FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387494085> ?p ?o ?g. }

• W4387494085 endingPage "117288" @default.
• W4387494085 startingPage "117288" @default.
• W4387494085 abstract "Polygonum perfoliatum L. (PP) is classified as a heat-clearing and detoxifying agent in traditional Chinese medicine, and is believed to possess therapeutic properties for treating eczema, furuncles, and venomous snake bites. Previous studies have demonstrated that PP extract exhibits multiple bioactivities, including antibacterial, anti-inflammatory, antitumor, antioxidation, and antiviral properties. However, no existing studies have evaluated the effects of PP on animal models of atopic dermatitis (AD)-like skin symptoms, which are closely associated with traditional ethnic usage. In present study, therefore, we aimed to explore the potential anti-atopic effect of Polygonum perfoliatum L. ethanol extract (PPE) in 2,4-Dinitrochlorobenzene (DNCB)-induced dermatitis-like skin lesions. For reaching this aim, DNCB-induced mice with AD-like skin inflammation were subjected to topical administration of PPE gels for a period of 21 days, and subsequently, the biological impacts of PPE were evaluated. PPE gels effectively mitigated AD-like skin symptoms induced by DNCB in mice, as demonstrated by a marked reduction in epidermal thickness and dermatitis severity. Moreover, PPE significantly decreased the production of various cytokines, including TNF-α, IL-6, IL-1β, IL-4, IL-5, IL-13 and IgE, in addition to suppressed the production of key inflammation-related enzymes (iNOS and COX-2) and decreased the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB in AD-like skin samples. Furthermore, PPE treatment inhibited the abnormally elevated CD4+/CD8+ ratio in DNCB-induced AD mice. The results of the skin irritation test revealed that PPE exhibited no adverse toxicity in mice at dose of 10 mg/day. PPE exhibits potential as a safe therapeutic agent for atopic dermatitis by efficiently mitigating DNCB-induced atopic symptoms and diminishing inflammation, and does not carry the risk of over-immunosuppression or treatment-associated adverse effects." @default.
• W4387494085 created "2023-10-11" @default.
• W4387494085 creator A5024785349 @default.
• W4387494085 creator A5033391452 @default.
• W4387494085 creator A5036277303 @default.
• W4387494085 creator A5036324138 @default.
• W4387494085 creator A5047515640 @default.
• W4387494085 creator A5067339019 @default.
• W4387494085 creator A5072100190 @default.
• W4387494085 creator A5072679885 @default.
• W4387494085 creator A5077717253 @default.
• W4387494085 date "2023-10-01" @default.
• W4387494085 modified "2023-10-12" @default.
• W4387494085 title "Polygonum perfoliatum L. ethanol extract ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin inflammation" @default.
• W4387494085 cites W1527957830 @default.
• W4387494085 cites W189068515 @default.
• W4387494085 cites W2039603982 @default.
• W4387494085 cites W2111692694 @default.
• W4387494085 cites W2134887638 @default.
• W4387494085 cites W2146929275 @default.
• W4387494085 cites W2189175868 @default.
• W4387494085 cites W2200308911 @default.
• W4387494085 cites W2473541542 @default.
• W4387494085 cites W2604656957 @default.
• W4387494085 cites W2788419948 @default.
• W4387494085 cites W2801208468 @default.
• W4387494085 cites W2872819494 @default.
• W4387494085 cites W2939497858 @default.
• W4387494085 cites W2943979662 @default.
• W4387494085 cites W2951344740 @default.
• W4387494085 cites W2997797983 @default.
• W4387494085 cites W3081085520 @default.
• W4387494085 cites W3084945535 @default.
• W4387494085 cites W3091172085 @default.
• W4387494085 cites W3092100006 @default.
• W4387494085 cites W3098686789 @default.
• W4387494085 cites W3161003780 @default.
• W4387494085 cites W3183410527 @default.
• W4387494085 cites W3208689037 @default.
• W4387494085 cites W4206555987 @default.
• W4387494085 cites W4211013257 @default.
• W4387494085 cites W4211026773 @default.
• W4387494085 cites W4213151738 @default.
• W4387494085 cites W4232712261 @default.
• W4387494085 cites W4286213504 @default.
• W4387494085 doi "https://doi.org/10.1016/j.jep.2023.117288" @default.
• W4387494085 hasPublicationYear "2023" @default.
• W4387494085 type Work @default.
• W4387494085 citedByCount "0" @default.
• W4387494085 crossrefType "journal-article" @default.
• W4387494085 hasAuthorship W4387494085A5024785349 @default.
• W4387494085 hasAuthorship W4387494085A5033391452 @default.
• W4387494085 hasAuthorship W4387494085A5036277303 @default.
• W4387494085 hasAuthorship W4387494085A5036324138 @default.
• W4387494085 hasAuthorship W4387494085A5047515640 @default.
• W4387494085 hasAuthorship W4387494085A5067339019 @default.
• W4387494085 hasAuthorship W4387494085A5072100190 @default.
• W4387494085 hasAuthorship W4387494085A5072679885 @default.
• W4387494085 hasAuthorship W4387494085A5077717253 @default.
• W4387494085 hasConcept C164027704 @default.
• W4387494085 hasConcept C185592680 @default.
• W4387494085 hasConcept C203014093 @default.
• W4387494085 hasConcept C2776914184 @default.
• W4387494085 hasConcept C2778004101 @default.
• W4387494085 hasConcept C2778329239 @default.
• W4387494085 hasConcept C55493867 @default.
• W4387494085 hasConcept C556039675 @default.
• W4387494085 hasConcept C71924100 @default.
• W4387494085 hasConcept C98274493 @default.
• W4387494085 hasConceptScore W4387494085C164027704 @default.
• W4387494085 hasConceptScore W4387494085C185592680 @default.
• W4387494085 hasConceptScore W4387494085C203014093 @default.
• W4387494085 hasConceptScore W4387494085C2776914184 @default.
• W4387494085 hasConceptScore W4387494085C2778004101 @default.
• W4387494085 hasConceptScore W4387494085C2778329239 @default.
• W4387494085 hasConceptScore W4387494085C55493867 @default.
• W4387494085 hasConceptScore W4387494085C556039675 @default.
• W4387494085 hasConceptScore W4387494085C71924100 @default.
• W4387494085 hasConceptScore W4387494085C98274493 @default.
• W4387494085 hasLocation W43874940851 @default.
• W4387494085 hasOpenAccess W4387494085 @default.
• W4387494085 hasPrimaryLocation W43874940851 @default.
• W4387494085 hasRelatedWork W1955721074 @default.
• W4387494085 hasRelatedWork W1992848314 @default.
• W4387494085 hasRelatedWork W2011724047 @default.
• W4387494085 hasRelatedWork W2015667478 @default.
• W4387494085 hasRelatedWork W2392126385 @default.
• W4387494085 hasRelatedWork W2416795054 @default.
• W4387494085 hasRelatedWork W2571013527 @default.
• W4387494085 hasRelatedWork W2944714515 @default.
• W4387494085 hasRelatedWork W3039146159 @default.
• W4387494085 hasRelatedWork W4379052364 @default.
• W4387494085 isParatext "false" @default.
• W4387494085 isRetracted "false" @default.
• W4387494085 workType "article" @default.