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- W4387493986 abstract "Genomewide association studies highlight the polygenic nature of neuropsychiatric conditions, meaning that risk is conferred by thousands of variants of small effect. In other fields of medicine, scores based on an individual’s relative burden of disease-associated alleles, or polygenic risk scores (PRS), are showing promise for risk stratification and personalized care. In child and adolescent psychiatry, the utility of PRS in clinical practice is a growing conversation. We will report on the ability for PRS to predict child psychopathology, considering specificity and sex-dependent effects, as well as ways to refine risk models with biologically relevant information, machine learning, and environmental data." @default.
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- W4387493986 date "2023-10-01" @default.
- W4387493986 modified "2023-10-12" @default.
- W4387493986 title "Exploring Polygenic Variation in Youth Mental Health: Setting the Stage for Clinical Risk Prediction" @default.
- W4387493986 doi "https://doi.org/10.1016/j.jaac.2023.07.919" @default.
- W4387493986 hasPublicationYear "2023" @default.
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