Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387461010> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4387461010 abstract "Cholera, a diarrhoeal disease caused by gram-negative bacterium Vibrio cholerae remains a global health threat in developing countries owing to its high transmissibility and increase in antibiotic resistance. The current issue is to overcome the problem of resistance by antimicrobial therapy. There is a need for alternative strategies with an emphasis on anti-virulent approaches to alter the outcome of bacterial infections. Vibrio cholerae causes cholera by secreting virulence factors in the intestinal epithelial cells. Virulence factors help in cholera toxin production and colonisation during infection. Here, we show that sodium butyrate (SB), a small molecule, had no effect on bacterial viability but was effective in suppressing the virulence attributes of V. cholerae. The production of cholera toxin (CT) was downregulated in a standard V. cholerae El Tor strain and two clinical isolates when grown in presence of sodium butyrate. Analysis of mRNA and protein levels further demonstrated that sodium butyrate reduced the expression of the ToxT-dependent virulence genes like tcpA and ctxAB. DNA-protein interaction assays conducted at cellular (ChIP) and in in vitro conditions (EMSA) indicated that sodium butyrate weakens the binding between ToxT and its downstream promoter DNA, likely by blocking DNA binding. Furthermore, the efficacy of sodium butyrate was confirmed by showing its anti-virulence activity and tissue damage recovery in animal models. Collectively, these findings suggest that sodium butyrate (SB) has the potential to be developed as an anti-virulence agent against V. cholerae in place of conventional antibiotics or as an adjunctive therapy to combat cholera." @default.
- W4387461010 created "2023-10-10" @default.
- W4387461010 creator A5004135057 @default.
- W4387461010 creator A5016184878 @default.
- W4387461010 creator A5044602167 @default.
- W4387461010 creator A5047411963 @default.
- W4387461010 creator A5051956799 @default.
- W4387461010 creator A5057755199 @default.
- W4387461010 creator A5070409772 @default.
- W4387461010 creator A5075441311 @default.
- W4387461010 creator A5075987933 @default.
- W4387461010 creator A5089967855 @default.
- W4387461010 date "2023-10-06" @default.
- W4387461010 modified "2023-10-11" @default.
- W4387461010 title "Potential use of Sodium Butyrate (SB) as an anti-virulence agent against<i>Vibrio cholerae</i>targeting ToxT virulence protein." @default.
- W4387461010 doi "https://doi.org/10.1101/2023.10.05.561138" @default.
- W4387461010 hasPublicationYear "2023" @default.
- W4387461010 type Work @default.
- W4387461010 citedByCount "0" @default.
- W4387461010 crossrefType "posted-content" @default.
- W4387461010 hasAuthorship W4387461010A5004135057 @default.
- W4387461010 hasAuthorship W4387461010A5016184878 @default.
- W4387461010 hasAuthorship W4387461010A5044602167 @default.
- W4387461010 hasAuthorship W4387461010A5047411963 @default.
- W4387461010 hasAuthorship W4387461010A5051956799 @default.
- W4387461010 hasAuthorship W4387461010A5057755199 @default.
- W4387461010 hasAuthorship W4387461010A5070409772 @default.
- W4387461010 hasAuthorship W4387461010A5075441311 @default.
- W4387461010 hasAuthorship W4387461010A5075987933 @default.
- W4387461010 hasAuthorship W4387461010A5089967855 @default.
- W4387461010 hasBestOaLocation W43874610101 @default.
- W4387461010 hasConcept C100544194 @default.
- W4387461010 hasConcept C104317684 @default.
- W4387461010 hasConcept C2776979534 @default.
- W4387461010 hasConcept C2777006276 @default.
- W4387461010 hasConcept C2778643871 @default.
- W4387461010 hasConcept C2778942008 @default.
- W4387461010 hasConcept C2780722889 @default.
- W4387461010 hasConcept C2781090273 @default.
- W4387461010 hasConcept C523546767 @default.
- W4387461010 hasConcept C54355233 @default.
- W4387461010 hasConcept C55493867 @default.
- W4387461010 hasConcept C60987743 @default.
- W4387461010 hasConcept C86803240 @default.
- W4387461010 hasConcept C89423630 @default.
- W4387461010 hasConceptScore W4387461010C100544194 @default.
- W4387461010 hasConceptScore W4387461010C104317684 @default.
- W4387461010 hasConceptScore W4387461010C2776979534 @default.
- W4387461010 hasConceptScore W4387461010C2777006276 @default.
- W4387461010 hasConceptScore W4387461010C2778643871 @default.
- W4387461010 hasConceptScore W4387461010C2778942008 @default.
- W4387461010 hasConceptScore W4387461010C2780722889 @default.
- W4387461010 hasConceptScore W4387461010C2781090273 @default.
- W4387461010 hasConceptScore W4387461010C523546767 @default.
- W4387461010 hasConceptScore W4387461010C54355233 @default.
- W4387461010 hasConceptScore W4387461010C55493867 @default.
- W4387461010 hasConceptScore W4387461010C60987743 @default.
- W4387461010 hasConceptScore W4387461010C86803240 @default.
- W4387461010 hasConceptScore W4387461010C89423630 @default.
- W4387461010 hasLocation W43874610101 @default.
- W4387461010 hasOpenAccess W4387461010 @default.
- W4387461010 hasPrimaryLocation W43874610101 @default.
- W4387461010 hasRelatedWork W1548133190 @default.
- W4387461010 hasRelatedWork W1758049144 @default.
- W4387461010 hasRelatedWork W1936517735 @default.
- W4387461010 hasRelatedWork W1992766527 @default.
- W4387461010 hasRelatedWork W2068811528 @default.
- W4387461010 hasRelatedWork W2089129210 @default.
- W4387461010 hasRelatedWork W2124989251 @default.
- W4387461010 hasRelatedWork W2393289173 @default.
- W4387461010 hasRelatedWork W2408603146 @default.
- W4387461010 hasRelatedWork W3030874125 @default.
- W4387461010 isParatext "false" @default.
- W4387461010 isRetracted "false" @default.
- W4387461010 workType "article" @default.