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- W4387515945 abstract "The membrane potential (MP) controls cell homeostasis by directing molecule transport and gene expression. How the MP is set upon epithelial differentiation is unknown. Since tissue architecture also controls homeostasis, we investigated the relationship between basoapical polarity and resting MP in three-dimensional culture of the HMT-3522 breast cancer progression. A microelectrode technique to measure MP and input resistance reveals that the MP is raised by gap junction intercellular communication (GJIC) that directs tight-junction mediated apical polarity, and decreased by the Na+/K+/2Cl- (NKCC) cotransporter, present together with basal polarity. In the tumor counterpart, the MP is reduced. Cancer cells display diminished GJIC and do not respond to furosemide, implying loss of NKCC activity. Induced-differentiation of cancer cells into basally polarized multicellular structures restores widespread GJIC and NKCC response, but these structures display the lowest MP. The absence of apical polarity, necessary for cancer onset, in the non-neoplastic epithelium is also associated with the lowest MP under active Cl- transport. We propose that the loss of apical polarity in the breast epithelium destabilizes cellular homeostasis in part by lowering the MP." @default.
- W4387515945 created "2023-10-12" @default.
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- W4387515945 date "2023-10-11" @default.
- W4387515945 modified "2023-10-12" @default.
- W4387515945 title "The epithelial polarity axis controls the resting membrane potential and Cl− cotransport in breast glandular structures" @default.
- W4387515945 doi "https://doi.org/10.1242/jcs.260924" @default.
- W4387515945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37818620" @default.
- W4387515945 hasPublicationYear "2023" @default.
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