Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387500466> ?p ?o ?g. }
- W4387500466 abstract "Mycobacterium tuberculosis phosphoserine phosphatase MtSerB2 is of interest as a new antituberculosis target due to its essential metabolic role in L-serine biosynthesis and effector functions in infected cells. Previous works indicated that MtSerB2 is regulated through an oligomeric transition induced by L-Ser that could serve as a basis for the design of selective allosteric inhibitors. However, the mechanism underlying this transition remains highly elusive due to the lack of experimental structural data. Here we describe a structural, biophysical, and enzymological characterisation of MtSerB2 oligomerisation in the presence and absence of L-Ser. We show that MtSerB2 coexists in dimeric, trimeric, and tetrameric forms of different activity levels interconverting through a conformationally flexible monomeric state, which is not observed in two near-identical mycobacterial orthologs. This morpheein behaviour exhibited by MtSerB2 lays the foundation for future allosteric drug discovery and provides a starting point to the understanding of its peculiar multifunctional moonlighting properties." @default.
- W4387500466 created "2023-10-11" @default.
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- W4387500466 creator A5093036734 @default.
- W4387500466 date "2023-10-10" @default.
- W4387500466 modified "2023-10-13" @default.
- W4387500466 title "A morpheein equilibrium regulates catalysis in phosphoserine phosphatase SerB2 from Mycobacterium tuberculosis" @default.
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- W4387500466 doi "https://doi.org/10.1038/s42003-023-05402-z" @default.
- W4387500466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37817000" @default.
- W4387500466 hasPublicationYear "2023" @default.
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