Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387516296> ?p ?o ?g. }
- W4387516296 abstract "In this study, we present the synthesis and incorporation of a metabolic isoleucine precursor compound for selective methylene labeling. The utility of this novel α-ketoacid isotopologue is shown by incorporation into the protein Brd4-BD1, which regulates gene expression by binding to acetylated histones. High quality single quantum 13C-1 H-HSQC were obtained, as well as triple quantum HTQC spectra, which are superior in terms of significantly increased 13C-T2 times. Additionally, large chemical shift perturbations upon ligand binding were observed. Our study thus proves the great sensitivity of this precursor as a reporter for side-chain dynamic studies and for investigations of CH-π interactions in protein-ligand complexes." @default.
- W4387516296 created "2023-10-12" @default.
- W4387516296 creator A5007258911 @default.
- W4387516296 creator A5018521358 @default.
- W4387516296 creator A5018907948 @default.
- W4387516296 creator A5022881950 @default.
- W4387516296 creator A5027297889 @default.
- W4387516296 creator A5031411522 @default.
- W4387516296 creator A5039677478 @default.
- W4387516296 creator A5042675870 @default.
- W4387516296 creator A5077702058 @default.
- W4387516296 creator A5082040633 @default.
- W4387516296 date "2023-10-11" @default.
- W4387516296 modified "2023-10-18" @default.
- W4387516296 title "Synthesis of a 13C-methylene-labeled isoleucine precursor as a useful tool for studying protein side-chain interactions and dynamics" @default.
- W4387516296 cites W1209134892 @default.
- W4387516296 cites W1972091733 @default.
- W4387516296 cites W1977920448 @default.
- W4387516296 cites W1978573751 @default.
- W4387516296 cites W1979993712 @default.
- W4387516296 cites W1984745692 @default.
- W4387516296 cites W1989045942 @default.
- W4387516296 cites W1999767478 @default.
- W4387516296 cites W2023168641 @default.
- W4387516296 cites W2028816469 @default.
- W4387516296 cites W2046244584 @default.
- W4387516296 cites W2061151008 @default.
- W4387516296 cites W2068227670 @default.
- W4387516296 cites W2074856155 @default.
- W4387516296 cites W2077407469 @default.
- W4387516296 cites W2077751452 @default.
- W4387516296 cites W2077799531 @default.
- W4387516296 cites W2085998427 @default.
- W4387516296 cites W2091864876 @default.
- W4387516296 cites W2098376669 @default.
- W4387516296 cites W2109939279 @default.
- W4387516296 cites W2132180320 @default.
- W4387516296 cites W2137125172 @default.
- W4387516296 cites W2153872371 @default.
- W4387516296 cites W2169707043 @default.
- W4387516296 cites W2169821755 @default.
- W4387516296 cites W2170968160 @default.
- W4387516296 cites W2313422370 @default.
- W4387516296 cites W2315844426 @default.
- W4387516296 cites W2529642283 @default.
- W4387516296 cites W2625345109 @default.
- W4387516296 cites W2751759701 @default.
- W4387516296 cites W3033145177 @default.
- W4387516296 cites W3043241433 @default.
- W4387516296 cites W384364580 @default.
- W4387516296 cites W4200489509 @default.
- W4387516296 cites W4312113717 @default.
- W4387516296 doi "https://doi.org/10.1007/s10858-023-00427-2" @default.
- W4387516296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37816933" @default.
- W4387516296 hasPublicationYear "2023" @default.
- W4387516296 type Work @default.
- W4387516296 citedByCount "0" @default.
- W4387516296 crossrefType "journal-article" @default.
- W4387516296 hasAuthorship W4387516296A5007258911 @default.
- W4387516296 hasAuthorship W4387516296A5018521358 @default.
- W4387516296 hasAuthorship W4387516296A5018907948 @default.
- W4387516296 hasAuthorship W4387516296A5022881950 @default.
- W4387516296 hasAuthorship W4387516296A5027297889 @default.
- W4387516296 hasAuthorship W4387516296A5031411522 @default.
- W4387516296 hasAuthorship W4387516296A5039677478 @default.
- W4387516296 hasAuthorship W4387516296A5042675870 @default.
- W4387516296 hasAuthorship W4387516296A5077702058 @default.
- W4387516296 hasAuthorship W4387516296A5082040633 @default.
- W4387516296 hasBestOaLocation W43875162961 @default.
- W4387516296 hasConcept C116569031 @default.
- W4387516296 hasConcept C12554922 @default.
- W4387516296 hasConcept C147597530 @default.
- W4387516296 hasConcept C170493617 @default.
- W4387516296 hasConcept C178790620 @default.
- W4387516296 hasConcept C185592680 @default.
- W4387516296 hasConcept C193125475 @default.
- W4387516296 hasConcept C204921945 @default.
- W4387516296 hasConcept C2775981520 @default.
- W4387516296 hasConcept C2776580952 @default.
- W4387516296 hasConcept C2777305461 @default.
- W4387516296 hasConcept C2777454769 @default.
- W4387516296 hasConcept C2991951333 @default.
- W4387516296 hasConcept C32909587 @default.
- W4387516296 hasConcept C515207424 @default.
- W4387516296 hasConcept C521977710 @default.
- W4387516296 hasConcept C55493867 @default.
- W4387516296 hasConcept C59593255 @default.
- W4387516296 hasConcept C66974803 @default.
- W4387516296 hasConcept C71240020 @default.
- W4387516296 hasConcept C86803240 @default.
- W4387516296 hasConceptScore W4387516296C116569031 @default.
- W4387516296 hasConceptScore W4387516296C12554922 @default.
- W4387516296 hasConceptScore W4387516296C147597530 @default.
- W4387516296 hasConceptScore W4387516296C170493617 @default.
- W4387516296 hasConceptScore W4387516296C178790620 @default.
- W4387516296 hasConceptScore W4387516296C185592680 @default.
- W4387516296 hasConceptScore W4387516296C193125475 @default.
- W4387516296 hasConceptScore W4387516296C204921945 @default.
- W4387516296 hasConceptScore W4387516296C2775981520 @default.
- W4387516296 hasConceptScore W4387516296C2776580952 @default.