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• W4387494105 endingPage "e0289461" @default.
• W4387494105 startingPage "e0289461" @default.
• W4387494105 abstract "Steroids play a crucial role in modulating brain and behavior. While traditionally it is thought that the brain is a target of sex steroids produced in endocrine glands (e.g. gonads), the brain itself produces steroids, known as neurosteroids. Neurosteroids can be produced in regions involved in the regulation of social behaviors and may act locally to regulate social behaviors, such as reproduction and aggression. Our model species, the weakly electric fish Gymnotus omarorum , displays non-breeding aggression in both sexes. This is a valuable natural behavior to understand neuroendocrine mechanisms that differ from those underlying breeding aggression. In the non-breeding season, circulating sex steroid levels are low, which facilitates the study of neurosteroids. Here, for the first time in a teleost fish, we used liquid chromatography-tandem mass spectrometry (LC-MS/MS) to quantify a panel of 8 steroids in both plasma and brain to characterize steroid profiles in wild non-breeding adult males and females. We show that: 1) systemic steroid levels in the non-breeding season are similar in both sexes, although only males have detectable circulating 11-ketotestosterone, 2) brain steroid levels are sexually dimorphic, as females display higher levels of androstenedione, testosterone and estrone, and only males had detectable 11-ketotestosterone, 3) systemic androgens such as androstenedione and testosterone in the non-breeding season are potential precursors for neuroestrogen synthesis, and 4) estrogens, which play a key role in non-breeding aggression, are detectable in the brain (but not the plasma) in both sexes. These data are consistent with previous studies of G . omarorum that show non-breeding aggression is dependent on estrogen signaling, as has also been shown in bird and mammal models. Overall, our results provide a foundation for understanding the role of neurosteroids, the interplay between central and peripheral steroids and potential sex differences in the regulation of social behaviors." @default.
• W4387494105 created "2023-10-11" @default.
• W4387494105 creator A5000757394 @default.
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• W4387494105 creator A5079633771 @default.
• W4387494105 date "2023-10-10" @default.
• W4387494105 modified "2023-10-13" @default.
• W4387494105 title "Brain and circulating steroids in an electric fish: Relevance for non-breeding aggression" @default.
• W4387494105 cites W1563958186 @default.
• W4387494105 cites W1896632304 @default.
• W4387494105 cites W1909481093 @default.
• W4387494105 cites W1954212995 @default.
• W4387494105 cites W1966562279 @default.
• W4387494105 cites W1969474756 @default.
• W4387494105 cites W1969954095 @default.
• W4387494105 cites W1974452009 @default.
• W4387494105 cites W1974657574 @default.
• W4387494105 cites W1979307228 @default.
• W4387494105 cites W1980509664 @default.
• W4387494105 cites W1988166395 @default.
• W4387494105 cites W1988959583 @default.
• W4387494105 cites W1992415333 @default.
• W4387494105 cites W1993558760 @default.
• W4387494105 cites W1995122809 @default.
• W4387494105 cites W1999173400 @default.
• W4387494105 cites W2000037226 @default.
• W4387494105 cites W2003006266 @default.
• W4387494105 cites W2003938622 @default.
• W4387494105 cites W2010181904 @default.
• W4387494105 cites W2023173150 @default.
• W4387494105 cites W2025590886 @default.
• W4387494105 cites W2025778696 @default.
• W4387494105 cites W2029859952 @default.
• W4387494105 cites W2033183411 @default.
• W4387494105 cites W2039299884 @default.
• W4387494105 cites W2044032827 @default.
• W4387494105 cites W2046145277 @default.
• W4387494105 cites W2046232375 @default.
• W4387494105 cites W2046919970 @default.
• W4387494105 cites W2047080508 @default.
• W4387494105 cites W2049302181 @default.
• W4387494105 cites W2050317100 @default.
• W4387494105 cites W2059889644 @default.
• W4387494105 cites W2060624006 @default.
• W4387494105 cites W2073646532 @default.
• W4387494105 cites W2077583222 @default.
• W4387494105 cites W2077678165 @default.
• W4387494105 cites W2079666709 @default.
• W4387494105 cites W2080354544 @default.
• W4387494105 cites W2081797842 @default.
• W4387494105 cites W2092754471 @default.
• W4387494105 cites W2100322375 @default.
• W4387494105 cites W2107382903 @default.
• W4387494105 cites W2116395620 @default.
• W4387494105 cites W2117501262 @default.
• W4387494105 cites W2117556137 @default.
• W4387494105 cites W2121913278 @default.
• W4387494105 cites W2129340811 @default.
• W4387494105 cites W2129836081 @default.
• W4387494105 cites W2144030965 @default.
• W4387494105 cites W2144654425 @default.
• W4387494105 cites W2150735977 @default.
• W4387494105 cites W2153790267 @default.
• W4387494105 cites W2559709790 @default.
• W4387494105 cites W2567677415 @default.
• W4387494105 cites W2588963558 @default.
• W4387494105 cites W274010294 @default.
• W4387494105 cites W2757515646 @default.
• W4387494105 cites W2766453366 @default.
• W4387494105 cites W2791447010 @default.
• W4387494105 cites W2793318989 @default.
• W4387494105 cites W2800582834 @default.
• W4387494105 cites W2803508903 @default.
• W4387494105 cites W2949148219 @default.
• W4387494105 cites W2951837249 @default.
• W4387494105 cites W2955707653 @default.
• W4387494105 cites W2972872578 @default.
• W4387494105 cites W3000706148 @default.
• W4387494105 cites W3007584958 @default.
• W4387494105 cites W3008493757 @default.
• W4387494105 cites W3012450193 @default.
• W4387494105 cites W3034391894 @default.
• W4387494105 cites W3035528350 @default.
• W4387494105 cites W3044242816 @default.
• W4387494105 cites W3085969575 @default.
• W4387494105 cites W3106697182 @default.
• W4387494105 cites W3122727486 @default.
• W4387494105 cites W3131136205 @default.
• W4387494105 cites W3149740099 @default.
• W4387494105 cites W3189960506 @default.
• W4387494105 cites W4212883789 @default.
• W4387494105 cites W4224226811 @default.
• W4387494105 cites W4225463413 @default.
• W4387494105 cites W4226059739 @default.
• W4387494105 cites W4236220967 @default.
• W4387494105 cites W4283795381 @default.

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