Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387459668> ?p ?o ?g. }
- W4387459668 endingPage "2974" @default.
- W4387459668 startingPage "2967" @default.
- W4387459668 abstract "To evaluate diacerein (interleukin-1β inhibitor) efficacy on ocular surface disease (OSD).This prospective observational study included patients who received diacerein for osteoarthritis and had dry eye (DE). The primary outcome was corneal staining score. Secondary outcomes were ocular surface disease index (OSDI) score, tear breakup time (TBUT), tear osmolarity (Osm), Schirmer's test results, interleukin-1α (IL-1α), interleukin-1β (IL-1β), and interleukin-1 receptor antagonist (IL-1Ra) levels in tears. All measurements were done at baseline and 2-month follow-up visits. Linear mixed models were used to examine the effect of all parameters, and log-transformed models were used for IL-1α, IL-1β, and IL-1Ra analyses.Thirty-four patients (31 females and 3 males) were enrolled. The corneal staining score improved by 1.29 points (P=0.022, 95% confidence interval [95% CI] 0.19 to 2.40) after 2 months, and the OSDI score improved by 17.2 points (P<0.001, 95% CI 10.82 to 23.58) but TUBT decreased by 0.66 seconds (P=0.021, 95% CI 0.10 to 1.22). No significant differences were observed in the tear Osm and Schirmer's test. IL-1Ra demonstrated no statistical difference, IL-1α was significantly increased by 80% (P=0.260), and IL-1β was significantly decreased by 99.21% (P<0.001).Diacerein can improve corneal staining and decrease IL-1β levels in tears, which reflects better DE symptoms. Diacerein may be a promising alternative treatment for patients with OSD and osteoarthritis." @default.
- W4387459668 created "2023-10-10" @default.
- W4387459668 creator A5034813082 @default.
- W4387459668 creator A5041479455 @default.
- W4387459668 creator A5045133249 @default.
- W4387459668 creator A5052987535 @default.
- W4387459668 creator A5078715041 @default.
- W4387459668 creator A5093029270 @default.
- W4387459668 date "2023-10-01" @default.
- W4387459668 modified "2023-10-18" @default.
- W4387459668 title "Efficacy of Interleukin-1β Inhibitor on Dry Eye Disease in Patients with Degenerative Arthritis" @default.
- W4387459668 cites W1413023120 @default.
- W4387459668 cites W145780728 @default.
- W4387459668 cites W156594437 @default.
- W4387459668 cites W1995118441 @default.
- W4387459668 cites W2005273232 @default.
- W4387459668 cites W2005352393 @default.
- W4387459668 cites W2014587146 @default.
- W4387459668 cites W2029495947 @default.
- W4387459668 cites W2031801691 @default.
- W4387459668 cites W2032002986 @default.
- W4387459668 cites W2038773696 @default.
- W4387459668 cites W2057311987 @default.
- W4387459668 cites W2060171402 @default.
- W4387459668 cites W2061445580 @default.
- W4387459668 cites W2091630088 @default.
- W4387459668 cites W2112003099 @default.
- W4387459668 cites W2112298497 @default.
- W4387459668 cites W2143545277 @default.
- W4387459668 cites W2270743897 @default.
- W4387459668 cites W2277988849 @default.
- W4387459668 cites W2328759903 @default.
- W4387459668 cites W2405455127 @default.
- W4387459668 cites W2411535932 @default.
- W4387459668 cites W2476591295 @default.
- W4387459668 cites W2479913883 @default.
- W4387459668 cites W2560219168 @default.
- W4387459668 cites W2598546209 @default.
- W4387459668 cites W2609896576 @default.
- W4387459668 cites W2737439597 @default.
- W4387459668 cites W2737787547 @default.
- W4387459668 cites W2738160893 @default.
- W4387459668 cites W2771968994 @default.
- W4387459668 cites W2809939128 @default.
- W4387459668 cites W2898151410 @default.
- W4387459668 cites W3012754900 @default.
- W4387459668 cites W3027480808 @default.
- W4387459668 cites W3121076261 @default.
- W4387459668 cites W3190148798 @default.
- W4387459668 cites W4294305402 @default.
- W4387459668 cites W4297791796 @default.
- W4387459668 cites W4365816777 @default.
- W4387459668 doi "https://doi.org/10.2147/opth.s419310" @default.
- W4387459668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37841899" @default.
- W4387459668 hasPublicationYear "2023" @default.
- W4387459668 type Work @default.
- W4387459668 citedByCount "0" @default.
- W4387459668 crossrefType "journal-article" @default.
- W4387459668 hasAuthorship W4387459668A5034813082 @default.
- W4387459668 hasAuthorship W4387459668A5041479455 @default.
- W4387459668 hasAuthorship W4387459668A5045133249 @default.
- W4387459668 hasAuthorship W4387459668A5052987535 @default.
- W4387459668 hasAuthorship W4387459668A5078715041 @default.
- W4387459668 hasAuthorship W4387459668A5093029270 @default.
- W4387459668 hasBestOaLocation W43874596681 @default.
- W4387459668 hasConcept C118487528 @default.
- W4387459668 hasConcept C126322002 @default.
- W4387459668 hasConcept C141071460 @default.
- W4387459668 hasConcept C142724271 @default.
- W4387459668 hasConcept C149892131 @default.
- W4387459668 hasConcept C170493617 @default.
- W4387459668 hasConcept C204787440 @default.
- W4387459668 hasConcept C2776164576 @default.
- W4387459668 hasConcept C2776885963 @default.
- W4387459668 hasConcept C2778122271 @default.
- W4387459668 hasConcept C2778275304 @default.
- W4387459668 hasConcept C2778690821 @default.
- W4387459668 hasConcept C44249647 @default.
- W4387459668 hasConcept C71924100 @default.
- W4387459668 hasConcept C74172505 @default.
- W4387459668 hasConcept C90924648 @default.
- W4387459668 hasConceptScore W4387459668C118487528 @default.
- W4387459668 hasConceptScore W4387459668C126322002 @default.
- W4387459668 hasConceptScore W4387459668C141071460 @default.
- W4387459668 hasConceptScore W4387459668C142724271 @default.
- W4387459668 hasConceptScore W4387459668C149892131 @default.
- W4387459668 hasConceptScore W4387459668C170493617 @default.
- W4387459668 hasConceptScore W4387459668C204787440 @default.
- W4387459668 hasConceptScore W4387459668C2776164576 @default.
- W4387459668 hasConceptScore W4387459668C2776885963 @default.
- W4387459668 hasConceptScore W4387459668C2778122271 @default.
- W4387459668 hasConceptScore W4387459668C2778275304 @default.
- W4387459668 hasConceptScore W4387459668C2778690821 @default.
- W4387459668 hasConceptScore W4387459668C44249647 @default.
- W4387459668 hasConceptScore W4387459668C71924100 @default.
- W4387459668 hasConceptScore W4387459668C74172505 @default.
- W4387459668 hasConceptScore W4387459668C90924648 @default.
- W4387459668 hasLocation W43874596681 @default.