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- W4387472566 abstract "Abstract Working memory (WM) impairment has been well characterized in normal aging. Various studies have explored changes in either the regional activity or the interregional connectivity underlying the aging process of WM. We proposed that brain activity and connectivity would independently alter with aging and affect WM performance. WM was assessed with a classical N‐back task during functional magnetic resonance imaging in a community‐based sample comprising 168 elderly subjects (aged 55–86 years old). Following the rationale of background functional connectivity, we assessed age‐related alterations in brain activity and seed‐based interregional connectivity independently. Analyses revealed age‐related decrease in positive activity of the inferior parietal lobule (IPL) and an increase in the negative activity of the ventral anterior cingulate cortex (ACC), and the local functional dysfunctions were accompanied by alterations in their connectivity to other cortical regions. Importantly, regional activity impairments in the IPL and ACC could mediate age‐related effects on accuracy rate and reaction time, respectively, and those effects were further counterbalanced by enhancement of their background functional connectivity. We thus claimed that age‐induced alterations in regional activity and interregional connectivity occurred independently and contributed to WM changes in aging. Our findings presented the way brain activity and functional connectivity interact in the late adulthood, thus providing a new perspective for understanding WM and cognitive aging." @default.
- W4387472566 created "2023-10-11" @default.
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- W4387472566 date "2023-10-09" @default.
- W4387472566 modified "2023-10-16" @default.
- W4387472566 title "Joint contributions from brain activity and activity‐independent functional connectivity to working memory aging" @default.
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- W4387472566 doi "https://doi.org/10.1111/psyp.14449" @default.
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