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- W4387472499 abstract "SQSTM1/p62 bodies are phase-separated condensates that play a fundamental role in intracellular quality control and stress responses. Despite extensive studies investigating the mechanism of formation and degradation of SQSTM1/p62 bodies, the constituents of SQSTM1/p62 bodies remain elusive. We recently developed a purification method for intracellular SQSTM1/p62 bodies using a cell sorter and identified their constituents by mass spectrometry. Combined with mass spectrometry of tissues from selective autophagy-deficient mice, we identified vault, a ubiquitous non-membranous organelle composed of proteins and non-coding RNA, as a novel substrate for selective autophagy. Vault directly binds to NBR1, an SQSTM1/p62 binding partner recruited to SQSTM1/p62 bodies, and is subsequently degraded by selective autophagy dependent on the phase separation of SQSTM1/p62. We named this process vault-phagy and found that defects in vault-phagy are related to nonalcoholic steatohepatitis (NASH)-derived hepatocellular carcinoma. Our method for purifying SQSTM1/p62 bodies will contribute to elucidating the mechanisms of several stress responses and diseases mediated by SQSTM1/p62 bodies." @default.
- W4387472499 created "2023-10-11" @default.
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- W4387472499 date "2023-10-10" @default.
- W4387472499 modified "2023-10-16" @default.
- W4387472499 title "Vault-phagy: a phase-separation-mediated selective autophagy of vault, a non-membranous organelle" @default.
- W4387472499 cites W4376605108 @default.
- W4387472499 doi "https://doi.org/10.1080/15548627.2023.2266996" @default.
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