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• W4387473410 abstract "A series of tetrahydroisoquinoline derivatives were prepared and their antitumor activity was studied against several human carcinoma cell lines, including Ketr3, BEL-7402, BGC-823, KB, HCT-8, MCF-7, HeLa, A2780, A549, and HT-1080. Compound 20, an analog of phthalascidin 650, exhibited good broad-spectrum antitumor activity in vitro. However, compounds 19 and 21, in which the side chains at C-22 are simplified, showed no obvious antitumor activity, indicating that the C-22 side chain of this type of compound has a greater impact on its activity. The difference in the in vivo activity between compound 20 and phthalascidin 650 also shows a significant effect of the substituents on the skeleton structure on the in vivo activity." @default.
• W4387473410 created "2023-10-11" @default.
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• W4387473410 date "2023-10-09" @default.
• W4387473410 modified "2023-10-16" @default.
• W4387473410 title "Design, synthesis, and biological evaluation of simplified tetrahydroisoquinoline analogs" @default.
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• W4387473410 doi "https://doi.org/10.1002/ardp.202300453" @default.
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