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- W4387477772 endingPage "708" @default.
- W4387477772 startingPage "688" @default.
- W4387477772 abstract "As the most common and aggressive type of primary brain tumor in adults, glioblastoma is estimated to end over 10,000 lives each year in the United States alone. Stand treatment for glioblastoma, including surgery followed by radiotherapy and chemotherapy (i.e., Temozolomide), has been largely unchanged since early 2000. Cancer immunotherapy has significantly shifted the paradigm of cancer management in the past decade with various degrees of success in treating many hematopoietic cancers and some solid tumors, such as melanoma and non-small cell lung cancer (NSCLC). However, little progress has been made in the field of neuro-oncology, especially in the application of immunotherapy to glioblastoma treatment. In this review, we attempted to summarize the common drug resistance mechanisms in glioblastoma from Temozolomide to immunotherapy. Our intent is not to repeat the well-known difficulty in the area of neuro-oncology, such as the blood-brain barrier, but to provide some fresh insights into the molecular mechanisms responsible for resistance by summarizing some of the most recent literature. Through this review, we also hope to share some new ideas for improving the immunotherapy outcome of glioblastoma treatment." @default.
- W4387477772 created "2023-10-11" @default.
- W4387477772 creator A5014830926 @default.
- W4387477772 creator A5017817940 @default.
- W4387477772 creator A5073932768 @default.
- W4387477772 date "2023-10-11" @default.
- W4387477772 modified "2023-10-16" @default.
- W4387477772 title "Drug resistance in glioblastoma: from chemo- to immunotherapy" @default.
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