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- W4387472823 abstract "Objective: This study was designed to explore KRT15 dysregulation and its correlation with clinical characteristics among ductal carcinoma in situ (DCIS), DCIS with microinvasion (DCIS-MI) and invasive breast cancer (IBC) patients. Methods: KRT15 from lesion samples of 50 DCIS patients, 48 DCIS-MI patients and 50 IBC patients was detected by immunohistochemistry. Results:KRT15 discriminated IBC patients from DCIS patients (area under the curve [AUC] = 0.895; 95% CI = 0.836-0.954) and DCIS-MI patients (AUC = 0.707; 95% CI = 0.606-0.808). In DCIS patients, KRT15 was negatively correlated with pathological grade (p = 0.015). In DCIS-MI patients, KRT15 was positively related to estrogen receptor positivity but negatively associated with Ki-67 (both p < 0.05). In IBC patients, KRT15 was negatively linked to HER2 positivity, histological grade, N stage and tumor node metastasis stage (all p < 0.05). Conclusion:KRT15 assessment may help with early breast cancer screening." @default.
- W4387472823 created "2023-10-11" @default.
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- W4387472823 date "2023-10-10" @default.
- W4387472823 modified "2023-10-13" @default.
- W4387472823 title "<i>KRT15</i> in early breast cancer screening and correlation with HER2 positivity, pathological grade and N stage" @default.
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- W4387472823 doi "https://doi.org/10.2217/bmm-2023-0130" @default.
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