FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387496672> ?p ?o ?g. }

• W4387496672 endingPage "S146" @default.
• W4387496672 startingPage "S145" @default.
• W4387496672 abstract "Whether psychosis should be considered as a spectrum or as individual psychotic disorders that are discrete entities is currently unclear. This project examines whether there are genetic and phenotypic differences between different psychotic disorder diagnoses in UK Biobank. Participants from UK Biobank were categorised into psychotic disorder groups based on ICD-10 diagnoses from linked hospital records. Individuals with multiple diagnosis were categorised separately. Schizophrenia and intelligence polygenic risk scores (PRS) were calculated using PRS-CS and an ancestry adjustment was applied. Phenotype variables related to demographics, mood and functioning were selected. PRS and phenotypes were compared between each psychotic disorder group and schizophrenia using pairwise logistic regressions. A total of 2012 participants with at least one psychotic disorder diagnosis were included and these were categorised into schizophrenia (N=759), delusional disorder (N=297), acute and transient psychotic disorder (N=165), schizoaffective disorder (N=86), unspecified psychotic disorder (N=265), multiple diagnoses of psychotic disorder (N=219) and co-morbid diagnoses of schizoaffective disorder and schizophrenia (N=121). Compared to individuals with schizophrenia, a lower schizophrenia PRS was observed in those with diagnoses of delusional disorder (OR = 0.80, 95% CI = 0.69,0.92, p = 0.0025), acute and transient psychotic disorder (OR = 0.76, 95% CI=0.63,0.91, p = 0.0027) and unspecified psychotic disorder (OR = 0.73, 95% CI = 0.63,0.86, p = 8.55 × 10-5). Phenotypic differences were also found between psychotic disorder diagnoses; Those with schizophrenia were more likely to be male than those with delusional disorder or schizoaffective disorder. Individuals with acute and transient psychotic disorder, unspecified psychotic disorder, multiple diagnoses, schizoaffective disorder had higher rates of mood comorbidities than those with schizophrenia which in turn had higher rates of mood comorbidities than delusional disorder. Measures of better functioning such as current employment and cohabiting were higher in those with wider psychotic disorder diagnoses than with schizophrenia. We found evidence of genetic and phenotypic differences between individuals with schizophrenia and other psychotic disorder diagnoses in UK Biobank." @default.
• W4387496672 created "2023-10-11" @default.
• W4387496672 creator A5026352442 @default.
• W4387496672 creator A5027152344 @default.
• W4387496672 creator A5035126529 @default.
• W4387496672 creator A5035506012 @default.
• W4387496672 creator A5051744112 @default.
• W4387496672 creator A5054983889 @default.
• W4387496672 creator A5059458620 @default.
• W4387496672 creator A5085438461 @default.
• W4387496672 date "2023-10-01" @default.
• W4387496672 modified "2023-10-18" @default.
• W4387496672 title "W78. PSYCHOTIC DISORDER DIAGNOSES: ARE THEY ALL THE SAME?" @default.
• W4387496672 doi "https://doi.org/10.1016/j.euroneuro.2023.08.265" @default.
• W4387496672 hasPublicationYear "2023" @default.
• W4387496672 type Work @default.
• W4387496672 citedByCount "0" @default.
• W4387496672 crossrefType "journal-article" @default.
• W4387496672 hasAuthorship W4387496672A5026352442 @default.
• W4387496672 hasAuthorship W4387496672A5027152344 @default.
• W4387496672 hasAuthorship W4387496672A5035126529 @default.
• W4387496672 hasAuthorship W4387496672A5035506012 @default.
• W4387496672 hasAuthorship W4387496672A5051744112 @default.
• W4387496672 hasAuthorship W4387496672A5054983889 @default.
• W4387496672 hasAuthorship W4387496672A5059458620 @default.
• W4387496672 hasAuthorship W4387496672A5085438461 @default.
• W4387496672 hasConcept C118552586 @default.
• W4387496672 hasConcept C142724271 @default.
• W4387496672 hasConcept C15744967 @default.
• W4387496672 hasConcept C2776174506 @default.
• W4387496672 hasConcept C2776412080 @default.
• W4387496672 hasConcept C2776601460 @default.
• W4387496672 hasConcept C2779727114 @default.
• W4387496672 hasConcept C2780325297 @default.
• W4387496672 hasConcept C2780733359 @default.
• W4387496672 hasConcept C534262118 @default.
• W4387496672 hasConcept C70410870 @default.
• W4387496672 hasConcept C71924100 @default.
• W4387496672 hasConceptScore W4387496672C118552586 @default.
• W4387496672 hasConceptScore W4387496672C142724271 @default.
• W4387496672 hasConceptScore W4387496672C15744967 @default.
• W4387496672 hasConceptScore W4387496672C2776174506 @default.
• W4387496672 hasConceptScore W4387496672C2776412080 @default.
• W4387496672 hasConceptScore W4387496672C2776601460 @default.
• W4387496672 hasConceptScore W4387496672C2779727114 @default.
• W4387496672 hasConceptScore W4387496672C2780325297 @default.
• W4387496672 hasConceptScore W4387496672C2780733359 @default.
• W4387496672 hasConceptScore W4387496672C534262118 @default.
• W4387496672 hasConceptScore W4387496672C70410870 @default.
• W4387496672 hasConceptScore W4387496672C71924100 @default.
• W4387496672 hasLocation W43874966721 @default.
• W4387496672 hasOpenAccess W4387496672 @default.
• W4387496672 hasPrimaryLocation W43874966721 @default.
• W4387496672 hasRelatedWork W1966891244 @default.
• W4387496672 hasRelatedWork W2071734209 @default.
• W4387496672 hasRelatedWork W2079095729 @default.
• W4387496672 hasRelatedWork W2107954637 @default.
• W4387496672 hasRelatedWork W2160504078 @default.
• W4387496672 hasRelatedWork W228914531 @default.
• W4387496672 hasRelatedWork W2495641272 @default.
• W4387496672 hasRelatedWork W2731707516 @default.
• W4387496672 hasRelatedWork W3185452664 @default.
• W4387496672 hasRelatedWork W4226285087 @default.
• W4387496672 hasVolume "75" @default.
• W4387496672 isParatext "false" @default.
• W4387496672 isRetracted "false" @default.
• W4387496672 workType "article" @default.