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- W4387500312 abstract "Abstract The envelope glycoproteins (Env) of retroviruses are highly diverse due to their relatively rapid evolution and the ancient origin of retroviruses. Sequence similarity among the Env of retroviruses is observed in the transmembrane subunit (TM) of Env mediating membrane fusion, whereas this similarity is more limited or absent in the surface subunit (SU) mediating receptor binding. Recent structural modeling of the SU of the major orthoretroviral groups identified a structurally conserved β-sheet domain in SU and the SU-equivalent of the filoviruses, GP1, that is differentially expanded to generate the structural diversity observed in this protein family. Here, the evolution of the trimeric gamma-type Env of gammaretroviruses and alpharetroviruses is addressed by structural modeling using AlphaFold2. The trimeric murine leukemia virus (MLV) and avian leukemia virus Env models show a close structural relationship between trimeric Env proteins of gammaretroviruses and alpharetroviruses and the filoviral spike protein, with an extended hydrophobic structure anchoring SU into TM in the retroviral gamma-type Env occluding the intersubunit disulfide bond. In addition, the structural model of trimeric MLV Env indicates that the receptor binding domains (RBD) of gammaretroviral Env are positioned on the side of the Env trimer pointing towards the viral envelope membrane. The trimeric MLV Env structural model, including RBD position, is consistent with previous trimeric Env electron-density maps. The structural models provide insights into the structure, function and evolution of trimeric, pre-fusion gamma-type Env of gammaretroviruses and alpharetroviruses." @default.
- W4387500312 created "2023-10-11" @default.
- W4387500312 creator A5034786616 @default.
- W4387500312 date "2023-10-09" @default.
- W4387500312 modified "2023-10-15" @default.
- W4387500312 title "Structural Evolution of Trimeric Gamma-Type Retroviral Envelope Proteins" @default.
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- W4387500312 doi "https://doi.org/10.1101/2023.10.07.561363" @default.
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