Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387492164> ?p ?o ?g. }
- W4387492164 endingPage "101011" @default.
- W4387492164 startingPage "101011" @default.
- W4387492164 abstract "The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is a common mechanism involved in developing multidrug resistance (MDR). Unfortunately, there are currently no approved drugs specifically designed to treat multidrug-resistant cancers, making MDR a significant obstacle to successful chemotherapy. Despite over two decades of research, developing transporter-specific inhibitors for clinical use has proven to be a challenging endeavor. As an alternative approach, drug repurposing has gained traction as a more practical method to discover clinically effective modulators of drug transporters. This involves exploring new indications for already-approved drugs, bypassing the lengthy process of developing novel synthetic inhibitors. In this context, we will discuss the mechanisms of ABC drug transporters ABCB1 and ABCG2, their roles in cancer MDR, and the inhibitors that have been evaluated for their potential to reverse MDR mediated by these drug transporters. Our focus will be on providing an up-to-date report on approved drugs tested for their inhibitory activities against these drug efflux pumps. Lastly, we will explore the challenges and prospects of repurposing already approved medications for clinical use to overcome chemoresistance in patients with high tumor expression of ABCB1 and/or ABCG2." @default.
- W4387492164 created "2023-10-11" @default.
- W4387492164 creator A5002885162 @default.
- W4387492164 creator A5015196276 @default.
- W4387492164 creator A5047307531 @default.
- W4387492164 date "2023-10-01" @default.
- W4387492164 modified "2023-10-12" @default.
- W4387492164 title "Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2" @default.
- W4387492164 cites W1545790530 @default.
- W4387492164 cites W1546346721 @default.
- W4387492164 cites W1568323318 @default.
- W4387492164 cites W1572599368 @default.
- W4387492164 cites W1593902116 @default.
- W4387492164 cites W1599268777 @default.
- W4387492164 cites W1645010355 @default.
- W4387492164 cites W1791352086 @default.
- W4387492164 cites W1841839642 @default.
- W4387492164 cites W1856716148 @default.
- W4387492164 cites W1865794161 @default.
- W4387492164 cites W1905469811 @default.
- W4387492164 cites W1964709116 @default.
- W4387492164 cites W1965060877 @default.
- W4387492164 cites W1966408297 @default.
- W4387492164 cites W1967221808 @default.
- W4387492164 cites W1968173220 @default.
- W4387492164 cites W1971607633 @default.
- W4387492164 cites W1973522717 @default.
- W4387492164 cites W1974447310 @default.
- W4387492164 cites W1977202771 @default.
- W4387492164 cites W1979902556 @default.
- W4387492164 cites W1980132014 @default.
- W4387492164 cites W1980183760 @default.
- W4387492164 cites W1983688434 @default.
- W4387492164 cites W1984246155 @default.
- W4387492164 cites W1986868844 @default.
- W4387492164 cites W1988343883 @default.
- W4387492164 cites W1988737917 @default.
- W4387492164 cites W1989064705 @default.
- W4387492164 cites W1991218028 @default.
- W4387492164 cites W1994197392 @default.
- W4387492164 cites W1995404972 @default.
- W4387492164 cites W1997241897 @default.
- W4387492164 cites W2006434892 @default.
- W4387492164 cites W2006721545 @default.
- W4387492164 cites W2006960455 @default.
- W4387492164 cites W2010017650 @default.
- W4387492164 cites W2012912125 @default.
- W4387492164 cites W2014593961 @default.
- W4387492164 cites W2016098773 @default.
- W4387492164 cites W2017779999 @default.
- W4387492164 cites W2019346113 @default.
- W4387492164 cites W2019490712 @default.
- W4387492164 cites W2024250662 @default.
- W4387492164 cites W2028533496 @default.
- W4387492164 cites W2028723109 @default.
- W4387492164 cites W2033151149 @default.
- W4387492164 cites W2034618224 @default.
- W4387492164 cites W2036459315 @default.
- W4387492164 cites W2039132391 @default.
- W4387492164 cites W2043320183 @default.
- W4387492164 cites W2044703558 @default.
- W4387492164 cites W2047049685 @default.
- W4387492164 cites W2047384307 @default.
- W4387492164 cites W2047543449 @default.
- W4387492164 cites W2049147399 @default.
- W4387492164 cites W2049823629 @default.
- W4387492164 cites W2050767064 @default.
- W4387492164 cites W2056025136 @default.
- W4387492164 cites W2056137128 @default.
- W4387492164 cites W2058235299 @default.
- W4387492164 cites W2058804306 @default.
- W4387492164 cites W2061773900 @default.
- W4387492164 cites W2062133534 @default.
- W4387492164 cites W2063005225 @default.
- W4387492164 cites W2064067180 @default.
- W4387492164 cites W2064808628 @default.
- W4387492164 cites W2067815150 @default.
- W4387492164 cites W2068955206 @default.
- W4387492164 cites W2069391806 @default.
- W4387492164 cites W2069907205 @default.
- W4387492164 cites W2070791205 @default.
- W4387492164 cites W2072517578 @default.
- W4387492164 cites W2076436346 @default.
- W4387492164 cites W2082926784 @default.
- W4387492164 cites W2084600496 @default.
- W4387492164 cites W2085355316 @default.
- W4387492164 cites W2085452141 @default.
- W4387492164 cites W2086195681 @default.
- W4387492164 cites W2086900713 @default.
- W4387492164 cites W2091371557 @default.
- W4387492164 cites W2095624641 @default.
- W4387492164 cites W2096684031 @default.
- W4387492164 cites W2096986950 @default.
- W4387492164 cites W2098064809 @default.
- W4387492164 cites W2101291448 @default.
- W4387492164 cites W2101884133 @default.
- W4387492164 cites W2105130146 @default.
- W4387492164 cites W2105968397 @default.