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• W4387473483 abstract "ABSTRACTSome post-licensure studies have shown a potential increased risk of intussusception following vaccination with rotavirus vaccines. This is the first study that aimed to assess the incidence and risk of intussusception within 90 days after vaccination with RotaTeq in Chinese infants. A population-based birth cohort from November 27th 2018 to June 30th 2021 included all newborns in Ningbo city. The records of intussusception were identified through the ICD-10 code K56.1 or Chinese keywords Chang Tao from all hospital discharge records. Each episode was confirmed in line with the Brighton criteria, and only Brighton level 1 cases were included. The association of RotaTeq vaccination and intussusception was evaluated using the Poisson regression. A total of 108,405 eligible subjects from birth cohort were eligible, with 52.30% males. Among them, 26, 847 (24.77%) infants received at least one dose of RotaTeq, and 95.52% of them were fully vaccinated, with 76, 934 doses in total. After adjudication, none of the cases occurred post first, or second dose, the cumulative number of cases that occurred 1-7, 1-14, 1-21, 1-42, and 1-90 days post third dose was 0, 1, 1, 3 and 7, respectively. Adjusting for age, sex, birth year, birth season and location, the incidence rate ratio (IRR) of intussusception after RotaTeq vaccination was 0.90 (90% two-sided CI: 0.46, 1.75). Increasing age and male gender were associated with higher risk of intussusception. In summary, no increased risk of IS was observed following 3 months of RotaTeq vaccination in this study." @default.
• W4387473483 created "2023-10-11" @default.
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• W4387473483 date "2023-10-10" @default.
• W4387473483 modified "2023-10-16" @default.
• W4387473483 title "No increased Risk of Intussusception after Pentavalent Rotavirus Vaccination in China: a retrospective birth cohort using electronic health records of Ningbo city" @default.
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• W4387473483 doi "https://doi.org/10.1080/22221751.2023.2270062" @default.
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