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- W4387467535 abstract "The treatment landscape of metastatic renal cell carcinoma (mRCC) has evolved rapidly over the last decade. For a long time, targeted monotherapy with vascular endothelial growth factor (VEGF)-tyrosine kinase inhibitors (TKIs) such as sunitinib, pazopanib, and cabozantinib was considered the predominant and preferred frontline treatment options. However, combination treatments including doublet PD-1/L1 and CTLA-4 inhibitor ipilimumab immune checkpoint inhibitors (ICIs) or VEGF-TKI combined with PD-1/L1 inhibitors have further improved the response rates, durability of response, as well as overall survival and now are the preferred first-line therapies. Modest advances have also occurred in the therapy of nonclear cell (ncc)-RCC by the incorporation of VEGF inhibitors and ICIs in the therapeutic armamentarium. Here, we discuss the data on all available treatment options for patients with mRCC and provide a contemporary perspective on the optimal approach to manage these patients." @default.
- W4387467535 created "2023-10-10" @default.
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- W4387467535 date "2023-01-01" @default.
- W4387467535 modified "2023-10-11" @default.
- W4387467535 title "Management of Metastatic Renal Cell Carcinoma" @default.
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- W4387467535 doi "https://doi.org/10.1007/978-981-99-2341-0_4" @default.
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