Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387515607> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4387515607 abstract "The transcriptional co-regulator SIN3 influences gene expression through multiple interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are the underlying cause of Witteveen-Kolk syndrome and related intellectual disability and autism syndromes, emphasizing its key role in development. However, little is known about the diversity of its interactions and functions in developmental processes. Here, we show that loss of SIN-3, the single SIN3 homolog in Caenorhabditis elegans, results in maternal-effect sterility associated with de-regulation of the germline transcriptome, including de-silencing of X-linked genes. We identify at least two distinct SIN3 complexes containing specific histone deacetylases and show that they differentially contribute to fertility. Single-cell, single-molecule fluorescence in situ hybridization reveals that in sin-3 mutants the X chromosome becomes re-expressed prematurely and in a stochastic manner in individual germ cells, suggesting a role for SIN-3 in its silencing. Furthermore, we identify histone residues whose acetylation increases in the absence of SIN-3. Together, this work provides a powerful framework for the in vivo study of SIN3 and associated proteins." @default.
- W4387515607 created "2023-10-12" @default.
- W4387515607 creator A5031421266 @default.
- W4387515607 creator A5042828826 @default.
- W4387515607 creator A5045096765 @default.
- W4387515607 creator A5048381688 @default.
- W4387515607 creator A5052592686 @default.
- W4387515607 creator A5060636305 @default.
- W4387515607 creator A5074964939 @default.
- W4387515607 creator A5085304931 @default.
- W4387515607 creator A5085954072 @default.
- W4387515607 creator A5086503462 @default.
- W4387515607 date "2023-10-11" @default.
- W4387515607 modified "2023-10-18" @default.
- W4387515607 title "SIN3 acts in distinct complexes to regulate the germline transcriptional program in <i>C. elegans</i>" @default.
- W4387515607 doi "https://doi.org/10.1242/dev.201755" @default.
- W4387515607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37818613" @default.
- W4387515607 hasPublicationYear "2023" @default.
- W4387515607 type Work @default.
- W4387515607 citedByCount "0" @default.
- W4387515607 crossrefType "journal-article" @default.
- W4387515607 hasAuthorship W4387515607A5031421266 @default.
- W4387515607 hasAuthorship W4387515607A5042828826 @default.
- W4387515607 hasAuthorship W4387515607A5045096765 @default.
- W4387515607 hasAuthorship W4387515607A5048381688 @default.
- W4387515607 hasAuthorship W4387515607A5052592686 @default.
- W4387515607 hasAuthorship W4387515607A5060636305 @default.
- W4387515607 hasAuthorship W4387515607A5074964939 @default.
- W4387515607 hasAuthorship W4387515607A5085304931 @default.
- W4387515607 hasAuthorship W4387515607A5085954072 @default.
- W4387515607 hasAuthorship W4387515607A5086503462 @default.
- W4387515607 hasBestOaLocation W43875156071 @default.
- W4387515607 hasConcept C101762097 @default.
- W4387515607 hasConcept C104317684 @default.
- W4387515607 hasConcept C109825262 @default.
- W4387515607 hasConcept C119056186 @default.
- W4387515607 hasConcept C127716648 @default.
- W4387515607 hasConcept C150194340 @default.
- W4387515607 hasConcept C27153228 @default.
- W4387515607 hasConcept C2778944004 @default.
- W4387515607 hasConcept C2780914512 @default.
- W4387515607 hasConcept C54355233 @default.
- W4387515607 hasConcept C64927066 @default.
- W4387515607 hasConcept C68838962 @default.
- W4387515607 hasConcept C6929976 @default.
- W4387515607 hasConcept C86803240 @default.
- W4387515607 hasConcept C95444343 @default.
- W4387515607 hasConceptScore W4387515607C101762097 @default.
- W4387515607 hasConceptScore W4387515607C104317684 @default.
- W4387515607 hasConceptScore W4387515607C109825262 @default.
- W4387515607 hasConceptScore W4387515607C119056186 @default.
- W4387515607 hasConceptScore W4387515607C127716648 @default.
- W4387515607 hasConceptScore W4387515607C150194340 @default.
- W4387515607 hasConceptScore W4387515607C27153228 @default.
- W4387515607 hasConceptScore W4387515607C2778944004 @default.
- W4387515607 hasConceptScore W4387515607C2780914512 @default.
- W4387515607 hasConceptScore W4387515607C54355233 @default.
- W4387515607 hasConceptScore W4387515607C64927066 @default.
- W4387515607 hasConceptScore W4387515607C68838962 @default.
- W4387515607 hasConceptScore W4387515607C6929976 @default.
- W4387515607 hasConceptScore W4387515607C86803240 @default.
- W4387515607 hasConceptScore W4387515607C95444343 @default.
- W4387515607 hasLocation W43875156071 @default.
- W4387515607 hasLocation W43875156072 @default.
- W4387515607 hasLocation W43875156073 @default.
- W4387515607 hasOpenAccess W4387515607 @default.
- W4387515607 hasPrimaryLocation W43875156071 @default.
- W4387515607 hasRelatedWork W1989367421 @default.
- W4387515607 hasRelatedWork W2057496292 @default.
- W4387515607 hasRelatedWork W2149641002 @default.
- W4387515607 hasRelatedWork W2230364071 @default.
- W4387515607 hasRelatedWork W2804323293 @default.
- W4387515607 hasRelatedWork W2946983779 @default.
- W4387515607 hasRelatedWork W3080740709 @default.
- W4387515607 hasRelatedWork W3094570455 @default.
- W4387515607 hasRelatedWork W4309232485 @default.
- W4387515607 hasRelatedWork W4386122889 @default.
- W4387515607 isParatext "false" @default.
- W4387515607 isRetracted "false" @default.
- W4387515607 workType "article" @default.