FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387458558> ?p ?o ?g. }

• W4387458558 endingPage "107393" @default.
• W4387458558 startingPage "107393" @default.
• W4387458558 abstract "BackgroundNRAS mutations are observed in less than 1% of non-small cell lung cancer (NSCLC). Clinical data regarding this rare subset of lung cancer are scarce and response to systemic treatment such as chemotherapy or immune checkpoint inhibitors (ICI) has never been reported.MethodsAll consecutive patients with an NRAS mutated NSCLC, diagnosed between August 2014 and November 2020 in 14 French centers, were included. Clinical and molecular data were collected and reviewed from medical records.ResultsOut of the 164 included patients, 106 (64.6%) were men, 150 (91.5%) were current or former smokers, and 104 (63.4%) had stage IV NSCLC at diagnosis. The median age was 62 years, and the most frequent histology was adenocarcinoma (81.7%). NRAS activating mutations were mostly found in codon 61 (70%), while codon 12 and 13 alterations were observed in 16.5% and 4.9% of patients, respectively. Programmed death ligand-1 expression level <1%/1–49%/≥50% were respectively found in 30.8%/27.1%/42.1% of tumors. With a median follow-up of 12.5 months, median overall survival (OS) of stage IV patients was 15.3 months (95% CI 9.9 – 27.6). No significant difference in OS was found according to the type of mutation (codon 61 vs. other), HR = 1.12 (95% CI 0.65 – 1.95). Among stage IV patients treated with platinum-based doublet (n = 66), ICI (n = 48), or combination of both (n = 10), objective response rate, and median progression free survival were respectively 45% and 5.8 months, 35% and 6.9 months, 70% and 8.6 months.ConclusionNRAS mutated NSCLC are characterized by a high frequency of smoking history and codon 61 mutations. Further studies are needed to confirm the encouraging outcome of immunotherapy in combination with chemotherapy." @default.
• W4387458558 created "2023-10-10" @default.
• W4387458558 creator A5002411531 @default.
• W4387458558 creator A5009821115 @default.
• W4387458558 creator A5011567129 @default.
• W4387458558 creator A5015766588 @default.
• W4387458558 creator A5021149995 @default.
• W4387458558 creator A5027068255 @default.
• W4387458558 creator A5030455508 @default.
• W4387458558 creator A5032393857 @default.
• W4387458558 creator A5036298255 @default.
• W4387458558 creator A5039964156 @default.
• W4387458558 creator A5045555988 @default.
• W4387458558 creator A5047814251 @default.
• W4387458558 creator A5053712155 @default.
• W4387458558 creator A5055246540 @default.
• W4387458558 creator A5063103135 @default.
• W4387458558 creator A5071449669 @default.
• W4387458558 creator A5073118412 @default.
• W4387458558 creator A5079524593 @default.
• W4387458558 creator A5090329560 @default.
• W4387458558 date "2023-10-01" @default.
• W4387458558 modified "2023-10-11" @default.
• W4387458558 title "Characterization of 164 patients with NRAS mutated non-small cell lung cancer (NSCLC)" @default.
• W4387458558 cites W1520577253 @default.
• W4387458558 cites W1532638044 @default.
• W4387458558 cites W1980209454 @default.
• W4387458558 cites W2028950794 @default.
• W4387458558 cites W2050211354 @default.
• W4387458558 cites W2057698420 @default.
• W4387458558 cites W2088293068 @default.
• W4387458558 cites W2096540669 @default.
• W4387458558 cites W2104347254 @default.
• W4387458558 cites W2113687561 @default.
• W4387458558 cites W2132630169 @default.
• W4387458558 cites W2137297899 @default.
• W4387458558 cites W2145411470 @default.
• W4387458558 cites W2158797210 @default.
• W4387458558 cites W2163798887 @default.
• W4387458558 cites W2173344695 @default.
• W4387458558 cites W2180481128 @default.
• W4387458558 cites W2246525736 @default.
• W4387458558 cites W2327437619 @default.
• W4387458558 cites W2561459036 @default.
• W4387458558 cites W2594529508 @default.
• W4387458558 cites W2767162493 @default.
• W4387458558 cites W2784371446 @default.
• W4387458558 cites W2796582438 @default.
• W4387458558 cites W2801625460 @default.
• W4387458558 cites W2890894948 @default.
• W4387458558 cites W2911842472 @default.
• W4387458558 cites W2922104964 @default.
• W4387458558 cites W2946166987 @default.
• W4387458558 cites W2949244813 @default.
• W4387458558 cites W2971257521 @default.
• W4387458558 cites W3005186000 @default.
• W4387458558 cites W3013377779 @default.
• W4387458558 cites W3034504519 @default.
• W4387458558 cites W3110814768 @default.
• W4387458558 cites W3127560436 @default.
• W4387458558 cites W3142010099 @default.
• W4387458558 cites W3152878368 @default.
• W4387458558 cites W3158697155 @default.
• W4387458558 cites W3183409909 @default.
• W4387458558 cites W3183860080 @default.
• W4387458558 cites W3212888956 @default.
• W4387458558 cites W4214564403 @default.
• W4387458558 cites W4214569871 @default.
• W4387458558 cites W4220801140 @default.
• W4387458558 cites W4224252326 @default.
• W4387458558 cites W4224273346 @default.
• W4387458558 cites W4226075561 @default.
• W4387458558 cites W4280522194 @default.
• W4387458558 cites W4384455562 @default.
• W4387458558 doi "https://doi.org/10.1016/j.lungcan.2023.107393" @default.
• W4387458558 hasPublicationYear "2023" @default.
• W4387458558 type Work @default.
• W4387458558 citedByCount "0" @default.
• W4387458558 crossrefType "journal-article" @default.
• W4387458558 hasAuthorship W4387458558A5002411531 @default.
• W4387458558 hasAuthorship W4387458558A5009821115 @default.
• W4387458558 hasAuthorship W4387458558A5011567129 @default.
• W4387458558 hasAuthorship W4387458558A5015766588 @default.
• W4387458558 hasAuthorship W4387458558A5021149995 @default.
• W4387458558 hasAuthorship W4387458558A5027068255 @default.
• W4387458558 hasAuthorship W4387458558A5030455508 @default.
• W4387458558 hasAuthorship W4387458558A5032393857 @default.
• W4387458558 hasAuthorship W4387458558A5036298255 @default.
• W4387458558 hasAuthorship W4387458558A5039964156 @default.
• W4387458558 hasAuthorship W4387458558A5045555988 @default.
• W4387458558 hasAuthorship W4387458558A5047814251 @default.
• W4387458558 hasAuthorship W4387458558A5053712155 @default.
• W4387458558 hasAuthorship W4387458558A5055246540 @default.
• W4387458558 hasAuthorship W4387458558A5063103135 @default.
• W4387458558 hasAuthorship W4387458558A5071449669 @default.
• W4387458558 hasAuthorship W4387458558A5073118412 @default.
• W4387458558 hasAuthorship W4387458558A5079524593 @default.
• W4387458558 hasAuthorship W4387458558A5090329560 @default.

• next