FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387476723> ?p ?o ?g. }

• W4387476723 endingPage "S111" @default.
• W4387476723 startingPage "S110" @default.
• W4387476723 abstract "It is known that diagnostic labels of complex psychiatric disorders, like attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD), may not be distinctive at the level of their etiologies. Understanding the biology underlying psychiatric disorders is challenging because of phenotypic and genetic heterogeneity and by frequent comorbidities that also extend to somatic conditions, e.g. diabetes mellitus type 2 and obesity that share genetic risk. Looking beyond the labels of psychiatric disorders with disorder-like traits has shown to be fruitful for genetic analyses. Therefore, we aim to explore the continuum of psychiatric symptoms in combination with insulin-related somatic measures to explore the existence of shared genetic architectures. We hypothesize that this ‘genetics-first’ approach can identify potential biological profiles of subgroups within psychiatry. For our approach we utilized publicly available summary statistics of the largest genome-wide association studies (GWASs) of ADHD, ASD and OCD symptoms and insulin-related measures available at the time of performing our analyses. For exploratory analyses, we prioritized insulin-related somatic traits that are genetically correlated to ADHD, ASD or OCD. Thereafter we applied multivariate genomic structural equation modeling (genomicSEM) to investigate latent genetic factors underlying GWASs of ADHD symptoms (n=17,666), OCD symptom and cases (n= 17,992) and social behavior linked to ASD (n=342,461) with five insulin-related traits (body mass index (BMI), fasting glucose, fasting insulin, glycated hemoglobin, and homeostatic model assessment for insulin resistance (HOMA-IR), n=98,210-697,734). Using exploratory and confirmatory factor analyses we explored the best fit to our data. A three-factor model fitted our data the best (AIC=57, CFI=0.99, SRMR=0.068). The first factor was loaded by solely insulin-related traits (BMI, fasting insulin and HOMA-IR). The second latent factor included ADHD symptom scores together with BMI, fasting glucose and glycated hemoglobin. The third factor included OCD symptom and case scores loaded together with glycated hemoglobin. At the moment we are running a multivariate GWAS to explore genetic variants underlying these factors. Moreover, we will apply gene-wide and gene-set analyses to identify relevant genes for these clusters and interpret GWAS outcomes of our results. Our findings show that latent genetic factors exist reflecting shared liabilities underlying psychiatric traits with insulin-related measures. The observed factors driven by both psychiatric traits and insulin-related traits suggest potential novel subgroups in psychiatric disorders such as ADHD and OCD. The study provides groundwork to further conduct in depth analyses of the role of insulin-related traits in psychiatry. Furthermore, this project suggests that biologically informed subgroups might capture the heterogeneity of psychiatric disorders and allow more personalized treatment approaches." @default.
• W4387476723 created "2023-10-11" @default.
• W4387476723 creator A5002640181 @default.
• W4387476723 creator A5022100095 @default.
• W4387476723 creator A5030442312 @default.
• W4387476723 creator A5033457104 @default.
• W4387476723 creator A5082791385 @default.
• W4387476723 creator A5088925734 @default.
• W4387476723 date "2023-10-01" @default.
• W4387476723 modified "2023-10-16" @default.
• W4387476723 title "W12. LOOKING BEYOND LABELS: DEFINING DIMENSIONAL PSYCHIATRIC SYMPTOM CLUSTERS WITH INSULIN-RELATED SOMATIC MEASURES BASED ON LARGE POPULATION-BASED GENETIC DATASETS" @default.
• W4387476723 doi "https://doi.org/10.1016/j.euroneuro.2023.08.204" @default.
• W4387476723 hasPublicationYear "2023" @default.
• W4387476723 type Work @default.
• W4387476723 citedByCount "0" @default.
• W4387476723 crossrefType "journal-article" @default.
• W4387476723 hasAuthorship W4387476723A5002640181 @default.
• W4387476723 hasAuthorship W4387476723A5022100095 @default.
• W4387476723 hasAuthorship W4387476723A5030442312 @default.
• W4387476723 hasAuthorship W4387476723A5033457104 @default.
• W4387476723 hasAuthorship W4387476723A5082791385 @default.
• W4387476723 hasAuthorship W4387476723A5088925734 @default.
• W4387476723 hasConcept C104317684 @default.
• W4387476723 hasConcept C106208931 @default.
• W4387476723 hasConcept C118552586 @default.
• W4387476723 hasConcept C126322002 @default.
• W4387476723 hasConcept C134018914 @default.
• W4387476723 hasConcept C135763542 @default.
• W4387476723 hasConcept C153209595 @default.
• W4387476723 hasConcept C15744967 @default.
• W4387476723 hasConcept C205778803 @default.
• W4387476723 hasConcept C2777180221 @default.
• W4387476723 hasConcept C2777391703 @default.
• W4387476723 hasConcept C2777538456 @default.
• W4387476723 hasConcept C2778538070 @default.
• W4387476723 hasConcept C2779159551 @default.
• W4387476723 hasConcept C2779306644 @default.
• W4387476723 hasConcept C2780783007 @default.
• W4387476723 hasConcept C2908647359 @default.
• W4387476723 hasConcept C54355233 @default.
• W4387476723 hasConcept C555293320 @default.
• W4387476723 hasConcept C70410870 @default.
• W4387476723 hasConcept C71924100 @default.
• W4387476723 hasConcept C86803240 @default.
• W4387476723 hasConcept C99454951 @default.
• W4387476723 hasConceptScore W4387476723C104317684 @default.
• W4387476723 hasConceptScore W4387476723C106208931 @default.
• W4387476723 hasConceptScore W4387476723C118552586 @default.
• W4387476723 hasConceptScore W4387476723C126322002 @default.
• W4387476723 hasConceptScore W4387476723C134018914 @default.
• W4387476723 hasConceptScore W4387476723C135763542 @default.
• W4387476723 hasConceptScore W4387476723C153209595 @default.
• W4387476723 hasConceptScore W4387476723C15744967 @default.
• W4387476723 hasConceptScore W4387476723C205778803 @default.
• W4387476723 hasConceptScore W4387476723C2777180221 @default.
• W4387476723 hasConceptScore W4387476723C2777391703 @default.
• W4387476723 hasConceptScore W4387476723C2777538456 @default.
• W4387476723 hasConceptScore W4387476723C2778538070 @default.
• W4387476723 hasConceptScore W4387476723C2779159551 @default.
• W4387476723 hasConceptScore W4387476723C2779306644 @default.
• W4387476723 hasConceptScore W4387476723C2780783007 @default.
• W4387476723 hasConceptScore W4387476723C2908647359 @default.
• W4387476723 hasConceptScore W4387476723C54355233 @default.
• W4387476723 hasConceptScore W4387476723C555293320 @default.
• W4387476723 hasConceptScore W4387476723C70410870 @default.
• W4387476723 hasConceptScore W4387476723C71924100 @default.
• W4387476723 hasConceptScore W4387476723C86803240 @default.
• W4387476723 hasConceptScore W4387476723C99454951 @default.
• W4387476723 hasLocation W43874767231 @default.
• W4387476723 hasOpenAccess W4387476723 @default.
• W4387476723 hasPrimaryLocation W43874767231 @default.
• W4387476723 hasRelatedWork W1972310289 @default.
• W4387476723 hasRelatedWork W1978188354 @default.
• W4387476723 hasRelatedWork W2002142585 @default.
• W4387476723 hasRelatedWork W2125404607 @default.
• W4387476723 hasRelatedWork W2155091457 @default.
• W4387476723 hasRelatedWork W2157868280 @default.
• W4387476723 hasRelatedWork W2765738011 @default.
• W4387476723 hasRelatedWork W2795699014 @default.
• W4387476723 hasRelatedWork W3141224953 @default.
• W4387476723 hasRelatedWork W4387318495 @default.
• W4387476723 hasVolume "75" @default.
• W4387476723 isParatext "false" @default.
• W4387476723 isRetracted "false" @default.
• W4387476723 workType "article" @default.