Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387472610> ?p ?o ?g. }
- W4387472610 abstract "To assess the feasibility of CEST-based creatine (Cr) mapping in brain at 3T using the guanidino (Guan) proton resonance.Wild type and knockout mice with guanidinoacetate N-methyltransferase deficiency and low Cr and phosphocreatine (PCr) concentrations in the brain were used to assign the Cr and protein-based arginine contributions to the GuanCEST signal at 2.0 ppm. To quantify the Cr proton exchange rate, two-step Bloch-McConnell fitting was used to fit the extracted CrCEST line-shape and multi-B1 Z-spectral data. The pH response of GuanCEST was simulated to demonstrate its potential for pH mapping.Brain Z-spectra of wild type and guanidinoacetate N-methyltransferase deficiency mice show a clear Guan proton peak at 2.0 ppm at 3T. The CrCEST signal contributes ∼23% to the GuanCEST signal at B1 = 0.8 μT, where a maximum CrCEST effect of 0.007 was detected. An exchange rate range of 200-300 s-1 was estimated for the Cr Guan protons. As revealed by the simulation, an elevated GuanCEST in the brain is observed when B1 is less than 0.4 μT at 3T, when intracellular pH reduces by 0.2. Conversely, the GuanCEST decreases when B1 is greater than 0.4 μT with the same pH drop.CrCEST mapping is possible at 3T, which has potential for detecting intracellular pH and Cr concentration in brain." @default.
- W4387472610 created "2023-10-11" @default.
- W4387472610 creator A5005095247 @default.
- W4387472610 creator A5012535211 @default.
- W4387472610 creator A5026285776 @default.
- W4387472610 creator A5033765540 @default.
- W4387472610 creator A5034911301 @default.
- W4387472610 creator A5040337172 @default.
- W4387472610 creator A5044682010 @default.
- W4387472610 creator A5064183380 @default.
- W4387472610 creator A5064715778 @default.
- W4387472610 creator A5078137445 @default.
- W4387472610 creator A5080669501 @default.
- W4387472610 creator A5083023771 @default.
- W4387472610 date "2023-10-09" @default.
- W4387472610 modified "2023-10-16" @default.
- W4387472610 title "Creatine mapping of the brain at <scp>3T</scp> by <scp>CEST MRI</scp>" @default.
- W4387472610 cites W1484173095 @default.
- W4387472610 cites W1500996517 @default.
- W4387472610 cites W1523464062 @default.
- W4387472610 cites W1777733060 @default.
- W4387472610 cites W183816881 @default.
- W4387472610 cites W1957534325 @default.
- W4387472610 cites W1975345407 @default.
- W4387472610 cites W1995721991 @default.
- W4387472610 cites W1995876376 @default.
- W4387472610 cites W2003126239 @default.
- W4387472610 cites W2004565920 @default.
- W4387472610 cites W2015128894 @default.
- W4387472610 cites W2017842468 @default.
- W4387472610 cites W2037921624 @default.
- W4387472610 cites W2042564460 @default.
- W4387472610 cites W2044288513 @default.
- W4387472610 cites W2059193992 @default.
- W4387472610 cites W2059784307 @default.
- W4387472610 cites W2062277520 @default.
- W4387472610 cites W2066520774 @default.
- W4387472610 cites W2074136578 @default.
- W4387472610 cites W2081742738 @default.
- W4387472610 cites W2098155836 @default.
- W4387472610 cites W2103632755 @default.
- W4387472610 cites W2125185978 @default.
- W4387472610 cites W2135788803 @default.
- W4387472610 cites W2145273520 @default.
- W4387472610 cites W2162234541 @default.
- W4387472610 cites W2169626075 @default.
- W4387472610 cites W2275107195 @default.
- W4387472610 cites W2293652050 @default.
- W4387472610 cites W2475108983 @default.
- W4387472610 cites W2520619769 @default.
- W4387472610 cites W2605468160 @default.
- W4387472610 cites W2621478401 @default.
- W4387472610 cites W2744561951 @default.
- W4387472610 cites W2760704924 @default.
- W4387472610 cites W2772071330 @default.
- W4387472610 cites W2793328357 @default.
- W4387472610 cites W2893927322 @default.
- W4387472610 cites W2911660488 @default.
- W4387472610 cites W2970659100 @default.
- W4387472610 cites W2980920895 @default.
- W4387472610 cites W3007880299 @default.
- W4387472610 cites W3038087131 @default.
- W4387472610 cites W3110810938 @default.
- W4387472610 cites W3142956847 @default.
- W4387472610 cites W3156703511 @default.
- W4387472610 cites W4200028130 @default.
- W4387472610 cites W4206421857 @default.
- W4387472610 cites W4211105878 @default.
- W4387472610 cites W4212777176 @default.
- W4387472610 cites W4251024555 @default.
- W4387472610 cites W4294643601 @default.
- W4387472610 cites W4295328826 @default.
- W4387472610 cites W4363646466 @default.
- W4387472610 doi "https://doi.org/10.1002/mrm.29876" @default.
- W4387472610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37814487" @default.
- W4387472610 hasPublicationYear "2023" @default.
- W4387472610 type Work @default.
- W4387472610 citedByCount "0" @default.
- W4387472610 crossrefType "journal-article" @default.
- W4387472610 hasAuthorship W4387472610A5005095247 @default.
- W4387472610 hasAuthorship W4387472610A5012535211 @default.
- W4387472610 hasAuthorship W4387472610A5026285776 @default.
- W4387472610 hasAuthorship W4387472610A5033765540 @default.
- W4387472610 hasAuthorship W4387472610A5034911301 @default.
- W4387472610 hasAuthorship W4387472610A5040337172 @default.
- W4387472610 hasAuthorship W4387472610A5044682010 @default.
- W4387472610 hasAuthorship W4387472610A5064183380 @default.
- W4387472610 hasAuthorship W4387472610A5064715778 @default.
- W4387472610 hasAuthorship W4387472610A5078137445 @default.
- W4387472610 hasAuthorship W4387472610A5080669501 @default.
- W4387472610 hasAuthorship W4387472610A5083023771 @default.
- W4387472610 hasConcept C113196181 @default.
- W4387472610 hasConcept C121332964 @default.
- W4387472610 hasConcept C134018914 @default.
- W4387472610 hasConcept C134897140 @default.
- W4387472610 hasConcept C185592680 @default.
- W4387472610 hasConcept C2777468819 @default.
- W4387472610 hasConcept C2778626300 @default.
- W4387472610 hasConcept C2779896295 @default.
- W4387472610 hasConcept C2986317502 @default.