Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387492110> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4387492110 abstract "Hepatocellular carcinoma (HCC) is closely associated with inflammation and immune modulation, and combined chemotherapy with other strategies is under extensive investigation to achieve better efficacy. HCC is accompanied by zinc deficiency. This study aims to understand how zinc could affect macrophage function and its application for HCC therapy.Zn2+ and the zinc transporter 1 (ZNT1, SLC30A1) were markedly reduced in intrahepatic macrophages from HCC patients and mouse liver tumors. Lower ZNT1 expression was associated with higher IL-6 production and shorter survival time in HCC patients. Critically, ZNT1 regulated endosomal Zn2+ levels for endocytosis of TLR4 and PD-L1, thereby decreasing macrophage-induced inflammation and immunosuppression to protect from liver tumors. Myeloid-specific deletion of ZNT1 in mice increased chronic inflammation, liver fibrosis, tumor numbers, and size. Notably, zinc supplementation could reduce inflammation and surface PD-L1 expression in macrophages with the increased CD8+ T cell cytotoxicity, which synergized the anti-tumor efficacy of Sorafenib/Lenvatinib.Our study proposes a new concept that ZNT1 and zinc regulate endosome endocytosis to maintain surface receptors and zinc supplements might be synergized with chemotherapy to treat inflammation-associated tumors, especially those containing PD-L1+ myeloid cells." @default.
- W4387492110 created "2023-10-11" @default.
- W4387492110 creator A5003040978 @default.
- W4387492110 creator A5005247857 @default.
- W4387492110 creator A5011835067 @default.
- W4387492110 creator A5021073603 @default.
- W4387492110 creator A5021293109 @default.
- W4387492110 creator A5022098030 @default.
- W4387492110 creator A5026394330 @default.
- W4387492110 creator A5034366062 @default.
- W4387492110 creator A5036384020 @default.
- W4387492110 creator A5037472498 @default.
- W4387492110 creator A5040893295 @default.
- W4387492110 creator A5040911969 @default.
- W4387492110 creator A5049475098 @default.
- W4387492110 creator A5053447705 @default.
- W4387492110 creator A5069413008 @default.
- W4387492110 creator A5076305978 @default.
- W4387492110 creator A5079336998 @default.
- W4387492110 creator A5085898704 @default.
- W4387492110 creator A5089205578 @default.
- W4387492110 creator A5091669896 @default.
- W4387492110 date "2023-10-09" @default.
- W4387492110 modified "2023-10-12" @default.
- W4387492110 title "ZNT1 and Zn2+ control TLR4 and PD-L1 endocytosis in macrophage to improve chemotherapy efficacy against liver tumor" @default.
- W4387492110 doi "https://doi.org/10.1097/hep.0000000000000629" @default.
- W4387492110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37816045" @default.
- W4387492110 hasPublicationYear "2023" @default.
- W4387492110 type Work @default.
- W4387492110 citedByCount "0" @default.
- W4387492110 crossrefType "journal-article" @default.
- W4387492110 hasAuthorship W4387492110A5003040978 @default.
- W4387492110 hasAuthorship W4387492110A5005247857 @default.
- W4387492110 hasAuthorship W4387492110A5011835067 @default.
- W4387492110 hasAuthorship W4387492110A5021073603 @default.
- W4387492110 hasAuthorship W4387492110A5021293109 @default.
- W4387492110 hasAuthorship W4387492110A5022098030 @default.
- W4387492110 hasAuthorship W4387492110A5026394330 @default.
- W4387492110 hasAuthorship W4387492110A5034366062 @default.
- W4387492110 hasAuthorship W4387492110A5036384020 @default.
- W4387492110 hasAuthorship W4387492110A5037472498 @default.
- W4387492110 hasAuthorship W4387492110A5040893295 @default.
- W4387492110 hasAuthorship W4387492110A5040911969 @default.
- W4387492110 hasAuthorship W4387492110A5049475098 @default.
- W4387492110 hasAuthorship W4387492110A5053447705 @default.
- W4387492110 hasAuthorship W4387492110A5069413008 @default.
- W4387492110 hasAuthorship W4387492110A5076305978 @default.
- W4387492110 hasAuthorship W4387492110A5079336998 @default.
- W4387492110 hasAuthorship W4387492110A5085898704 @default.
- W4387492110 hasAuthorship W4387492110A5089205578 @default.
- W4387492110 hasAuthorship W4387492110A5091669896 @default.
- W4387492110 hasConcept C126322002 @default.
- W4387492110 hasConcept C170493617 @default.
- W4387492110 hasConcept C202751555 @default.
- W4387492110 hasConcept C203014093 @default.
- W4387492110 hasConcept C2776070231 @default.
- W4387492110 hasConcept C2776914184 @default.
- W4387492110 hasConcept C2777701055 @default.
- W4387492110 hasConcept C2778019345 @default.
- W4387492110 hasConcept C2779244956 @default.
- W4387492110 hasConcept C28005876 @default.
- W4387492110 hasConcept C502942594 @default.
- W4387492110 hasConcept C55493867 @default.
- W4387492110 hasConcept C71924100 @default.
- W4387492110 hasConcept C86803240 @default.
- W4387492110 hasConcept C8891405 @default.
- W4387492110 hasConceptScore W4387492110C126322002 @default.
- W4387492110 hasConceptScore W4387492110C170493617 @default.
- W4387492110 hasConceptScore W4387492110C202751555 @default.
- W4387492110 hasConceptScore W4387492110C203014093 @default.
- W4387492110 hasConceptScore W4387492110C2776070231 @default.
- W4387492110 hasConceptScore W4387492110C2776914184 @default.
- W4387492110 hasConceptScore W4387492110C2777701055 @default.
- W4387492110 hasConceptScore W4387492110C2778019345 @default.
- W4387492110 hasConceptScore W4387492110C2779244956 @default.
- W4387492110 hasConceptScore W4387492110C28005876 @default.
- W4387492110 hasConceptScore W4387492110C502942594 @default.
- W4387492110 hasConceptScore W4387492110C55493867 @default.
- W4387492110 hasConceptScore W4387492110C71924100 @default.
- W4387492110 hasConceptScore W4387492110C86803240 @default.
- W4387492110 hasConceptScore W4387492110C8891405 @default.
- W4387492110 hasLocation W43874921101 @default.
- W4387492110 hasLocation W43874921102 @default.
- W4387492110 hasOpenAccess W4387492110 @default.
- W4387492110 hasPrimaryLocation W43874921101 @default.
- W4387492110 hasRelatedWork W1984850107 @default.
- W4387492110 hasRelatedWork W1989945146 @default.
- W4387492110 hasRelatedWork W2034791541 @default.
- W4387492110 hasRelatedWork W2045202254 @default.
- W4387492110 hasRelatedWork W2046128749 @default.
- W4387492110 hasRelatedWork W2047247630 @default.
- W4387492110 hasRelatedWork W2058869315 @default.
- W4387492110 hasRelatedWork W2398374228 @default.
- W4387492110 hasRelatedWork W2468081641 @default.
- W4387492110 hasRelatedWork W3142747831 @default.
- W4387492110 isParatext "false" @default.
- W4387492110 isRetracted "false" @default.
- W4387492110 workType "article" @default.