FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387496805> ?p ?o ?g. }

• W4387496805 endingPage "S75" @default.
• W4387496805 startingPage "S74" @default.
• W4387496805 abstract "The brain's default mode network (DMN) plays a role in social cognition, with altered DMN connectivity associated with social impairments in neuropsychiatric conditions, such as autism spectrum disorder and psychosis. Both brain networks’ functionality and sociability are heritable. This study aims to uncover possible patterns of shared genetics between sociability and DMN activity/connectivity and to investigate the underlying possible shared genomic regions. We leveraged summary statistics of the largest genome-wide association studies on sociability (N = 342,461) and brain activity/connectivity traits as captured by independent component analysis (ICA) of the resting-state functional magnetic resonance imaging (rsfMRI) signal (N = 34,691). Global and local genetic correlation analyses were conducted using LDSC and Local Analysis of [co]Variant Association (LAVA) on 2,495 semi-independent genomic regions, respectively. FDR correction was applied. Data were filtered to include only rsfMRI traits with non-zero SNP-based heritability (h2SNP > 0.1) and related to the DMN. SNPs from genomic regions showing significant local correlations were mapped to genes using positional and brain eQTLs-based approaches, and their functional relevance was investigated via FUMA. Lastly, colocalization analyses were performed using coloc to explore the potential existence of shared causal variants between sociability and rsfMRI DMN-related traits. In total, 32 activity and 64 connectivity DMN-related rsfMRI traits were included in the analyses. Our findings reveal a significant global genetic correlation between sociability and spontaneous activity in two ICA-defined brain regions located in the temporal, cingulate, and frontal cortex (rg = 0.15, p < 0.002). A strong, local genetic correlation was observed between sociability and spontaneous activity in the temporal cortex (ICA node 17) at chr18:34,153,298-36,056,932 (rg = 0.66, p = 2.1e-4), implicating a cluster of 11 genes. Among these, CELF4 has been linked with speech and communication disorders. No global genetic correlations between sociability and connectivity traits were found. A strong, local genetic correlation was nonetheless identified at chr6:114,255,955-115,588,903 (rg = -0.70, p = 1.7e-4), linking sociability with connectivity between the frontal/cingulate and angular/temporal cortex (ICA nodes 7-11), whose areas involve DMN, but extend to the limbic, and central executive networks. Twenty genes were mapped to this genomic region, with an enrichment for genes genome-wide associated with body mass index (p = 1.95e-6). Notably, this region also mapped potential druggable genes, such as HABP2, CASP7, and ADRB1, the latter being targeted by beta-blockers and antidepressants, among others. Colocalization analyses did not identify any shared causal variants (PP.H4 < 0.006). In conclusion, our study sheds light on the shared genetics between sociability and brain functional signatures of DMN. Identified brain regions showing genetic correlation with sociability are primarily located within the temporal, cingulate, and frontal cortex—integral to the DMN but intriguingly extending to the motor, central executive, and salience networks. This study paves the way for further exploration into the clinical translation of these findings, holding potential to inform novel therapeutic strategies for mental disorders characterised by social impairments and anomalies in these brain areas." @default.
• W4387496805 created "2023-10-11" @default.
• W4387496805 creator A5002640181 @default.
• W4387496805 creator A5017663367 @default.
• W4387496805 creator A5022100095 @default.
• W4387496805 creator A5035014294 @default.
• W4387496805 creator A5038874292 @default.
• W4387496805 creator A5056480595 @default.
• W4387496805 creator A5062596209 @default.
• W4387496805 creator A5082791385 @default.
• W4387496805 creator A5088925734 @default.
• W4387496805 date "2023-10-01" @default.
• W4387496805 modified "2023-10-12" @default.
• W4387496805 title "33. SHARED GENETICS LINKING SOCIABILITY WITH THE BRAIN'S DEFAULT MODE NETWORK" @default.
• W4387496805 doi "https://doi.org/10.1016/j.euroneuro.2023.08.143" @default.
• W4387496805 hasPublicationYear "2023" @default.
• W4387496805 type Work @default.
• W4387496805 citedByCount "0" @default.
• W4387496805 crossrefType "journal-article" @default.
• W4387496805 hasAuthorship W4387496805A5002640181 @default.
• W4387496805 hasAuthorship W4387496805A5017663367 @default.
• W4387496805 hasAuthorship W4387496805A5022100095 @default.
• W4387496805 hasAuthorship W4387496805A5035014294 @default.
• W4387496805 hasAuthorship W4387496805A5038874292 @default.
• W4387496805 hasAuthorship W4387496805A5056480595 @default.
• W4387496805 hasAuthorship W4387496805A5062596209 @default.
• W4387496805 hasAuthorship W4387496805A5082791385 @default.
• W4387496805 hasAuthorship W4387496805A5088925734 @default.
• W4387496805 hasConcept C104317684 @default.
• W4387496805 hasConcept C106208931 @default.
• W4387496805 hasConcept C117220453 @default.
• W4387496805 hasConcept C120843803 @default.
• W4387496805 hasConcept C135763542 @default.
• W4387496805 hasConcept C138496976 @default.
• W4387496805 hasConcept C141516989 @default.
• W4387496805 hasConcept C153209595 @default.
• W4387496805 hasConcept C15744967 @default.
• W4387496805 hasConcept C169760540 @default.
• W4387496805 hasConcept C205778803 @default.
• W4387496805 hasConcept C2524010 @default.
• W4387496805 hasConcept C2778538070 @default.
• W4387496805 hasConcept C2779226451 @default.
• W4387496805 hasConcept C33923547 @default.
• W4387496805 hasConcept C522805319 @default.
• W4387496805 hasConcept C54355233 @default.
• W4387496805 hasConcept C58693492 @default.
• W4387496805 hasConcept C66324658 @default.
• W4387496805 hasConcept C86803240 @default.
• W4387496805 hasConceptScore W4387496805C104317684 @default.
• W4387496805 hasConceptScore W4387496805C106208931 @default.
• W4387496805 hasConceptScore W4387496805C117220453 @default.
• W4387496805 hasConceptScore W4387496805C120843803 @default.
• W4387496805 hasConceptScore W4387496805C135763542 @default.
• W4387496805 hasConceptScore W4387496805C138496976 @default.
• W4387496805 hasConceptScore W4387496805C141516989 @default.
• W4387496805 hasConceptScore W4387496805C153209595 @default.
• W4387496805 hasConceptScore W4387496805C15744967 @default.
• W4387496805 hasConceptScore W4387496805C169760540 @default.
• W4387496805 hasConceptScore W4387496805C205778803 @default.
• W4387496805 hasConceptScore W4387496805C2524010 @default.
• W4387496805 hasConceptScore W4387496805C2778538070 @default.
• W4387496805 hasConceptScore W4387496805C2779226451 @default.
• W4387496805 hasConceptScore W4387496805C33923547 @default.
• W4387496805 hasConceptScore W4387496805C522805319 @default.
• W4387496805 hasConceptScore W4387496805C54355233 @default.
• W4387496805 hasConceptScore W4387496805C58693492 @default.
• W4387496805 hasConceptScore W4387496805C66324658 @default.
• W4387496805 hasConceptScore W4387496805C86803240 @default.
• W4387496805 hasLocation W43874968051 @default.
• W4387496805 hasOpenAccess W4387496805 @default.
• W4387496805 hasPrimaryLocation W43874968051 @default.
• W4387496805 hasRelatedWork W1585336261 @default.
• W4387496805 hasRelatedWork W1593398722 @default.
• W4387496805 hasRelatedWork W2038307665 @default.
• W4387496805 hasRelatedWork W2075991736 @default.
• W4387496805 hasRelatedWork W2143570064 @default.
• W4387496805 hasRelatedWork W2739017149 @default.
• W4387496805 hasRelatedWork W2793605638 @default.
• W4387496805 hasRelatedWork W4253292488 @default.
• W4387496805 hasRelatedWork W4310170658 @default.
• W4387496805 hasRelatedWork W2948361065 @default.
• W4387496805 hasVolume "75" @default.
• W4387496805 isParatext "false" @default.
• W4387496805 isRetracted "false" @default.
• W4387496805 workType "article" @default.