FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387473219> ?p ?o ?g. }

• W4387473219 endingPage "16" @default.
• W4387473219 startingPage "1" @default.
• W4387473219 abstract "At the interface between genes and environment, epigenetic mechanisms, including DNA methylation and histone modification, regulate neurogenic processes such as differentiation, proliferation, and maturation of neural stem cells. However, these mechanisms are altered in Alzheimer's disease (AD), a neurodegenerative condition that mainly affects older adults. Since epigenetic mechanisms are known to be reversible, a number of molecules from natural sources are being studied as epigenetic regulators in AD. Recently, in vitro and in silico studies have shown that C. subedentata and its alkaloids modulated neurotoxicity. However, studies exploring the epigenetic activity of these alkaloids are limited. We conducted a set of bioassays to evaluate neuronal differentiation and the sensitivity of undifferentiated SH-SY5 cells against a neurotoxic stimulus. In addition, we analyzed the methylation profiles in genes such as APP, PSI, and BACE1 due to their role in amyloid processing. Docking and molecular dynamic analysis were used to explore the effect exerted by C. subedentata alkaloids on the regulation of histone deacetylases (HDAC2, HDAC3 and HDAC7). The results demonstrated that C. subedentata and galantamine induce neuronal differentiation and protect the undifferentiated SH-SY5Y cells against Aβ(1-42)-induced neurotoxicity. The methylation profiles of the studied genes show no statistically significant differences between C. subedentata, galantamine. However, these findings should be interpreted with caution, since small changes in methylation promoters in the brain could not be easily detected. Results from in silico approaches describe for the first time the potential promissing epigenetic effects of galantamine by regulating HDAC3 and HDAC7 modification.Communicated by Ramaswamy H. Sarma." @default.
• W4387473219 created "2023-10-11" @default.
• W4387473219 creator A5032272315 @default.
• W4387473219 creator A5035842049 @default.
• W4387473219 creator A5056438560 @default.
• W4387473219 creator A5087311194 @default.
• W4387473219 date "2023-10-10" @default.
• W4387473219 modified "2023-10-12" @default.
• W4387473219 title "Epigenetic regulation exerted by <i>Caliphruria subedentata</i> and galantamine: an <i>in vitro</i> and <i>in silico</i> approach for mimic Alzheimer’s disease" @default.
• W4387473219 cites W1111034816 @default.
• W4387473219 cites W1951470991 @default.
• W4387473219 cites W1964095432 @default.
• W4387473219 cites W1967434207 @default.
• W4387473219 cites W1970985465 @default.
• W4387473219 cites W1973577140 @default.
• W4387473219 cites W1981769964 @default.
• W4387473219 cites W2013547494 @default.
• W4387473219 cites W2019699796 @default.
• W4387473219 cites W2019845642 @default.
• W4387473219 cites W2020089910 @default.
• W4387473219 cites W2021289158 @default.
• W4387473219 cites W2023404623 @default.
• W4387473219 cites W2025239975 @default.
• W4387473219 cites W2028046413 @default.
• W4387473219 cites W2028597345 @default.
• W4387473219 cites W2033902375 @default.
• W4387473219 cites W2044172327 @default.
• W4387473219 cites W2045797697 @default.
• W4387473219 cites W2046043184 @default.
• W4387473219 cites W2048061357 @default.
• W4387473219 cites W2050456292 @default.
• W4387473219 cites W2070753604 @default.
• W4387473219 cites W2077005770 @default.
• W4387473219 cites W2080066067 @default.
• W4387473219 cites W2082467262 @default.
• W4387473219 cites W2083776548 @default.
• W4387473219 cites W2090760765 @default.
• W4387473219 cites W2093057302 @default.
• W4387473219 cites W2098633756 @default.
• W4387473219 cites W2102177106 @default.
• W4387473219 cites W2113056756 @default.
• W4387473219 cites W2129062017 @default.
• W4387473219 cites W2130479394 @default.
• W4387473219 cites W2130541969 @default.
• W4387473219 cites W2137201812 @default.
• W4387473219 cites W2144463858 @default.
• W4387473219 cites W2148239264 @default.
• W4387473219 cites W2161778428 @default.
• W4387473219 cites W2171268876 @default.
• W4387473219 cites W2177317049 @default.
• W4387473219 cites W2214652952 @default.
• W4387473219 cites W2308389231 @default.
• W4387473219 cites W2339751190 @default.
• W4387473219 cites W2477382531 @default.
• W4387473219 cites W2543598768 @default.
• W4387473219 cites W2555870966 @default.
• W4387473219 cites W2563433138 @default.
• W4387473219 cites W2612556895 @default.
• W4387473219 cites W2767750422 @default.
• W4387473219 cites W2794051327 @default.
• W4387473219 cites W2802245755 @default.
• W4387473219 cites W2806432410 @default.
• W4387473219 cites W2895172777 @default.
• W4387473219 cites W2898405818 @default.
• W4387473219 cites W2900379577 @default.
• W4387473219 cites W2901793375 @default.
• W4387473219 cites W2929231739 @default.
• W4387473219 cites W2933970220 @default.
• W4387473219 cites W2943149722 @default.
• W4387473219 cites W2984827653 @default.
• W4387473219 cites W3019541266 @default.
• W4387473219 cites W3041121325 @default.
• W4387473219 cites W3094047588 @default.
• W4387473219 cites W3094448439 @default.
• W4387473219 cites W3096847991 @default.
• W4387473219 cites W4210776021 @default.
• W4387473219 cites W4382181708 @default.
• W4387473219 doi "https://doi.org/10.1080/07391102.2023.2261034" @default.
• W4387473219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37814967" @default.
• W4387473219 hasPublicationYear "2023" @default.
• W4387473219 type Work @default.
• W4387473219 citedByCount "0" @default.
• W4387473219 crossrefType "journal-article" @default.
• W4387473219 hasAuthorship W4387473219A5032272315 @default.
• W4387473219 hasAuthorship W4387473219A5035842049 @default.
• W4387473219 hasAuthorship W4387473219A5056438560 @default.
• W4387473219 hasAuthorship W4387473219A5087311194 @default.
• W4387473219 hasConcept C104317684 @default.
• W4387473219 hasConcept C126322002 @default.
• W4387473219 hasConcept C150194340 @default.
• W4387473219 hasConcept C190727270 @default.
• W4387473219 hasConcept C2775905019 @default.
• W4387473219 hasConcept C2779056891 @default.
• W4387473219 hasConcept C2779134260 @default.
• W4387473219 hasConcept C2779483572 @default.
• W4387473219 hasConcept C2780904820 @default.
• W4387473219 hasConcept C33288867 @default.
• W4387473219 hasConcept C41091548 @default.

• next