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- W4387496146 abstract "Accepting or rejecting a mate is one of the most crucial decisions a female will make, especially when faced with food shortage. Previous studies have identified the core neural circuity from sensing male courtship or mating status to decision-making for sexual receptivity in Drosophila females, but how hunger and satiety states modulate female receptivity is poorly understood. Here, we identify the neural circuit and its neuromodulation underlying the hunger modulation of female receptivity. We find that adipokinetic hormone receptor (AkhR)-expressing neurons inhibit sexual receptivity in a starvation-dependent manner. AkhR neurons are octopaminergic and act on a subset of Octβ1R-expressing LH421 neurons. Knocking down Octβ1R expression in LH421 neurons eliminates starvation-induced suppression of female receptivity. We further find that LH421 neurons inhibit the sex-promoting pC1 neurons via GABA-resistant to dieldrin (Rdl) signaling. pC1 neurons also integrate courtship stimulation and mating status and thus serve as a common integrator of multiple internal and external cues for decision-making." @default.
- W4387496146 created "2023-10-11" @default.
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- W4387496146 date "2023-10-01" @default.
- W4387496146 modified "2023-10-18" @default.
- W4387496146 title "A neural pathway underlying hunger modulation of sexual receptivity in Drosophila females" @default.
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- W4387496146 doi "https://doi.org/10.1016/j.celrep.2023.113243" @default.
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