FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387460522> ?p ?o ?g. }

• W4387460522 endingPage "995" @default.
• W4387460522 startingPage "995" @default.
• W4387460522 abstract "Aspergillus fumigatus is a ubiquitous, critical priority human fungal pathogen. Despite its clinical importance, there is limited knowledge regarding the variations of the genome within mitochondria, the powerhouse organelle within eukaryotic cells. In this study, we leveraged publicly available, raw, whole genome sequence data isolates from 1939 to investigate the variations in the mitochondrial genomes of A. fumigatus. These isolates were isolated from 22 countries on six continents, as well as from outer space and from within the International Space Station. In total, our analysis revealed 39 mitochondrial single nucleotide polymorphisms (mtSNPs) within this global sample, and, together, these 39 mtSNPs grouped the 1939 isolates into 79 mitochondrial multilocus genotypes (MLGs). Among the 79 MLGs, 39 were each distributed in at least two countries and 30 were each shared by at least two continents. The two most frequent MLGs were also broadly distributed: MLG11 represented 420 isolates from 11 countries and four continents and while MLG79 represented 418 isolates from 18 countries and five continents, consistent with long-distance dispersals of mitogenomes. Our population genetic analyses of the mtSNPs revealed limited differentiation among continental populations, but highly variable genetic differences among national populations, largely due to localized clonal expansions of different MLGs. Phylogenetic analysis and Discriminant Analysis of Principal Components of mtSNPs suggested the presence of at least three mitogenome clusters. Linkage disequilibrium, Index of Association, and phylogenetic incompatibility analyses collectively suggested evidence for mitogenome recombination in natural populations of A. fumigatus. In addition, sequence read depth analyses revealed an average ratio of ~20 mitogenomes per nuclear genome in this global population, but the ratios varied among strains within and between certain geographic populations. Together, our results suggest evidence for organelle dynamics, genetic differentiation, recombination, and both widespread and localized clonal expansion of the mitogenomes in the global A. fumigatus population." @default.
• W4387460522 created "2023-10-10" @default.
• W4387460522 creator A5068107262 @default.
• W4387460522 creator A5092896238 @default.
• W4387460522 date "2023-10-08" @default.
• W4387460522 modified "2023-10-11" @default.
• W4387460522 title "Mitogenome Variations in a Global Population of Aspergillus fumigatus" @default.
• W4387460522 cites W1820106810 @default.
• W4387460522 cites W1883839492 @default.
• W4387460522 cites W1943133705 @default.
• W4387460522 cites W1965072041 @default.
• W4387460522 cites W1977601452 @default.
• W4387460522 cites W2008401520 @default.
• W4387460522 cites W2016603972 @default.
• W4387460522 cites W2017567054 @default.
• W4387460522 cites W2037310029 @default.
• W4387460522 cites W2042082512 @default.
• W4387460522 cites W2043294213 @default.
• W4387460522 cites W2059774589 @default.
• W4387460522 cites W2060926807 @default.
• W4387460522 cites W2065659813 @default.
• W4387460522 cites W2070407727 @default.
• W4387460522 cites W2099901798 @default.
• W4387460522 cites W2100979324 @default.
• W4387460522 cites W2108313755 @default.
• W4387460522 cites W2119180969 @default.
• W4387460522 cites W2132466944 @default.
• W4387460522 cites W2138935782 @default.
• W4387460522 cites W2140101678 @default.
• W4387460522 cites W2141197648 @default.
• W4387460522 cites W2158535397 @default.
• W4387460522 cites W2170093840 @default.
• W4387460522 cites W2412202321 @default.
• W4387460522 cites W2415728719 @default.
• W4387460522 cites W2509945899 @default.
• W4387460522 cites W2535298532 @default.
• W4387460522 cites W2545616412 @default.
• W4387460522 cites W2583467547 @default.
• W4387460522 cites W2780456459 @default.
• W4387460522 cites W2794825758 @default.
• W4387460522 cites W2883251903 @default.
• W4387460522 cites W2892202829 @default.
• W4387460522 cites W2899883312 @default.
• W4387460522 cites W2951912016 @default.
• W4387460522 cites W2987344665 @default.
• W4387460522 cites W3020729888 @default.
• W4387460522 cites W3091989759 @default.
• W4387460522 cites W3092864100 @default.
• W4387460522 cites W3109712310 @default.
• W4387460522 cites W3110009740 @default.
• W4387460522 cites W3131055609 @default.
• W4387460522 cites W3156458251 @default.
• W4387460522 cites W3179219075 @default.
• W4387460522 cites W3216606044 @default.
• W4387460522 cites W4224669774 @default.
• W4387460522 cites W4250440988 @default.
• W4387460522 cites W4282982497 @default.
• W4387460522 cites W4296833020 @default.
• W4387460522 cites W4308153469 @default.
• W4387460522 cites W4309231568 @default.
• W4387460522 doi "https://doi.org/10.3390/jof9100995" @default.
• W4387460522 hasPublicationYear "2023" @default.
• W4387460522 type Work @default.
• W4387460522 citedByCount "0" @default.
• W4387460522 crossrefType "journal-article" @default.
• W4387460522 hasAuthorship W4387460522A5068107262 @default.
• W4387460522 hasAuthorship W4387460522A5092896238 @default.
• W4387460522 hasBestOaLocation W43874605221 @default.
• W4387460522 hasConcept C104317684 @default.
• W4387460522 hasConcept C135763542 @default.
• W4387460522 hasConcept C141231307 @default.
• W4387460522 hasConcept C144024400 @default.
• W4387460522 hasConcept C149923435 @default.
• W4387460522 hasConcept C193252679 @default.
• W4387460522 hasConcept C197754878 @default.
• W4387460522 hasConcept C24586158 @default.
• W4387460522 hasConcept C2779787849 @default.
• W4387460522 hasConcept C2908647359 @default.
• W4387460522 hasConcept C35605836 @default.
• W4387460522 hasConcept C54355233 @default.
• W4387460522 hasConcept C77434933 @default.
• W4387460522 hasConcept C78458016 @default.
• W4387460522 hasConcept C86803240 @default.
• W4387460522 hasConcept C89423630 @default.
• W4387460522 hasConcept C90132467 @default.
• W4387460522 hasConceptScore W4387460522C104317684 @default.
• W4387460522 hasConceptScore W4387460522C135763542 @default.
• W4387460522 hasConceptScore W4387460522C141231307 @default.
• W4387460522 hasConceptScore W4387460522C144024400 @default.
• W4387460522 hasConceptScore W4387460522C149923435 @default.
• W4387460522 hasConceptScore W4387460522C193252679 @default.
• W4387460522 hasConceptScore W4387460522C197754878 @default.
• W4387460522 hasConceptScore W4387460522C24586158 @default.
• W4387460522 hasConceptScore W4387460522C2779787849 @default.
• W4387460522 hasConceptScore W4387460522C2908647359 @default.
• W4387460522 hasConceptScore W4387460522C35605836 @default.
• W4387460522 hasConceptScore W4387460522C54355233 @default.
• W4387460522 hasConceptScore W4387460522C77434933 @default.

• next