FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387476761> ?p ?o ?g. }

• W4387476761 endingPage "S90" @default.
• W4387476761 startingPage "S89" @default.
• W4387476761 abstract "Patients with schizophrenia have substantial comorbidity contributing to reduced life expectancy of 10-20 years. In fact, 64% of patients have more than one comorbidity (multi-morbidity) increasing mortality further. Identifying which comorbidities might be modifiable could improve rates of premature mortality in this population. We hypothesize that conditions that frequently co-occur but lack shared genetic risk with schizophrenia are more likely to be products of treatment, behavior, or environmental factors and therefore potentially modifiable. To test this hypothesis, phenome-wide comorbidity from electronic health records (EHR) was estimated from logistic regressions of pairwise comparisons of all phecodes with demographic and utilization as covariates. Comorbidity was calculated in 250,000 randomly selected patients separately in two independent health care systems (Vanderbilt University Medical Center, VUMC; Mass General Brigham, MGB) and then combined through weighted average. Schizophrenia polygenic risk scores (PRS) were calculated within each institute's genotyped datasets (∼65k VUMC; ∼25K MGB) and then combined through meta-analysis. A TOST test of equivalence was used to statistically identify which phenotypic associations had well powered absence of association with schizophrenia PRS and then were summarized across sites with Fisher's method for combining p-values. Comorbidity with schizophrenia was significantly correlated across institutions (r = 0.85) and consistent with prior literature. After multiple test correction, there were 77 significant phecodes comorbid with schizophrenia. Overall, comorbidity and PRS associations were highly correlated (r = 0.55, p = 1.29 × 10-118), however, 36 of the EHR identified comorbidities had significantly equivalent schizophrenia PRS distributions between cases and controls. Fifteen of these lacked any PRS association and were enriched for phenotypes known to be side effects of antipsychotic medications (e.g., “movement disorders”, “convulsions”, “tachycardia”) or other schizophrenia related factors such as from smoking (“bronchitis”) or reduced hygiene (e.g., “diseases of the nail”) highlighting the validity of this approach. Other phenotypes implicated by this approach where the contribution from shared common genetic risk with schizophrenia was minimal included tobacco use disorder, diabetes, and dementia. This work demonstrates the consistency and robustness of EHR-based schizophrenia comorbidities across independent institutions and with the existing literature. We present an approach that intersects EHR-based comorbidities with PRS-based genetic associations to identify comorbidities with an absence of shared genetic risk. Thus, indicating other causes that might be more modifiable such as behavior, treatment, or environment and identifying where further study of causal pathways could improve outcomes for patients. Overall, this work provides a path to better understanding comorbidities which might be more easily modified to improve outcomes." @default.
• W4387476761 created "2023-10-11" @default.
• W4387476761 creator A5006240422 @default.
• W4387476761 creator A5016502031 @default.
• W4387476761 creator A5019245881 @default.
• W4387476761 creator A5051645560 @default.
• W4387476761 creator A5059089739 @default.
• W4387476761 creator A5061001433 @default.
• W4387476761 creator A5062987573 @default.
• W4387476761 creator A5071263804 @default.
• W4387476761 creator A5091656030 @default.
• W4387476761 creator A5092088160 @default.
• W4387476761 date "2023-10-01" @default.
• W4387476761 modified "2023-10-16" @default.
• W4387476761 title "63. IDENTIFYING MODIFIABLE COMORBIDITIES OF SCHIZOPHRENIA BY INTEGRATING ELECTRONIC HEALTH RECORDS AND POLYGENIC RISK" @default.
• W4387476761 doi "https://doi.org/10.1016/j.euroneuro.2023.08.168" @default.
• W4387476761 hasPublicationYear "2023" @default.
• W4387476761 type Work @default.
• W4387476761 citedByCount "0" @default.
• W4387476761 crossrefType "journal-article" @default.
• W4387476761 hasAuthorship W4387476761A5006240422 @default.
• W4387476761 hasAuthorship W4387476761A5016502031 @default.
• W4387476761 hasAuthorship W4387476761A5019245881 @default.
• W4387476761 hasAuthorship W4387476761A5051645560 @default.
• W4387476761 hasAuthorship W4387476761A5059089739 @default.
• W4387476761 hasAuthorship W4387476761A5061001433 @default.
• W4387476761 hasAuthorship W4387476761A5062987573 @default.
• W4387476761 hasAuthorship W4387476761A5071263804 @default.
• W4387476761 hasAuthorship W4387476761A5091656030 @default.
• W4387476761 hasAuthorship W4387476761A5092088160 @default.
• W4387476761 hasConcept C118552586 @default.
• W4387476761 hasConcept C2776412080 @default.
• W4387476761 hasConcept C2779159551 @default.
• W4387476761 hasConcept C2908647359 @default.
• W4387476761 hasConcept C70410870 @default.
• W4387476761 hasConcept C71924100 @default.
• W4387476761 hasConcept C99454951 @default.
• W4387476761 hasConceptScore W4387476761C118552586 @default.
• W4387476761 hasConceptScore W4387476761C2776412080 @default.
• W4387476761 hasConceptScore W4387476761C2779159551 @default.
• W4387476761 hasConceptScore W4387476761C2908647359 @default.
• W4387476761 hasConceptScore W4387476761C70410870 @default.
• W4387476761 hasConceptScore W4387476761C71924100 @default.
• W4387476761 hasConceptScore W4387476761C99454951 @default.
• W4387476761 hasLocation W43874767611 @default.
• W4387476761 hasOpenAccess W4387476761 @default.
• W4387476761 hasPrimaryLocation W43874767611 @default.
• W4387476761 hasRelatedWork W1978188354 @default.
• W4387476761 hasRelatedWork W2002142585 @default.
• W4387476761 hasRelatedWork W2143494072 @default.
• W4387476761 hasRelatedWork W2155091457 @default.
• W4387476761 hasRelatedWork W2157868280 @default.
• W4387476761 hasRelatedWork W2765738011 @default.
• W4387476761 hasRelatedWork W2795699014 @default.
• W4387476761 hasRelatedWork W3141224953 @default.
• W4387476761 hasRelatedWork W4211108626 @default.
• W4387476761 hasRelatedWork W4387318495 @default.
• W4387476761 hasVolume "75" @default.
• W4387476761 isParatext "false" @default.
• W4387476761 isRetracted "false" @default.
• W4387476761 workType "article" @default.