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• W4387461301 abstract "<p><i>MALAT1</i> depletion impairs HR-mediated DSB repair in prostate cancer cells. <b>A,</b> DAVID analysis depicting biological pathways downregulated in LNCaP-abl-si<i>MALAT1</i> cells relative to LNCaP-abl–siCTL. Bars represent -log₁₀ (<i>P</i>) and the frequency polygon (line in orange) represents the number of genes. <b>B,</b> Correlogram depicting Pearson correlation coefficient (<i>ρ</i>) between DNA repair–associated genes and <i>MALAT1</i> in prostate cancer patient samples from GSE35988 and GSE3325 datasets (FDR adjusted, <i>P</i> < 0.05). Correlation coefficients are expressed by the color from red to blue and the dot size is proportional to the strength of the correlation. Representative genes are marked on the sides of the correlogram. <b>C,</b> Representative confocal images for γH2AX foci (green) in control and <i>MALAT1</i>-ablated 22RV1 and LNCaP cells. The nucleus was visualized by DAPI (blue). Scale bar, 10 µm. <b>D,</b> Quantification of the number of γH2AX-positive foci in the indicated cells. Bar plot showing the percentage of cells with the indicated number of foci/nuclei in the same cells. The <i>P</i> value for the χ² test is indicated. <b>E,</b> Immunoblots showing the expression of HR markers in <i>MALAT1</i>-silenced and shSCRM prostate cancer cells. β-Actin was used as a loading control. <b>F,</b> Same as C, except immunostaining for BRCA1. <b>G,</b> Same as C, except immuno-staining for RAD51. <b>H,</b> Schematic of the pDR-GFP reporter used to monitor HR activity in 22RV1 <i>MALAT1</i>-KO and shRAD51 cells. Bar plot exhibiting the percentage of GFP⁺ cells in 22RV1-<i>MALAT1</i>-KO and shRAD51 cells transfected with pDR-GFP reporter construct. Experiments were performed with <i>n</i> = 3 biologically independent samples; the data represent mean ± SEM. For D and F–H, one-way ANOVA with Dunnett multiple comparisons <i>posthoc</i> test was applied while the χ² test was used for D.</p>" @default.
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• W4387461301 date "2023-10-09" @default.
• W4387461301 modified "2023-10-11" @default.
• W4387461301 title "FIGURE 3 from Targeting <i>MALAT1</i> Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer" @default.
• W4387461301 doi "https://doi.org/10.1158/2767-9764.24272023" @default.
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