FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387472443> ?p ?o ?g. }

• W4387472443 abstract "X-linked hypophosphatemia (XLH) is a rare disease of elevated fibroblast growth factor 23 (FGF23) production that leads to hypophosphatemia and impaired mineralization of bone and teeth. The clinical manifestations of XLH include a high prevalence of dental abscesses and periodontal disease, likely driven by poorly formed structures of the dentoalveolar complex, including the alveolar bone, cementum, dentin, and periodontal ligament. Our previous studies have demonstrated that sclerostin antibody (Scl-Ab) treatment improves phosphate homeostasis, and increases long bone mass, strength, and mineralization in the Hyp mouse model of XLH. In the current study, we investigated whether Scl-Ab impacts the dentoalveolar structures of Hyp mice. Male and female wild-type and Hyp littermates were injected with 25 mg·kg-1 of vehicle or Scl-Ab twice weekly beginning at 12 weeks of age and euthanized at 20 weeks of age. Scl-Ab increased alveolar bone mass in both male and female mice and alveolar tissue mineral density in the male mice. The positive effects of Scl-Ab were consistent with an increase in the fraction of active (nonphosphorylated) β-catenin, dentin matrix protein 1 (DMP1) and osteopontin stained alveolar osteocytes. Scl-Ab had no effect on the mass and mineralization of dentin, enamel, acellular or cellular cementum. There was a nonsignificant trend toward increased periodontal ligament (PDL) attachment fraction within the Hyp mice. Additional PDL fiber structural parameters were not affected by Scl-Ab. The current study demonstrates that Scl-Ab can improve alveolar bone in adult Hyp mice." @default.
• W4387472443 created "2023-10-11" @default.
• W4387472443 creator A5010274982 @default.
• W4387472443 creator A5016126152 @default.
• W4387472443 creator A5018666528 @default.
• W4387472443 creator A5018871195 @default.
• W4387472443 creator A5026950221 @default.
• W4387472443 creator A5053761345 @default.
• W4387472443 creator A5065525714 @default.
• W4387472443 creator A5072303198 @default.
• W4387472443 date "2023-10-10" @default.
• W4387472443 modified "2023-10-13" @default.
• W4387472443 title "Sclerostin antibody improves alveolar bone quality in the Hyp mouse model of X-linked hypophosphatemia (XLH)" @default.
• W4387472443 cites W1970180916 @default.
• W4387472443 cites W1972086586 @default.
• W4387472443 cites W1985742682 @default.
• W4387472443 cites W2002733443 @default.
• W4387472443 cites W2006531162 @default.
• W4387472443 cites W2023186025 @default.
• W4387472443 cites W2046762879 @default.
• W4387472443 cites W2046854220 @default.
• W4387472443 cites W2050698413 @default.
• W4387472443 cites W2055982591 @default.
• W4387472443 cites W2058611644 @default.
• W4387472443 cites W2061449923 @default.
• W4387472443 cites W2068916684 @default.
• W4387472443 cites W2078921740 @default.
• W4387472443 cites W2081594039 @default.
• W4387472443 cites W2083190965 @default.
• W4387472443 cites W2089307105 @default.
• W4387472443 cites W2108403721 @default.
• W4387472443 cites W2114309748 @default.
• W4387472443 cites W2130665218 @default.
• W4387472443 cites W2130807386 @default.
• W4387472443 cites W2137455986 @default.
• W4387472443 cites W2139652400 @default.
• W4387472443 cites W2153703573 @default.
• W4387472443 cites W2155036045 @default.
• W4387472443 cites W2170802720 @default.
• W4387472443 cites W2208671986 @default.
• W4387472443 cites W2269306832 @default.
• W4387472443 cites W2295099957 @default.
• W4387472443 cites W2518062514 @default.
• W4387472443 cites W2552211559 @default.
• W4387472443 cites W2553770402 @default.
• W4387472443 cites W2557065026 @default.
• W4387472443 cites W2741484922 @default.
• W4387472443 cites W2786048911 @default.
• W4387472443 cites W2942406721 @default.
• W4387472443 cites W2943998355 @default.
• W4387472443 cites W2946559089 @default.
• W4387472443 cites W2989238464 @default.
• W4387472443 cites W2991367422 @default.
• W4387472443 cites W3002331783 @default.
• W4387472443 cites W3033218544 @default.
• W4387472443 cites W3127503803 @default.
• W4387472443 cites W3138587309 @default.
• W4387472443 cites W3157211768 @default.
• W4387472443 cites W3187202809 @default.
• W4387472443 cites W3199869492 @default.
• W4387472443 cites W3212636725 @default.
• W4387472443 cites W4226192958 @default.
• W4387472443 cites W4229439314 @default.
• W4387472443 cites W4288430909 @default.
• W4387472443 cites W4328116259 @default.
• W4387472443 doi "https://doi.org/10.1038/s41368-023-00252-1" @default.
• W4387472443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37813865" @default.
• W4387472443 hasPublicationYear "2023" @default.
• W4387472443 type Work @default.
• W4387472443 citedByCount "0" @default.
• W4387472443 crossrefType "journal-article" @default.
• W4387472443 hasAuthorship W4387472443A5010274982 @default.
• W4387472443 hasAuthorship W4387472443A5016126152 @default.
• W4387472443 hasAuthorship W4387472443A5018666528 @default.
• W4387472443 hasAuthorship W4387472443A5018871195 @default.
• W4387472443 hasAuthorship W4387472443A5026950221 @default.
• W4387472443 hasAuthorship W4387472443A5053761345 @default.
• W4387472443 hasAuthorship W4387472443A5065525714 @default.
• W4387472443 hasAuthorship W4387472443A5072303198 @default.
• W4387472443 hasBestOaLocation W43874724431 @default.
• W4387472443 hasConcept C104317684 @default.
• W4387472443 hasConcept C126322002 @default.
• W4387472443 hasConcept C134018914 @default.
• W4387472443 hasConcept C137620995 @default.
• W4387472443 hasConcept C142724271 @default.
• W4387472443 hasConcept C151279780 @default.
• W4387472443 hasConcept C185592680 @default.
• W4387472443 hasConcept C199343813 @default.
• W4387472443 hasConcept C203014093 @default.
• W4387472443 hasConcept C2522874641 @default.
• W4387472443 hasConcept C2777267240 @default.
• W4387472443 hasConcept C2777894202 @default.
• W4387472443 hasConcept C2778573388 @default.
• W4387472443 hasConcept C2779263046 @default.
• W4387472443 hasConcept C2779277721 @default.
• W4387472443 hasConcept C2780804394 @default.
• W4387472443 hasConcept C41868710 @default.
• W4387472443 hasConcept C55493867 @default.
• W4387472443 hasConcept C68434959 @default.
• W4387472443 hasConcept C71924100 @default.

• next