Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387514170> ?p ?o ?g. }
- W4387514170 abstract "Pulmonary hypertension (PH) due to chronic obstructive pulmonary disease (COPD) is classified as Group 3 PH, with no current proven targeted therapies. Studies suggest that cigarette smoke, the most risk factor for COPD can cause vascular remodelling and eventually PH as a result of dysfunction and proliferation of pulmonary artery smooth muscle cells (PASMCs) and pulmonary artery endothelial cells (PAECs). In addition, hypoxia is a known driver of pulmonary vascular remodelling in COPD, and it is also thought that the presence of hypoxia in patients with COPD may further exaggerate cigarette smoke-induced vascular remodelling; however, the underlying cause is not fully understood. Three main pathways (prostanoids, nitric oxide and endothelin) are currently used as a therapeutic target for the treatment of patients with different groups of PH. However, drugs targeting these three pathways are not approved for patients with COPD-associated PH due to lack of evidence. Thus, this review aims to shed light on the role of impaired prostanoids, nitric oxide and endothelin pathways in cigarette smoke- and hypoxia-induced pulmonary vascular remodelling and also discusses the potential of using these pathways as therapeutic target for patients with PH secondary to COPD." @default.
- W4387514170 created "2023-10-11" @default.
- W4387514170 creator A5006829648 @default.
- W4387514170 creator A5009673494 @default.
- W4387514170 creator A5010314662 @default.
- W4387514170 creator A5034076654 @default.
- W4387514170 creator A5038449544 @default.
- W4387514170 creator A5053772815 @default.
- W4387514170 creator A5068006120 @default.
- W4387514170 creator A5073153444 @default.
- W4387514170 creator A5079846677 @default.
- W4387514170 creator A5092814193 @default.
- W4387514170 date "2023-10-10" @default.
- W4387514170 modified "2023-10-12" @default.
- W4387514170 title "Role of prostanoids, nitric oxide and endothelin pathways in pulmonary hypertension due to COPD" @default.
- W4387514170 cites W1529308608 @default.
- W4387514170 cites W1545272792 @default.
- W4387514170 cites W155948172 @default.
- W4387514170 cites W1775672048 @default.
- W4387514170 cites W180821421 @default.
- W4387514170 cites W1840736932 @default.
- W4387514170 cites W1863248742 @default.
- W4387514170 cites W1947179942 @default.
- W4387514170 cites W1964027526 @default.
- W4387514170 cites W1967641836 @default.
- W4387514170 cites W1967889565 @default.
- W4387514170 cites W1968424525 @default.
- W4387514170 cites W1972110742 @default.
- W4387514170 cites W1974227996 @default.
- W4387514170 cites W1977856772 @default.
- W4387514170 cites W1982606698 @default.
- W4387514170 cites W1988773573 @default.
- W4387514170 cites W1989792368 @default.
- W4387514170 cites W1990906728 @default.
- W4387514170 cites W1993592556 @default.
- W4387514170 cites W1999698355 @default.
- W4387514170 cites W2000866488 @default.
- W4387514170 cites W2001439220 @default.
- W4387514170 cites W2003426183 @default.
- W4387514170 cites W2003879854 @default.
- W4387514170 cites W2004067421 @default.
- W4387514170 cites W2006137017 @default.
- W4387514170 cites W2009283881 @default.
- W4387514170 cites W2009628763 @default.
- W4387514170 cites W2010245527 @default.
- W4387514170 cites W2023712580 @default.
- W4387514170 cites W2027267084 @default.
- W4387514170 cites W2029429802 @default.
- W4387514170 cites W2031839314 @default.
- W4387514170 cites W2034318811 @default.
- W4387514170 cites W2035455139 @default.
- W4387514170 cites W2037049861 @default.
- W4387514170 cites W2038197749 @default.
- W4387514170 cites W2043979243 @default.
- W4387514170 cites W2045558844 @default.
- W4387514170 cites W2048443661 @default.
- W4387514170 cites W2048494171 @default.
- W4387514170 cites W2055693070 @default.
- W4387514170 cites W2064883570 @default.
- W4387514170 cites W2066965661 @default.
- W4387514170 cites W2076154824 @default.
- W4387514170 cites W2077356424 @default.
- W4387514170 cites W2077892436 @default.
- W4387514170 cites W2078669201 @default.
- W4387514170 cites W2079063592 @default.
- W4387514170 cites W2079648278 @default.
- W4387514170 cites W2081072140 @default.
- W4387514170 cites W2081803347 @default.
- W4387514170 cites W2081953970 @default.
- W4387514170 cites W2086006446 @default.
- W4387514170 cites W2090213540 @default.
- W4387514170 cites W2091845048 @default.
- W4387514170 cites W2091900055 @default.
- W4387514170 cites W2092353813 @default.
- W4387514170 cites W2093943199 @default.
- W4387514170 cites W2097549671 @default.
- W4387514170 cites W2098180530 @default.
- W4387514170 cites W2099314224 @default.
- W4387514170 cites W2101697517 @default.
- W4387514170 cites W2102522559 @default.
- W4387514170 cites W2107183424 @default.
- W4387514170 cites W2107833029 @default.
- W4387514170 cites W2110163221 @default.
- W4387514170 cites W2113236035 @default.
- W4387514170 cites W2113660065 @default.
- W4387514170 cites W2113836310 @default.
- W4387514170 cites W2116577541 @default.
- W4387514170 cites W2118726397 @default.
- W4387514170 cites W2121607255 @default.
- W4387514170 cites W2122108156 @default.
- W4387514170 cites W2122263917 @default.
- W4387514170 cites W2122606436 @default.
- W4387514170 cites W2124275351 @default.
- W4387514170 cites W2126106992 @default.
- W4387514170 cites W2126853519 @default.
- W4387514170 cites W2127131462 @default.
- W4387514170 cites W2130449101 @default.
- W4387514170 cites W2137146936 @default.
- W4387514170 cites W2137720222 @default.
- W4387514170 cites W2137995623 @default.