Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387473340> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4387473340 abstract "Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive (MDA5+) dermatomyositis patients exhibit a variety of clinical features. We therefore investigated whether patterns of B cell epitope recognition are linked to the clinical course of MDA5+ dermatomyositis.Our cross-sectional study used ELISA-based methods to determine the relationship between antibody recognition of overlapping 155 amino acid MDA5 subfragments and clinical features of 24 MDA5+ myositis patients. Correlations between clinical features and standardized anti-MDA5 subfragment antibody titers were assessed via Spearman's rank correlation coefficients.Twenty-four MDA5+ patients submitted serum samples within a median of 0 (interquartile range, 0-74) days from the initial clinic visit. In addition to typical dermatomyositis rashes, these patients exhibited muscle symptoms (n = 11), vascular dysfunction (n = 9), and interstitial lung disease (ILD) (n = 16). Female patients exhibited higher titers of antibodies recognizing fragment H (aa 905-1026) compared to male patients. Muscle involvement was associated with higher levels of anti-fragment F (aa 646-801) antibody. Conversely, patients with vascular abnormalities had higher anti-fragment B (aa 130-284) and E (aa 517-671) antibody titers than those without vascular dysfunction. Four patients died due to ILD progression and showed higher anti-fragment A (aa 1-155) antibody titers than the other 20 patients. Differences in the ratio of anti-fragment to anti-full length MDA5 antibody titers were found for sex (H: anti-MDA5) and vascular dysfunction (anti-fragment B, E: anti-MDA5).Various clinical features of MDA5+ dermatomyositis correlated with levels of antibodies targeting selected subfragments of this autoantigen, providing a link between fragment-specific immune responses and disease course." @default.
- W4387473340 created "2023-10-11" @default.
- W4387473340 creator A5002287600 @default.
- W4387473340 creator A5006196613 @default.
- W4387473340 creator A5006757559 @default.
- W4387473340 creator A5021263684 @default.
- W4387473340 creator A5021312163 @default.
- W4387473340 creator A5026557784 @default.
- W4387473340 creator A5042076633 @default.
- W4387473340 creator A5072041025 @default.
- W4387473340 creator A5087131860 @default.
- W4387473340 date "2023-10-10" @default.
- W4387473340 modified "2023-10-16" @default.
- W4387473340 title "Correlation between B cell epitope profile and clinical features of anti-MDA5 antibody-positive dermatomyositis" @default.
- W4387473340 doi "https://doi.org/10.1093/rheumatology/kead550" @default.
- W4387473340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37815819" @default.
- W4387473340 hasPublicationYear "2023" @default.
- W4387473340 type Work @default.
- W4387473340 citedByCount "0" @default.
- W4387473340 crossrefType "journal-article" @default.
- W4387473340 hasAuthorship W4387473340A5002287600 @default.
- W4387473340 hasAuthorship W4387473340A5006196613 @default.
- W4387473340 hasAuthorship W4387473340A5006757559 @default.
- W4387473340 hasAuthorship W4387473340A5021263684 @default.
- W4387473340 hasAuthorship W4387473340A5021312163 @default.
- W4387473340 hasAuthorship W4387473340A5026557784 @default.
- W4387473340 hasAuthorship W4387473340A5042076633 @default.
- W4387473340 hasAuthorship W4387473340A5072041025 @default.
- W4387473340 hasAuthorship W4387473340A5087131860 @default.
- W4387473340 hasConcept C126322002 @default.
- W4387473340 hasConcept C142724271 @default.
- W4387473340 hasConcept C159654299 @default.
- W4387473340 hasConcept C203014093 @default.
- W4387473340 hasConcept C22889606 @default.
- W4387473340 hasConcept C2777543607 @default.
- W4387473340 hasConcept C2777714996 @default.
- W4387473340 hasConcept C2778751314 @default.
- W4387473340 hasConcept C2781232998 @default.
- W4387473340 hasConcept C32611913 @default.
- W4387473340 hasConcept C71924100 @default.
- W4387473340 hasConcept C90924648 @default.
- W4387473340 hasConceptScore W4387473340C126322002 @default.
- W4387473340 hasConceptScore W4387473340C142724271 @default.
- W4387473340 hasConceptScore W4387473340C159654299 @default.
- W4387473340 hasConceptScore W4387473340C203014093 @default.
- W4387473340 hasConceptScore W4387473340C22889606 @default.
- W4387473340 hasConceptScore W4387473340C2777543607 @default.
- W4387473340 hasConceptScore W4387473340C2777714996 @default.
- W4387473340 hasConceptScore W4387473340C2778751314 @default.
- W4387473340 hasConceptScore W4387473340C2781232998 @default.
- W4387473340 hasConceptScore W4387473340C32611913 @default.
- W4387473340 hasConceptScore W4387473340C71924100 @default.
- W4387473340 hasConceptScore W4387473340C90924648 @default.
- W4387473340 hasLocation W43874733401 @default.
- W4387473340 hasLocation W43874733402 @default.
- W4387473340 hasOpenAccess W4387473340 @default.
- W4387473340 hasPrimaryLocation W43874733401 @default.
- W4387473340 hasRelatedWork W1973700516 @default.
- W4387473340 hasRelatedWork W1986656507 @default.
- W4387473340 hasRelatedWork W2008990182 @default.
- W4387473340 hasRelatedWork W2032036369 @default.
- W4387473340 hasRelatedWork W2146236038 @default.
- W4387473340 hasRelatedWork W2313160977 @default.
- W4387473340 hasRelatedWork W2386432210 @default.
- W4387473340 hasRelatedWork W2954782608 @default.
- W4387473340 hasRelatedWork W3030133063 @default.
- W4387473340 hasRelatedWork W4245342515 @default.
- W4387473340 isParatext "false" @default.
- W4387473340 isRetracted "false" @default.
- W4387473340 workType "article" @default.