FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387504591> ?p ?o ?g. }

• W4387504591 endingPage "115845" @default.
• W4387504591 startingPage "115845" @default.
• W4387504591 abstract "Inflammatory bowel diseases (IBD) represent chronic gastrointestinal inflammatory disorders characterized by a complex and underexplored pathogenic mechanism. Previous research has revealed that IBD patients often have a deficiency of choline and its metabolites, including acetylcholine (ACh) and phosphatidylcholine (PC), within the colon. However, a comprehensive study linking these three substances and their mechanistic implications in IBD remains lacking. This study aimed to investigate the efficacy and underlying mechanism of cytidine diphosphate (CDP)-choline (citicoline), an intermediate product of choline metabolism, in a mouse model of IBD induced by dextran sulfate sodium salt (DSS). The results demonstrated that CDP-choline effectively alleviated colonic inflammation and deficiencies in choline, ACh, and PC by increasing the raw material. Further detection showed that CDP-choline also increased the ACh content by altering the expression of high-affinity choline transporter (ChT1) and acetylcholinesterase (AChE) in DSS-induced mice colon. Moreover, CDP-choline increased the expression of alpha7 nicotinic acetylcholine receptor (α7 nAChR) and activated the cholinergic anti-inflammatory pathway (CAP), leading to reduced colon macrophage activation and proinflammatory M1 polarization in IBD mice, thus reducing the levels of TNF-α and IL-6. In addition, CDP-choline reduced intestinal ecological imbalance and increased the content of hexanoic acid in short-chain fatty acids (SCFAs) in mice. In conclusion, this study elucidates the ability of CDP-choline to mitigate DSS-induced colon inflammation by addressing choline and its metabolites deficiencies, activating the CAP, and regulating the composition of the intestinal microbiome and SCFAs content, providing a potential prophylactic and therapeutic approach for IBD." @default.
• W4387504591 created "2023-10-11" @default.
• W4387504591 creator A5003415305 @default.
• W4387504591 creator A5015736004 @default.
• W4387504591 creator A5019171181 @default.
• W4387504591 creator A5025428814 @default.
• W4387504591 creator A5033301683 @default.
• W4387504591 creator A5039141475 @default.
• W4387504591 creator A5082263153 @default.
• W4387504591 date "2023-10-01" @default.
• W4387504591 modified "2023-10-14" @default.
• W4387504591 title "CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease" @default.
• W4387504591 cites W1969507309 @default.
• W4387504591 cites W1986386190 @default.
• W4387504591 cites W2001361614 @default.
• W4387504591 cites W2024346860 @default.
• W4387504591 cites W2051256772 @default.
• W4387504591 cites W2073295417 @default.
• W4387504591 cites W2090201519 @default.
• W4387504591 cites W2164457162 @default.
• W4387504591 cites W2166757392 @default.
• W4387504591 cites W2168682720 @default.
• W4387504591 cites W2609398719 @default.
• W4387504591 cites W2767674328 @default.
• W4387504591 cites W2781999873 @default.
• W4387504591 cites W2896011713 @default.
• W4387504591 cites W2924306602 @default.
• W4387504591 cites W2956799311 @default.
• W4387504591 cites W2988471964 @default.
• W4387504591 cites W3006796998 @default.
• W4387504591 cites W3026140883 @default.
• W4387504591 cites W3049074705 @default.
• W4387504591 cites W3092414921 @default.
• W4387504591 cites W3109043421 @default.
• W4387504591 cites W3125542745 @default.
• W4387504591 cites W3133511501 @default.
• W4387504591 cites W3136109505 @default.
• W4387504591 cites W3137815362 @default.
• W4387504591 cites W3156648528 @default.
• W4387504591 cites W3156847384 @default.
• W4387504591 cites W3178558685 @default.
• W4387504591 cites W3186603396 @default.
• W4387504591 cites W3190932060 @default.
• W4387504591 cites W3201482214 @default.
• W4387504591 cites W3204521983 @default.
• W4387504591 cites W3206352177 @default.
• W4387504591 cites W4220900172 @default.
• W4387504591 cites W4220950819 @default.
• W4387504591 cites W4220980261 @default.
• W4387504591 cites W4221007122 @default.
• W4387504591 cites W4229447188 @default.
• W4387504591 cites W4280529994 @default.
• W4387504591 cites W4281797937 @default.
• W4387504591 cites W4283391702 @default.
• W4387504591 cites W4288514112 @default.
• W4387504591 cites W4293574543 @default.
• W4387504591 cites W4310038927 @default.
• W4387504591 cites W4313245713 @default.
• W4387504591 doi "https://doi.org/10.1016/j.bcp.2023.115845" @default.
• W4387504591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37827341" @default.
• W4387504591 hasPublicationYear "2023" @default.
• W4387504591 type Work @default.
• W4387504591 citedByCount "0" @default.
• W4387504591 crossrefType "journal-article" @default.
• W4387504591 hasAuthorship W4387504591A5003415305 @default.
• W4387504591 hasAuthorship W4387504591A5015736004 @default.
• W4387504591 hasAuthorship W4387504591A5019171181 @default.
• W4387504591 hasAuthorship W4387504591A5025428814 @default.
• W4387504591 hasAuthorship W4387504591A5033301683 @default.
• W4387504591 hasAuthorship W4387504591A5039141475 @default.
• W4387504591 hasAuthorship W4387504591A5082263153 @default.
• W4387504591 hasBestOaLocation W43875045911 @default.
• W4387504591 hasConcept C126322002 @default.
• W4387504591 hasConcept C164027704 @default.
• W4387504591 hasConcept C185592680 @default.
• W4387504591 hasConcept C198399640 @default.
• W4387504591 hasConcept C203014093 @default.
• W4387504591 hasConcept C22885893 @default.
• W4387504591 hasConcept C2775910092 @default.
• W4387504591 hasConcept C2776330855 @default.
• W4387504591 hasConcept C2776914184 @default.
• W4387504591 hasConcept C2778260677 @default.
• W4387504591 hasConcept C2778918659 @default.
• W4387504591 hasConcept C2779134260 @default.
• W4387504591 hasConcept C2781123555 @default.
• W4387504591 hasConcept C41625074 @default.
• W4387504591 hasConcept C55493867 @default.
• W4387504591 hasConcept C71924100 @default.
• W4387504591 hasConcept C98274493 @default.
• W4387504591 hasConceptScore W4387504591C126322002 @default.
• W4387504591 hasConceptScore W4387504591C164027704 @default.
• W4387504591 hasConceptScore W4387504591C185592680 @default.
• W4387504591 hasConceptScore W4387504591C198399640 @default.
• W4387504591 hasConceptScore W4387504591C203014093 @default.
• W4387504591 hasConceptScore W4387504591C22885893 @default.
• W4387504591 hasConceptScore W4387504591C2775910092 @default.
• W4387504591 hasConceptScore W4387504591C2776330855 @default.
• W4387504591 hasConceptScore W4387504591C2776914184 @default.

• next