Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387500818> ?p ?o ?g. }
- W4387500818 abstract "Although macrophages contribute to cancer cell dissemination, immune evasion, and metastatic outgrowth, they have also been reported to coordinate tumor-specific immune responses. We therefore hypothesized that macrophage polarization could be modulated therapeutically to prevent metastasis. Here, we show that macrophages respond to β-glucan (odetiglucan) treatment by inhibiting liver metastasis. β-glucan activated liver-resident macrophages (Kupffer cells), suppressed cancer cell proliferation, and invoked productive T cell-mediated responses against liver metastasis in pancreatic cancer mouse models. Although excluded from metastatic lesions, Kupffer cells were critical for the anti-metastatic activity of β-glucan, which also required T cells. Furthermore, β-glucan drove T cell activation and macrophage re-polarization in liver metastases in mice and humans and sensitized metastatic lesions to anti-PD1 therapy. These findings demonstrate the significance of macrophage function in metastasis and identify Kupffer cells as a potential therapeutic target against pancreatic cancer metastasis to the liver." @default.
- W4387500818 created "2023-10-11" @default.
- W4387500818 creator A5001135117 @default.
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- W4387500818 date "2023-10-10" @default.
- W4387500818 modified "2023-10-14" @default.
- W4387500818 title "Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice" @default.
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