FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387499168> ?p ?o ?g. }

• W4387499168 abstract "Glioblastoma (GBM) is fatal and the study of therapeutic resistance, disease progression, and drug discovery in GBM or glioma stem cells is often hindered by limited resources. This limitation slows down progress in both drug discovery and patient survival. Here we present a genetically engineered human cerebral organoid model with a cancer-like phenotype that could provide a basis for GBM-like models. Specifically, we engineered a doxycycline-inducible vector encoding shRNAs enabling depletion of the TP53, PTEN, and NF1 tumor suppressors in human cerebral organoids. Designated as inducible short hairpin-TP53-PTEN-NF1 (ish-TPN), doxycycline treatment resulted in human cancer-like cerebral organoids that effaced the entire organoid cytoarchitecture, while uninduced ish-TPN cerebral organoids recapitulated the normal cytoarchitecture of the brain. Transcriptomic analysis revealed a proneural GBM subtype. This proof-of-concept study offers a valuable resource for directly investigating the emergence and progression of gliomas within the context of specific genetic alterations in normal cerebral organoids." @default.
• W4387499168 created "2023-10-11" @default.
• W4387499168 creator A5003642180 @default.
• W4387499168 creator A5009622274 @default.
• W4387499168 creator A5012403937 @default.
• W4387499168 creator A5022390263 @default.
• W4387499168 creator A5024320077 @default.
• W4387499168 creator A5026429908 @default.
• W4387499168 creator A5032197676 @default.
• W4387499168 creator A5032225706 @default.
• W4387499168 creator A5040443011 @default.
• W4387499168 creator A5041031733 @default.
• W4387499168 creator A5048760640 @default.
• W4387499168 creator A5053330465 @default.
• W4387499168 creator A5072374777 @default.
• W4387499168 creator A5078430829 @default.
• W4387499168 creator A5087117639 @default.
• W4387499168 creator A5091055038 @default.
• W4387499168 date "2023-10-10" @default.
• W4387499168 modified "2023-10-17" @default.
• W4387499168 title "TP53-PTEN-NF1 depletion in human brain organoids produces a glioma phenotype in vitro" @default.
• W4387499168 cites W1964692745 @default.
• W4387499168 cites W1984637659 @default.
• W4387499168 cites W2001544973 @default.
• W4387499168 cites W2007028593 @default.
• W4387499168 cites W2010677999 @default.
• W4387499168 cites W2018286352 @default.
• W4387499168 cites W2018607339 @default.
• W4387499168 cites W2018671779 @default.
• W4387499168 cites W2026541878 @default.
• W4387499168 cites W2060551076 @default.
• W4387499168 cites W2065970275 @default.
• W4387499168 cites W2100553819 @default.
• W4387499168 cites W2105528101 @default.
• W4387499168 cites W2109531556 @default.
• W4387499168 cites W2109816625 @default.
• W4387499168 cites W2113942802 @default.
• W4387499168 cites W2144908865 @default.
• W4387499168 cites W2150699398 @default.
• W4387499168 cites W2167377849 @default.
• W4387499168 cites W2176412441 @default.
• W4387499168 cites W2286284214 @default.
• W4387499168 cites W2503650298 @default.
• W4387499168 cites W2553575642 @default.
• W4387499168 cites W2595863515 @default.
• W4387499168 cites W2613290483 @default.
• W4387499168 cites W2738946651 @default.
• W4387499168 cites W2790807198 @default.
• W4387499168 cites W2799441834 @default.
• W4387499168 cites W2802314931 @default.
• W4387499168 cites W2883445821 @default.
• W4387499168 cites W2884741638 @default.
• W4387499168 cites W2885447929 @default.
• W4387499168 cites W2886368623 @default.
• W4387499168 cites W2887945559 @default.
• W4387499168 cites W2921139978 @default.
• W4387499168 cites W2922854104 @default.
• W4387499168 cites W2942868704 @default.
• W4387499168 cites W2971447484 @default.
• W4387499168 cites W2997979341 @default.
• W4387499168 cites W2999554785 @default.
• W4387499168 cites W3014253386 @default.
• W4387499168 cites W3020099303 @default.
• W4387499168 cites W3030339055 @default.
• W4387499168 cites W3033033526 @default.
• W4387499168 cites W3196326021 @default.
• W4387499168 cites W3213850471 @default.
• W4387499168 doi "https://doi.org/10.3389/fonc.2023.1279806" @default.
• W4387499168 hasPublicationYear "2023" @default.
• W4387499168 type Work @default.
• W4387499168 citedByCount "0" @default.
• W4387499168 crossrefType "journal-article" @default.
• W4387499168 hasAuthorship W4387499168A5003642180 @default.
• W4387499168 hasAuthorship W4387499168A5009622274 @default.
• W4387499168 hasAuthorship W4387499168A5012403937 @default.
• W4387499168 hasAuthorship W4387499168A5022390263 @default.
• W4387499168 hasAuthorship W4387499168A5024320077 @default.
• W4387499168 hasAuthorship W4387499168A5026429908 @default.
• W4387499168 hasAuthorship W4387499168A5032197676 @default.
• W4387499168 hasAuthorship W4387499168A5032225706 @default.
• W4387499168 hasAuthorship W4387499168A5040443011 @default.
• W4387499168 hasAuthorship W4387499168A5041031733 @default.
• W4387499168 hasAuthorship W4387499168A5048760640 @default.
• W4387499168 hasAuthorship W4387499168A5053330465 @default.
• W4387499168 hasAuthorship W4387499168A5072374777 @default.
• W4387499168 hasAuthorship W4387499168A5078430829 @default.
• W4387499168 hasAuthorship W4387499168A5087117639 @default.
• W4387499168 hasAuthorship W4387499168A5091055038 @default.
• W4387499168 hasBestOaLocation W43874991681 @default.
• W4387499168 hasConcept C104317684 @default.
• W4387499168 hasConcept C127716648 @default.
• W4387499168 hasConcept C142724271 @default.
• W4387499168 hasConcept C150194340 @default.
• W4387499168 hasConcept C162317418 @default.
• W4387499168 hasConcept C169760540 @default.
• W4387499168 hasConcept C2777609662 @default.
• W4387499168 hasConcept C2778227246 @default.
• W4387499168 hasConcept C2779130545 @default.
• W4387499168 hasConcept C31695470 @default.
• W4387499168 hasConcept C502942594 @default.

• next