FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387498775> ?p ?o ?g. }

• W4387498775 endingPage "36" @default.
• W4387498775 startingPage "27" @default.
• W4387498775 abstract "Metabolic syndrome is a series of pathologies united by a similar pathogenesis, the end of which, most often, is cardiovascular accidents, which are leaders among the causes of death in the population around the world. Non-alcoholic fatty liver disease (NAFLD) is the hepatic equivalent of the metabolic syndrome, registered earlier than all other equivalents, on the rights of the liver as a first-line energy depot. At the same time, according to multicenter studies, 95% of people with NAFLD (any stage) are not diagnosed with the disease. Clarification of additional risk factors for NAFLD and the presence of a specific biomarker of non-alcoholic liver steatosis would make it possible to stop the vicious cascade of metabolic processes, which in the future can lead to a significant increase in the life expectancy of the population. The potentially high role of Secreted Frizzled Related Protein-4 (SFRP4) adipokine in the early diagnosis of NAFLD is known. The aim of the study was to optimize the early diagnosis of non-alcoholic fatty liver disease using modern indices and biomarkers. Materials and methods. The work was carried out at the Department of Faculty and Hospital Therapy of the Chuvash State University named after I. N. Ulyanov” in the period from 2016 to 2020. This study included several stages: first of all, a retrospective analysis of 1150 outpatient records of patients from several medical organizations of the Chuvash Republic for the period 2016-2018 was carried out. to form two study groups: experimental and control. At the second stage, as a result of applying the exclusion criteria, 162 people remained in the experiment: 110 from the experimental group, 52 from the control group. The subjects of both groups were compared by gender and age, the age range of the subjects varied from 18 to 80 years old with an average value of 48.3 years. Further, the patients undergo a detailed examination, according to the presented plan: Collection of complaints, medical history, objective examination. Laboratory studies (general and biochemical blood tests, lipidogram, assessment of the level of serum adipokine SFRP4). Instrumental studies (ultrasound of the OBP, TE (SAR), ESP with elastometry). Evaluation of the most informative complex indices for the early diagnosis of NAFLD: MI, IVO indices, HSI, FLD-I. Further, all the necessary statistical processing and analysis of the obtained data were performed (Microsoft Office Excel 2016, StatTech v. 2.8.8 (developer - Stattech LLC, Russia)). Results. Accessible (not requiring the use of additional time and material costs) NAFLD indices with the highest sensitivity rates (99.1% and 98.2%, respectively) were MI and IVO. A noticeable direct correlation was traced between MI (p=0.640), moderate - between the IVO (p=0.398) and the elastographically determined index of non-alcoholic liver steatosis. High sensitivity and specificity of skin manifestations (xanthoma, xanthelasma - 69.6% and 89.7% and seborrheic dermatitis - 82.0% and 71.4%) were found in relation to early manifestations of NAFLD. From anthropometric indicators: the CW/CF index has a pronounced (ρ=0.643), CW - moderate (ρ=0.238), and BMI - a weak direct (ρ=0.223) correlation with the elastographically determined index of non-alcoholic liver steatosis. Adipokine SFRP4 correlates (ρ=0.841) with early manifestations of hepatic steatosis in patients, as determined by TE in CAP mode." @default.
• W4387498775 created "2023-10-11" @default.
• W4387498775 creator A5029480124 @default.
• W4387498775 creator A5092310268 @default.
• W4387498775 date "2023-10-09" @default.
• W4387498775 modified "2023-10-12" @default.
• W4387498775 title "Early diagnosis of non-alcoholic fatty liver disease: the role of biomarkers and complex indices of non-alcoholic fatty liver steatosis" @default.
• W4387498775 cites W1428215000 @default.
• W4387498775 cites W1901266863 @default.
• W4387498775 cites W1935068710 @default.
• W4387498775 cites W1968628675 @default.
• W4387498775 cites W1985194097 @default.
• W4387498775 cites W1991095320 @default.
• W4387498775 cites W1998392457 @default.
• W4387498775 cites W2000723491 @default.
• W4387498775 cites W2020381773 @default.
• W4387498775 cites W2042762335 @default.
• W4387498775 cites W2068041970 @default.
• W4387498775 cites W2074318220 @default.
• W4387498775 cites W2101501858 @default.
• W4387498775 cites W2152694273 @default.
• W4387498775 cites W2155428717 @default.
• W4387498775 cites W2204688218 @default.
• W4387498775 cites W2275855081 @default.
• W4387498775 cites W2277732745 @default.
• W4387498775 cites W2320350999 @default.
• W4387498775 cites W2467065439 @default.
• W4387498775 cites W2596942395 @default.
• W4387498775 cites W2784039673 @default.
• W4387498775 cites W2799802046 @default.
• W4387498775 cites W2906945559 @default.
• W4387498775 cites W2963891168 @default.
• W4387498775 cites W2973525039 @default.
• W4387498775 cites W3010293431 @default.
• W4387498775 cites W3040335471 @default.
• W4387498775 cites W3084086629 @default.
• W4387498775 cites W3095216271 @default.
• W4387498775 cites W4206521404 @default.
• W4387498775 cites W4242973202 @default.
• W4387498775 cites W4249834966 @default.
• W4387498775 cites W872824255 @default.
• W4387498775 doi "https://doi.org/10.31146/1682-8658-ecg-216-8-27-36" @default.
• W4387498775 hasPublicationYear "2023" @default.
• W4387498775 type Work @default.
• W4387498775 citedByCount "0" @default.
• W4387498775 crossrefType "journal-article" @default.
• W4387498775 hasAuthorship W4387498775A5029480124 @default.
• W4387498775 hasAuthorship W4387498775A5092310268 @default.
• W4387498775 hasBestOaLocation W43874987751 @default.
• W4387498775 hasConcept C126322002 @default.
• W4387498775 hasConcept C2776175330 @default.
• W4387498775 hasConcept C2777075537 @default.
• W4387498775 hasConcept C2777214474 @default.
• W4387498775 hasConcept C2777575235 @default.
• W4387498775 hasConcept C2778772119 @default.
• W4387498775 hasConcept C2779134260 @default.
• W4387498775 hasConcept C2779478299 @default.
• W4387498775 hasConcept C2780578515 @default.
• W4387498775 hasConcept C2908647359 @default.
• W4387498775 hasConcept C2993741276 @default.
• W4387498775 hasConcept C511355011 @default.
• W4387498775 hasConcept C71924100 @default.
• W4387498775 hasConcept C90924648 @default.
• W4387498775 hasConcept C99454951 @default.
• W4387498775 hasConceptScore W4387498775C126322002 @default.
• W4387498775 hasConceptScore W4387498775C2776175330 @default.
• W4387498775 hasConceptScore W4387498775C2777075537 @default.
• W4387498775 hasConceptScore W4387498775C2777214474 @default.
• W4387498775 hasConceptScore W4387498775C2777575235 @default.
• W4387498775 hasConceptScore W4387498775C2778772119 @default.
• W4387498775 hasConceptScore W4387498775C2779134260 @default.
• W4387498775 hasConceptScore W4387498775C2779478299 @default.
• W4387498775 hasConceptScore W4387498775C2780578515 @default.
• W4387498775 hasConceptScore W4387498775C2908647359 @default.
• W4387498775 hasConceptScore W4387498775C2993741276 @default.
• W4387498775 hasConceptScore W4387498775C511355011 @default.
• W4387498775 hasConceptScore W4387498775C71924100 @default.
• W4387498775 hasConceptScore W4387498775C90924648 @default.
• W4387498775 hasConceptScore W4387498775C99454951 @default.
• W4387498775 hasIssue "8" @default.
• W4387498775 hasLocation W43874987751 @default.
• W4387498775 hasOpenAccess W4387498775 @default.
• W4387498775 hasPrimaryLocation W43874987751 @default.
• W4387498775 hasRelatedWork W150690066 @default.
• W4387498775 hasRelatedWork W2049962639 @default.
• W4387498775 hasRelatedWork W2054571656 @default.
• W4387498775 hasRelatedWork W2067174853 @default.
• W4387498775 hasRelatedWork W2905664713 @default.
• W4387498775 hasRelatedWork W2955712732 @default.
• W4387498775 hasRelatedWork W4249467801 @default.
• W4387498775 hasRelatedWork W4303648544 @default.
• W4387498775 hasRelatedWork W4312776625 @default.
• W4387498775 hasRelatedWork W4319592531 @default.
• W4387498775 isParatext "false" @default.
• W4387498775 isRetracted "false" @default.
• W4387498775 workType "article" @default.