FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387472583> ?p ?o ?g. }

• W4387472583 abstract "Many studies have found that dietary fiber can protect against colorectal cancer (CRC). Survival in CRC patients is significantly reduced due to metastasis. However, little is known regarding the impact of dietary fiber on the CRC metastasis. In this study, we analyzed the effects of inulin, cellulose, and their mixture on CRC metastasis in a murine orthotopic transplantation model. BALB/C male mice were divided into the normal control (NC) (AIN-93 M diet), MOD (AIN-93 M diet), INU (10% w/w inulin), CEL (10% w/w cellulose), and MIX (5% w/w inulin + 5% w/w cellulose) groups. Dietary fiber intake inhibited the weights of the orthotopic tumors, liver weights, and liver metastasis area (p < 0.05) and improved the survival rate of tumor-bearing mice. Compared to the NC, the expression of β-catenin and the epithelial marker E-cadherin were lower, and that of mesenchymal markers, such as N-cadherin, MMP-9, and VEGF, were higher in the MOD group. All inulin, cellulose, and their mixture restored the gut microbiota diversity, and they, respectively, increased the relative abundance of Bifidobacteriales, Lactobacillus, and Lachnospiraceae. Inulin restored the levels of acetic acid, propionic acid, isobutyric acid, and butyric acid. Spearman correlation analysis results showed that there was a positive correlation between five genera and six short-chain fatty acids (SCFAs) (adjusted p < 0.05). In conclusion, all inulin, cellulose, and their mixture have inhibitory effects on CRC metastasis, which may be achieved by the regulation of gut microbiota, the production of SCFAs, and the inhibition of the epithelial-to-mesenchymal transition process. Among the three dietary fiber intervention groups, the inhibitory effect of inulin is more significant." @default.
• W4387472583 created "2023-10-11" @default.
• W4387472583 creator A5012829362 @default.
• W4387472583 creator A5017476303 @default.
• W4387472583 creator A5029397237 @default.
• W4387472583 creator A5030024340 @default.
• W4387472583 creator A5030955032 @default.
• W4387472583 creator A5055838753 @default.
• W4387472583 creator A5066991838 @default.
• W4387472583 creator A5079815759 @default.
• W4387472583 creator A5085441351 @default.
• W4387472583 creator A5091146770 @default.
• W4387472583 date "2023-10-10" @default.
• W4387472583 modified "2023-10-17" @default.
• W4387472583 title "The preventive effects of inulin, cellulose, and their mixture on colorectal cancer liver metastasis in mice by regulating gut microbiota" @default.
• W4387472583 cites W1751184252 @default.
• W4387472583 cites W1978678012 @default.
• W4387472583 cites W1981266729 @default.
• W4387472583 cites W2000067794 @default.
• W4387472583 cites W2002703043 @default.
• W4387472583 cites W2028684673 @default.
• W4387472583 cites W2045119680 @default.
• W4387472583 cites W2055251230 @default.
• W4387472583 cites W2057156320 @default.
• W4387472583 cites W2060469376 @default.
• W4387472583 cites W2080275318 @default.
• W4387472583 cites W2154075765 @default.
• W4387472583 cites W2160595883 @default.
• W4387472583 cites W2285317564 @default.
• W4387472583 cites W2338773685 @default.
• W4387472583 cites W2518317611 @default.
• W4387472583 cites W2576118052 @default.
• W4387472583 cites W2586155766 @default.
• W4387472583 cites W2611952773 @default.
• W4387472583 cites W2743502656 @default.
• W4387472583 cites W2914662350 @default.
• W4387472583 cites W2924716708 @default.
• W4387472583 cites W3023195047 @default.
• W4387472583 cites W3029249211 @default.
• W4387472583 cites W3128646645 @default.
• W4387472583 cites W3138137747 @default.
• W4387472583 cites W3153136144 @default.
• W4387472583 cites W3179132743 @default.
• W4387472583 cites W3207326889 @default.
• W4387472583 cites W3214085000 @default.
• W4387472583 cites W393883301 @default.
• W4387472583 cites W4294219229 @default.
• W4387472583 cites W4309680810 @default.
• W4387472583 doi "https://doi.org/10.1111/1750-3841.16772" @default.
• W4387472583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37815692" @default.
• W4387472583 hasPublicationYear "2023" @default.
• W4387472583 type Work @default.
• W4387472583 citedByCount "0" @default.
• W4387472583 crossrefType "journal-article" @default.
• W4387472583 hasAuthorship W4387472583A5012829362 @default.
• W4387472583 hasAuthorship W4387472583A5017476303 @default.
• W4387472583 hasAuthorship W4387472583A5029397237 @default.
• W4387472583 hasAuthorship W4387472583A5030024340 @default.
• W4387472583 hasAuthorship W4387472583A5030955032 @default.
• W4387472583 hasAuthorship W4387472583A5055838753 @default.
• W4387472583 hasAuthorship W4387472583A5066991838 @default.
• W4387472583 hasAuthorship W4387472583A5079815759 @default.
• W4387472583 hasAuthorship W4387472583A5085441351 @default.
• W4387472583 hasAuthorship W4387472583A5091146770 @default.
• W4387472583 hasBestOaLocation W43874725831 @default.
• W4387472583 hasConcept C104317684 @default.
• W4387472583 hasConcept C121608353 @default.
• W4387472583 hasConcept C126322002 @default.
• W4387472583 hasConcept C185592680 @default.
• W4387472583 hasConcept C2777695942 @default.
• W4387472583 hasConcept C2779013556 @default.
• W4387472583 hasConcept C2779251873 @default.
• W4387472583 hasConcept C2779704485 @default.
• W4387472583 hasConcept C2779742124 @default.
• W4387472583 hasConcept C31903555 @default.
• W4387472583 hasConcept C42062724 @default.
• W4387472583 hasConcept C526805850 @default.
• W4387472583 hasConcept C539455810 @default.
• W4387472583 hasConcept C55493867 @default.
• W4387472583 hasConcept C71924100 @default.
• W4387472583 hasConceptScore W4387472583C104317684 @default.
• W4387472583 hasConceptScore W4387472583C121608353 @default.
• W4387472583 hasConceptScore W4387472583C126322002 @default.
• W4387472583 hasConceptScore W4387472583C185592680 @default.
• W4387472583 hasConceptScore W4387472583C2777695942 @default.
• W4387472583 hasConceptScore W4387472583C2779013556 @default.
• W4387472583 hasConceptScore W4387472583C2779251873 @default.
• W4387472583 hasConceptScore W4387472583C2779704485 @default.
• W4387472583 hasConceptScore W4387472583C2779742124 @default.
• W4387472583 hasConceptScore W4387472583C31903555 @default.
• W4387472583 hasConceptScore W4387472583C42062724 @default.
• W4387472583 hasConceptScore W4387472583C526805850 @default.
• W4387472583 hasConceptScore W4387472583C539455810 @default.
• W4387472583 hasConceptScore W4387472583C55493867 @default.
• W4387472583 hasConceptScore W4387472583C71924100 @default.
• W4387472583 hasFunder F4320321001 @default.
• W4387472583 hasLocation W43874725831 @default.
• W4387472583 hasLocation W43874725832 @default.
• W4387472583 hasOpenAccess W4387472583 @default.
• W4387472583 hasPrimaryLocation W43874725831 @default.

• next