907 type Work @default.
• W4387457907 citedByCount "0" @default.
• W4387457907 crossrefType "journal-article" @default.
• W4387457907 hasAuthorship W4387457907A5009884211 @default.
• W4387457907 hasAuthorship W4387457907A5034108806 @default.
• W4387457907 hasAuthorship W4387457907A5054587971 @default.
• W4387457907 hasAuthorship W4387457907A5062073359 @default.
• W4387457907 hasAuthorship W4387457907A5064198654 @default.
• W4387457907 hasAuthorship W4387457907A5076940548 @default.
• W4387457907 hasAuthorship W4387457907A5089716001 @default.
• W4387457907 hasBestOaLocation W43874579071 @default.
• W4387457907 hasConcept C114851261 @default.
• W4387457907 hasConcept C126322002 @default.
• W4387457907 hasConcept C156957248 @default.
• W4387457907 hasConcept C203014093 @default.
• W4387457907 hasConcept C2776120307 @default.
• W4387457907 hasConcept C2777616469 @default.
• W4387457907 hasConcept C2778048844 @default.
• W4387457907 hasConcept C2778371730 @default.
• W4387457907 hasConcept C2781160685 @default.
• W4387457907 hasConcept C44249647 @default.
• W4387457907 hasConcept C71924100 @default.
• W4387457907 hasConcept C86803240 @default.
• W4387457907 hasConcept C89423630 @default.
• W4387457907 hasConcept C90924648 @default.
• W4387457907 hasConceptScore W4387457907C114851261 @default.
• W4387457907 hasConceptScore W4387457907C126322002 @default.
• W4387457907 hasConceptScore W4387457907C156957248 @default.
• W4387457907 hasConceptScore W4387457907C203014093 @default.
• W4387457907 hasConceptScore W4387457907C2776120307 @default.
• W4387457907 hasConceptScore W4387457907C2777616469 @default.
• W4387457907 hasConceptScore W4387457907C2778048844 @default.
• W4387457907 hasConceptScore W4387457907C2778371730 @default.
• W4387457907 hasConceptScore W4387457907C2781160685 @default.
• W4387457907 hasConceptScore W4387457907C44249647 @default.
• W4387457907 hasConceptScore W4387457907C71924100 @default.
• W4387457907 hasConceptScore W4387457907C86803240 @default.
• W4387457907 hasConceptScore W4387457907C89423630 @default.
• W4387457907 hasConceptScore W4387457907C90924648 @default.
• W4387457907 hasLocation W43874579071 @default.
• W4387457907 hasLocation W43874579072 @default.
• W4387457907 hasOpenAccess W4387457907 @default.
• W4387457907 hasPrimaryLocation W43874579071 @default.
• W4387457907 hasRelatedWork W1993801326 @default.
• W4387457907 hasRelatedWork W2046323432 @default.
• W4387457907 hasRelatedWork W2069374568 @default.
• W4387457907 hasRelatedWork W2111813303 @default.
• W4387457907 hasRelatedWork W2148437908 @default.
• W4387457907 hasRelatedWork W2268089110 @default.
• W4387457907 hasRelatedWork W2356130562 @default.
• W4387457907 hasRelatedWork W2394331403 @default.
• W4387457907 hasRelatedWork W4302552177 @default.
• W4387457907 hasRelatedWork W4322629085 @default.
• W4387457907 isParatext "false" @default.
• W4387457907 isRetracted "false" @default.

• next