Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387470122> ?p ?o ?g. }
- W4387470122 endingPage "88" @default.
- W4387470122 startingPage "80" @default.
- W4387470122 abstract "Inhibition of the MAPK pathway by MEK inhibitors (MEKi) is currently a therapeutic standard in several cancer types, including ovarian low-grade serous carcinoma (LGSC). A common MAPK pathway alteration in tubo-ovarian high-grade serous carcinoma (HGSC) is the genomic inactivation of neurofibromin 1 (NF1). The primary objectives of our study were to survey the prevalence of NF1 inactivation in the principal ovarian carcinoma histotype as well as to evaluate its associations with clinico-pathological parameters and key biomarkers including BRCA1/2 status in HGSC.A recently commercialized NF1 antibody (clone NFC) was orthogonally validated on an automated immunohistochemistry (IHC) platform and IHC was performed on tissue microarrays containing 2140 ovarian carcinoma cases. Expression was interpreted as loss/inactivated (complete or subclonal) versus normal/retained.Loss of NF1 expression was detected in 250/1429 (17.4%) HGSC including 11% with subclonal loss. Survival of NF1-inactivated HGSC patients was intermediate between favorable BRCA1/2 mutated HGSC and unfavorable CCNE1 high-level amplified HGSC. NF1 inactivation was mutually exclusive with CCNE1 high-level amplifications, co-occurred with RB1 loss and occurred at similar frequencies in BRCA1/2 mutated versus wild-type HGSC. NF1 loss was found in 21/286 (7.3%) endometrioid carcinomas with a favorable prognostic association (p = 0.048), and in 4/64 (5.9%) LGSC, mutually exclusive with other driver events.NF1 inactivation occurs in a significant subset of BRCA1/2 wild-type HGSC and a subset of LGSC. While the functional effects of NF1 inactivation need to be further characterized, this signifies a potential therapeutic opportunity to explore targeting NF1 inactivation in these tumors." @default.
- W4387470122 created "2023-10-10" @default.
- W4387470122 creator A5001581898 @default.
- W4387470122 creator A5011298754 @default.
- W4387470122 creator A5015851482 @default.
- W4387470122 creator A5018264282 @default.
- W4387470122 creator A5019866784 @default.
- W4387470122 creator A5019905621 @default.
- W4387470122 creator A5026729348 @default.
- W4387470122 creator A5027382545 @default.
- W4387470122 creator A5028408259 @default.
- W4387470122 creator A5030619864 @default.
- W4387470122 creator A5037627456 @default.
- W4387470122 creator A5045343897 @default.
- W4387470122 creator A5056148870 @default.
- W4387470122 creator A5083732133 @default.
- W4387470122 creator A5086449500 @default.
- W4387470122 creator A5087809113 @default.
- W4387470122 date "2023-11-01" @default.
- W4387470122 modified "2023-10-18" @default.
- W4387470122 title "Survey of NF1 inactivation by surrogate immunohistochemistry in ovarian carcinomas" @default.
- W4387470122 cites W1781764024 @default.
- W4387470122 cites W1979693095 @default.
- W4387470122 cites W203558097 @default.
- W4387470122 cites W2039785378 @default.
- W4387470122 cites W2041440766 @default.
- W4387470122 cites W2088060771 @default.
- W4387470122 cites W2123696077 @default.
- W4387470122 cites W2144796447 @default.
- W4387470122 cites W2149441684 @default.
- W4387470122 cites W2153954237 @default.
- W4387470122 cites W2299201707 @default.
- W4387470122 cites W2412393832 @default.
- W4387470122 cites W2417320495 @default.
- W4387470122 cites W2518044343 @default.
- W4387470122 cites W2593905043 @default.
- W4387470122 cites W2653933210 @default.
- W4387470122 cites W2750707378 @default.
- W4387470122 cites W2765304775 @default.
- W4387470122 cites W2769136370 @default.
- W4387470122 cites W2782665025 @default.
- W4387470122 cites W2794460351 @default.
- W4387470122 cites W2913813529 @default.
- W4387470122 cites W2937832733 @default.
- W4387470122 cites W2953270703 @default.
- W4387470122 cites W2970379806 @default.
- W4387470122 cites W3021307559 @default.
- W4387470122 cites W3025278159 @default.
- W4387470122 cites W3085809921 @default.
- W4387470122 cites W3137503175 @default.
- W4387470122 cites W3212610509 @default.
- W4387470122 cites W4226022025 @default.
- W4387470122 cites W4285026485 @default.
- W4387470122 cites W4286461992 @default.
- W4387470122 cites W4304136287 @default.
- W4387470122 cites W4309656101 @default.
- W4387470122 cites W4312210137 @default.
- W4387470122 cites W4353029051 @default.
- W4387470122 doi "https://doi.org/10.1016/j.ygyno.2023.09.016" @default.
- W4387470122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37820398" @default.
- W4387470122 hasPublicationYear "2023" @default.
- W4387470122 type Work @default.
- W4387470122 citedByCount "0" @default.
- W4387470122 crossrefType "journal-article" @default.
- W4387470122 hasAuthorship W4387470122A5001581898 @default.
- W4387470122 hasAuthorship W4387470122A5011298754 @default.
- W4387470122 hasAuthorship W4387470122A5015851482 @default.
- W4387470122 hasAuthorship W4387470122A5018264282 @default.
- W4387470122 hasAuthorship W4387470122A5019866784 @default.
- W4387470122 hasAuthorship W4387470122A5019905621 @default.
- W4387470122 hasAuthorship W4387470122A5026729348 @default.
- W4387470122 hasAuthorship W4387470122A5027382545 @default.
- W4387470122 hasAuthorship W4387470122A5028408259 @default.
- W4387470122 hasAuthorship W4387470122A5030619864 @default.
- W4387470122 hasAuthorship W4387470122A5037627456 @default.
- W4387470122 hasAuthorship W4387470122A5045343897 @default.
- W4387470122 hasAuthorship W4387470122A5056148870 @default.
- W4387470122 hasAuthorship W4387470122A5083732133 @default.
- W4387470122 hasAuthorship W4387470122A5086449500 @default.
- W4387470122 hasAuthorship W4387470122A5087809113 @default.
- W4387470122 hasBestOaLocation W43874701221 @default.
- W4387470122 hasConcept C121608353 @default.
- W4387470122 hasConcept C126322002 @default.
- W4387470122 hasConcept C143998085 @default.
- W4387470122 hasConcept C150173356 @default.
- W4387470122 hasConcept C193270364 @default.
- W4387470122 hasConcept C204232928 @default.
- W4387470122 hasConcept C2777632260 @default.
- W4387470122 hasConcept C2780427987 @default.
- W4387470122 hasConcept C3019054536 @default.
- W4387470122 hasConcept C502942594 @default.
- W4387470122 hasConcept C71924100 @default.
- W4387470122 hasConceptScore W4387470122C121608353 @default.
- W4387470122 hasConceptScore W4387470122C126322002 @default.
- W4387470122 hasConceptScore W4387470122C143998085 @default.
- W4387470122 hasConceptScore W4387470122C150173356 @default.
- W4387470122 hasConceptScore W4387470122C193270364 @default.
- W4387470122 hasConceptScore W4387470122C204232928 @default.