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• W4387501719 abstract "Transcutaneous acupoint electrical stimulation (TEAS) has been shown to improve postoperative cognitive dysfunction (POCD) in geriatric cancer patients. However, further research is needed to clarify the optimal timing for TEAS in the context of POCD. This was a prospective, single-centre, single-blinded, randomized controlled trial. 266 geriatric patients who underwent radical resection of gastrointestinal tumors will be divided into seven groups. These groups include one control group (receiving standardized perioperative management), one sham intervention group (TEAS treatment without electronic stimulation), and five intervention groups (TEAS treatment at different time intervals). The sham intervention group and intervention groups will receive TEAS on bilateral Neiguan (PC6) and Zusanli (ST36) acupoints, with Yintang (GV29) being stimulated unilaterally. The TEAS treatment will use an altered frequency of 2/100 Hz, disperse-dense waves, and an adjustable intensity of less than 10 mA. The primary outcome will assess changes in cognition, measured using neuropsychological tests administered preoperatively and three days postoperatively, as well as the Telephone Interview for Cognitive Status-Modified (TICS-m) at one, three, and six months postoperatively. Secondary outcomes will include preoperative and three-day postoperative measurements of Interleukin-6 (IL-6), S100 calcium protein β (S100β), Tumor necrosis factor(TNF-α), Insulin-like growth factor-1 (IGF-1), and C-reactive protein (CRP). Additional data will be collected regarding the time of postoperative exhaust, defecation, eating, and the first postoperative ambulation. Numeric Rating Scale (NRS) scores will also be recorded before and on the third day after the operation, in addition to Activities of Daily Living (ADL) and Braden scale scores, which will be assessed before the operation and at the time of discharge using case records. Statistical analyses will involve the use of analysis of variance (ANOVA), Kruskal-Wallis H-test, chi-squared test, and Fisher's exact test. This study represents the first attempt to evaluate whether varying periods of TEAS can have an impact on POCD and, more importantly, to determine the optimal timing for TEAS to effectively improve POCD." @default.
• W4387501719 created "2023-10-11" @default.
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• W4387501719 date "2023-10-01" @default.
• W4387501719 modified "2023-10-12" @default.
• W4387501719 title "Timing of transcutaneous acupoint electrical stimulation on postoperative recovery in geriatric patients with gastrointestinal tumour: A protocol of the randomized controlled trial" @default.
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• W4387501719 doi "https://doi.org/10.1016/j.conctc.2023.101215" @default.
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